Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks
Han B, Chen X, Talebizadeh Z, Xu H. Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks. BMC Systems Biology 2012, 6: s14. PMID: 23281790, PMCID: PMC3524021, DOI: 10.1186/1752-0509-6-s3-s14.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlzheimer DiseaseArtificial IntelligenceAutistic DisorderBayes TheoremComputational BiologyComputer SimulationDatabases, GeneticEpistasis, GeneticGenome-Wide Association StudyHumansMacular DegenerationMarkov ChainsModels, GeneticMonte Carlo MethodPolymorphism, Single NucleotideConceptsEpistatic interaction detectionBayesian network structure learning methodTwo-layer Bayesian networkBayesian network-based methodBayesian networkInteraction detectionMarkov chain Monte Carlo methodsStructure learning methodReal disease dataNetwork-based methodReal GWAS datasetMonte Carlo methodHigh-order epistatic interactionsMachine learningSearch spaceLearning methodsDisease datasetCarlo methodTarget nodeModel complexityStatistical methodsReal dataNew scoring functionComplex human diseasesDataset