Oncogenes and tumor suppressor genes: comparative genomics and network perspectives
Zhu K, Liu Q, Zhou Y, Tao C, Zhao Z, Sun J, Xu H. Oncogenes and tumor suppressor genes: comparative genomics and network perspectives. BMC Genomics 2015, 16: s8. PMID: 26099335, PMCID: PMC4474543, DOI: 10.1186/1471-2164-16-s7-s8.Peer-Reviewed Original ResearchConceptsTumor suppressor geneEssential genesTSG proteinsEssential proteinsHuman protein-protein interaction networkCancer drug target proteinsSuppressor geneWhole human interactomeProtein-protein interaction networkCancer developmentMutation frequencyDirect interactionDrug target identificationCancer drug targetSomatic mutationsDrug target proteinsDrug target genesComparative genomicsLow mutation frequencyCellular functionsHuman interactomeMutation patternsGenetic variationGene setsHigh mutation frequency