Oncogenes and tumor suppressor genes: comparative genomics and network perspectives
Zhu K, Liu Q, Zhou Y, Tao C, Zhao Z, Sun J, Xu H. Oncogenes and tumor suppressor genes: comparative genomics and network perspectives. BMC Genomics 2015, 16: s8. PMID: 26099335, PMCID: PMC4474543, DOI: 10.1186/1471-2164-16-s7-s8.Peer-Reviewed Original ResearchConceptsTumor suppressor geneEssential genesTSG proteinsEssential proteinsHuman protein-protein interaction networkCancer drug target proteinsSuppressor geneWhole human interactomeProtein-protein interaction networkCancer developmentMutation frequencyDirect interactionDrug target identificationCancer drug targetSomatic mutationsDrug target proteinsDrug target genesComparative genomicsLow mutation frequencyCellular functionsHuman interactomeMutation patternsGenetic variationGene setsHigh mutation frequencyA comparative study of disease genes and drug targets in the human protein interactome
Sun J, Zhu K, Zheng W, Xu H. A comparative study of disease genes and drug targets in the human protein interactome. BMC Bioinformatics 2015, 16: s1. PMID: 25861037, PMCID: PMC4402590, DOI: 10.1186/1471-2105-16-s5-s1.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesDisease genesDrug targetsHuman protein-coding genesHuman protein-protein interaction networkProtein-protein interaction networkProtein-coding genesHuman protein interactomeComplex diseasesNovel drug targetsProtein interactomeAnatomical Therapeutic Chemical (ATC) classificationInteraction networksDisease proteinAssociation studiesGenesDisease categoriesInteractomeProteinMajor disease categoriesDifferent disease categoriesFirst comprehensive comparisonTargetTreatment efficacyHigh betweenness