2018
Toward a normalized clinical drug knowledge base in China—applying the RxNorm model to Chinese clinical drugs
Wang L, Zhang Y, Jiang M, Wang J, Dong J, Liu Y, Tao C, Jiang G, Zhou Y, Xu H. Toward a normalized clinical drug knowledge base in China—applying the RxNorm model to Chinese clinical drugs. Journal Of The American Medical Informatics Association 2018, 25: 809-818. PMID: 29635469, PMCID: PMC7647010, DOI: 10.1093/jamia/ocy020.Peer-Reviewed Original ResearchConceptsChinese patent drugDrug knowledge basePatent drugsClinical drugsChemical drugsChinese drugsManual reviewChinese patent medicineElectronic health record systemsClinical dataChina's health insurance systemHealth record systemsDrug AdministrationHealth insurance systemDrug informationDrugsPatent medicineDrug namesRecord systemPharmacy system
2017
A systematic analysis of FDA-approved anticancer drugs
Sun J, Wei Q, Zhou Y, Wang J, Liu Q, Xu H. A systematic analysis of FDA-approved anticancer drugs. BMC Systems Biology 2017, 11: 87. PMID: 28984210, PMCID: PMC5629554, DOI: 10.1186/s12918-017-0464-7.Peer-Reviewed Original ResearchConceptsDrug-cancer associationsAnticancer drugsTarget-based drugsEfficient anticancer drugsTarget-based approachCancer typesNew anticancer drugsNovel anticancer drugsClinical trial studyPharmaceutical researchTrial studyMore cancer typesUS FoodDrug AdministrationCytotoxic drugsPatient treatmentPotential candidateDrug mechanismsDrugsDrug repurposingSystematic investigationAssociationDrug targetsTyrosine kinaseSystematic discovery
2012
Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs
Liu M, Wu Y, Chen Y, Sun J, Zhao Z, Chen X, Matheny M, Xu H. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs. Journal Of The American Medical Informatics Association 2012, 19: e28-e35. PMID: 22718037, PMCID: PMC3392844, DOI: 10.1136/amiajnl-2011-000699.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsPost-marketing phaseDrug reactionsSevere adverse drug reactionsImportant adverse drug reactionsWithdrawal of rofecoxibPotential adverse drug reactionsPost-marketing surveillanceADR predictionPatient morbidityClinical trialsMajor causeLarge-scale studiesDrugsMolecular pathwaysDrug developmentPhenotypic featuresSignificant improvementPhenotypic characteristicsEarly stagesNetwork‐Assisted Investigation of Antipsychotic Drugs and Their Targets
Sun J, Xu H, Zhao Z. Network‐Assisted Investigation of Antipsychotic Drugs and Their Targets. Chemistry & Biodiversity 2012, 9: 900-910. PMID: 22589091, DOI: 10.1002/cbdv.201100356.Peer-Reviewed Original ResearchConceptsAdverse drug interactionsAntipsychotic drugsDrug interactionsDrug actionAtypical antipsychotic drugsTreatment of schizophreniaSevere mental disordersMolecular mechanismsPsychiatric medicationsReceptor profileMental disordersAntipsychoticsDrug-gene networkDrugsMolecular actionsDifferent molecular mechanismsDrugBank database