Comparative analysis of pharmacovigilance methods in the detection of adverse drug reactions using electronic medical records
Liu M, Hinz E, Matheny M, Denny J, Schildcrout J, Miller R, Xu H. Comparative analysis of pharmacovigilance methods in the detection of adverse drug reactions using electronic medical records. Journal Of The American Medical Informatics Association 2012, 20: 420-426. PMID: 23161894, PMCID: PMC3628053, DOI: 10.1136/amiajnl-2012-001119.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsElectronic medical recordsProportional reporting ratioVanderbilt University Medical CenterSpontaneous reporting systemDrug-event pairsDrug reactionsMedical recordsMedication ordersAbnormal laboratory resultsDrug-exposed groupNew adverse drug reactionsUniversity Medical CenterSpecific drug administrationReference standardLaboratory resultsUnexposed groupGamma Poisson ShrinkerMedical CenterPatient harmDrug AdministrationPharmacovigilance measuresBayesian confidence propagation neural networkEarly detectionReporting ratioDetecting Adverse Drug Reactions using Inpatient Medication Orders and Laboratory Tests Data
Liu M, Matheny M, Wu Y, Hinz E, Denny J, Schildcrout J, Miller R, Xu H. Detecting Adverse Drug Reactions using Inpatient Medication Orders and Laboratory Tests Data. 2012, 1: 131-131. DOI: 10.1109/hisb.2012.56.Peer-Reviewed Original ResearchAdverse drug reactionsElectronic medical recordsSpontaneous reporting systemProportional reporting ratioDrug reactionsMedication ordersDrug ordersInpatient medication ordersAbnormal laboratory resultsTime of admissionDrug-exposed groupChi-square testLaboratory resultsGamma Poisson ShrinkerUnexposed groupMedical recordsOdds ratioMedication safetyPatient harmBayesian confidence propagation neural networkEarly detectionReporting ratioEMR dataDay zeroReporting system