2015
Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
Sun J, Zhao M, Jia P, Wang L, Wu Y, Iverson C, Zhou Y, Bowton E, Roden D, Denny J, Aldrich M, Xu H, Zhao Z. Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action. PLOS Computational Biology 2015, 11: e1004202. PMID: 26083494, PMCID: PMC4470683, DOI: 10.1371/journal.pcbi.1004202.Peer-Reviewed Original ResearchConceptsGWAS datasetsPathway networkDisease genesGenome-wide association study datasetDrug targetsSignal transduction networksSignal transduction cascadeMultiple signaling pathwaysDrug-induced gene expressionNovel drug targetsTransduction networksTransduction cascadeEnrichment analysisGene expressionCommon genesMolecular mechanismsSignaling pathwaysGenesNovel MycLiterature miningMolecular modePathwayMetformin actionDrug actionDisease pathogenesis
2012
Network‐Assisted Investigation of Antipsychotic Drugs and Their Targets
Sun J, Xu H, Zhao Z. Network‐Assisted Investigation of Antipsychotic Drugs and Their Targets. Chemistry & Biodiversity 2012, 9: 900-910. PMID: 22589091, DOI: 10.1002/cbdv.201100356.Peer-Reviewed Original ResearchConceptsAdverse drug interactionsAntipsychotic drugsDrug interactionsDrug actionAtypical antipsychotic drugsTreatment of schizophreniaSevere mental disordersMolecular mechanismsPsychiatric medicationsReceptor profileMental disordersAntipsychoticsDrug-gene networkDrugsMolecular actionsDifferent molecular mechanismsDrugBank database