2024
NLP Applications—Other Biomedical Texts
Roberts K, Xu H, Demner Fushman D. NLP Applications—Other Biomedical Texts. Cognitive Informatics In Biomedicine And Healthcare 2024, 429-444. DOI: 10.1007/978-3-031-55865-8_15.Peer-Reviewed Original ResearchRepurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature
Xiao Y, Hou Y, Zhou H, Diallo G, Fiszman M, Wolfson J, Zhou L, Kilicoglu H, Chen Y, Su C, Xu H, Mantyh W, Zhang R. Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature. Scientific Reports 2024, 14: 8693. PMID: 38622164, PMCID: PMC11018822, DOI: 10.1038/s41598-024-58604-8.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseManual therapy techniquesR-GCNKnowledge graphAD preventionNon-pharmacological interventionsBiomedical literatureGraph convolutional network modelKG embedding modelsTest setLink prediction modelIntegrated healthConvolutional network modelImprove cognitive functionHighest scoring candidatesDomain expertsEmbedding modelNon-pharmaceutical interventionsReal-world data analysisGround truthPrevent ADCognitive functionTherapy techniquesNetwork modelDiscovery patternsEnsemble pretrained language models to extract biomedical knowledge from literature
Li Z, Wei Q, Huang L, Li J, Hu Y, Chuang Y, He J, Das A, Keloth V, Yang Y, Diala C, Roberts K, Tao C, Jiang X, Zheng W, Xu H. Ensemble pretrained language models to extract biomedical knowledge from literature. Journal Of The American Medical Informatics Association 2024, 31: 1904-1911. PMID: 38520725, PMCID: PMC11339500, DOI: 10.1093/jamia/ocae061.Peer-Reviewed Original ResearchNatural language processingNatural language processing systemsLanguage modelExpansion of biomedical literatureZero-shot settingManually annotated corpusKnowledge graph developmentTask-specific modelsDomain-specific modelsZero-ShotEntity recognitionBillion parametersEnsemble learningLocation informationKnowledge basesBiomedical entitiesLanguage processingFree textGraph developmentBiomedical conceptsAutomated techniqueBiomedical literatureDetection methodPredictive performanceBiomedical knowledge
2023
Repurposing Drugs for Alzheimer's Diseases through Link Prediction on Biomedical Literature
Xiao Y, Hou Y, Zhou H, Diallo G, Fiszman M, Wolfson J, Kilicoglu H, Chen Y, Xu H, Mantyh W, Zhang R. Repurposing Drugs for Alzheimer's Diseases through Link Prediction on Biomedical Literature. 2023, 00: 750-752. DOI: 10.1109/ichi57859.2023.00137.Peer-Reviewed Original ResearchAlzheimer's diseaseKnowledge graphKnowledge graph embedding modelsGraph convolutional network modelComputational drug repurposingGraph embedding modelsTest setConvolutional network modelBiomedical knowledge graphComprehensive knowledge graphDietary supplementsR-GCNEmbedding modelDrug repurposingLink predictionPrediction taskSemantic triplesNetwork modelAlzheimerBiomedical literatureNovel drugsRepurposed drugsGraph
2022
Discovering novel drug-supplement interactions using SuppKG generated from the biomedical literature
Schutte D, Vasilakes J, Bompelli A, Zhou Y, Fiszman M, Xu H, Kilicoglu H, Bishop J, Adam T, Zhang R. Discovering novel drug-supplement interactions using SuppKG generated from the biomedical literature. Journal Of Biomedical Informatics 2022, 131: 104120. PMID: 35709900, PMCID: PMC9335448, DOI: 10.1016/j.jbi.2022.104120.Peer-Reviewed Original ResearchConceptsUnified Medical Language SystemComprehensive knowledge graphDomain terminologyKnowledge graphSemantic relationsNatural language processing technologyLanguage processing technologyNLP toolsDownstream tasksF1 scoreSemantic relationshipsDiscovery patternsPubMed abstractsLimited coverageBiomedical literatureProcessing technologyLanguage systemSemRepDietary supplement informationManual reviewNovel methodologyGraphNodesDomainTask
2020
Relation Extraction from Clinical Narratives Using Pre-trained Language Models.
Wei Q, Ji Z, Si Y, Du J, Wang J, Tiryaki F, Wu S, Tao C, Roberts K, Xu H. Relation Extraction from Clinical Narratives Using Pre-trained Language Models. AMIA Annual Symposium Proceedings 2020, 2019: 1236-1245. PMID: 32308921, PMCID: PMC7153059.Peer-Reviewed Original ResearchConceptsPre-trained language modelsNatural language processingLanguage modelRE tasksNLP tasksClinical narrativesRecent deep learning methodsDeep learning methodsClinical NLP tasksRelation extraction taskTraditional word embeddingsTraditional machineExtraction taskArt performanceRelation extractionBERT modelLanguage processingLearning methodsWord embeddingsShared TaskPrevious stateBiomedical literatureDifferent implementationsTaskOpen domain
2019
Recognizing software names in biomedical literature using machine learning
Wei Q, Zhang Y, Amith M, Lin R, Lapeyrolerie J, Tao C, Xu H. Recognizing software names in biomedical literature using machine learning. Health Informatics Journal 2019, 26: 21-33. PMID: 31566474, PMCID: PMC7334865, DOI: 10.1177/1460458219869490.Peer-Reviewed Original ResearchConceptsSoftware namesF-measureNatural language processing methodsBiomedical literatureWord representation featuresLanguage processing methodsEntity recognition systemSoftware catalogSoftware repositoriesFeature engineeringBiomedical softwareRecognition systemSoftware toolsBiomedical domainRepresentation featuresMEDLINE abstractsWord embeddingsKnowledge featuresManual curationSoftwareMachineProcessing methodsBest systemRepositorySystem
2018
Adapting Word Embeddings from Multiple Domains to Symptom Recognition from Psychiatric Notes.
Zhang Y, Li H, Wang J, Cohen T, Roberts K, Xu H. Adapting Word Embeddings from Multiple Domains to Symptom Recognition from Psychiatric Notes. AMIA Joint Summits On Translational Science Proceedings 2018, 2017: 281-289. PMID: 29888086, PMCID: PMC5961810.Peer-Reviewed Original ResearchWord embeddingsClinical textTarget domainSource domainNatural language processing techniquesLanguage processing techniquesMultiple word embeddingsBaseline methodsBiomedical literatureFirst workProcessing techniquesEmbeddingPsychiatric notesMultiple domainsExperimental resultsDifferent weightsSuch informationImportant topicRecognitionDifferent approachesWikipediaInformationPersonalizationDomainText
2017
Knowledge-Based Approach for Named Entity Recognition in Biomedical Literature: A Use Case in Biomedical Software Identification
Amith M, Zhang Y, Xu H, Tao C. Knowledge-Based Approach for Named Entity Recognition in Biomedical Literature: A Use Case in Biomedical Software Identification. Lecture Notes In Computer Science 2017, 10351: 386-395. DOI: 10.1007/978-3-319-60045-1_40.Peer-Reviewed Original ResearchEntity recognitionNatural language processingContextual semantic informationNamed Entity RecognitionEntity recognition methodFeatures of ontologyMachine learning approachesKnowledge-based approachSoftware entitiesSoftware namesInformation extractionUse casesBiomedical softwareSemantic informationSoftware identificationLanguage processingRecognition methodLearning approachBiomedical literatureRecognitionOntologyEntitiesSoftwareResearch abstractsTask
2016
Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature
Zhang Y, Wu H, Xu J, Wang J, Soysal E, Li L, Xu H. Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature. BMC Systems Biology 2016, 10: 67. PMID: 27585838, PMCID: PMC5009562, DOI: 10.1186/s12918-016-0311-2.Peer-Reviewed Original ResearchConceptsPaths graph kernelGraph kernelsSemantic classesSemantic informationBiomedical literatureShallow semantic representationsText mining techniquesBest F-scoreAutomatic DDI extractionProblem of sparsenessDependency structureSemantic graphDDI detectionKnowledge basesDDI corpusF-scoreDDI extractionSemantic representationNovel approachExperimental resultsKernelHigh precisionInformationSparsenessGraphCD-REST: a system for extracting chemical-induced disease relation in literature
Xu J, Wu Y, Zhang Y, Wang J, Lee H, Xu H. CD-REST: a system for extracting chemical-induced disease relation in literature. Database 2016, 2016: baw036. PMID: 27016700, PMCID: PMC4808251, DOI: 10.1093/database/baw036.Peer-Reviewed Original ResearchConceptsChemical-induced disease relationsWeb servicesBiomedical literatureEntity recognitionMachine learning-based approachLearning-based approachHTTP POST requestRelation extraction systemVector space modelConditional Random FieldsSupport vector machineRelation extraction moduleVast biomedical literatureDisease relation extractionChemical-induced disease relation extractionExtraction moduleDisease relationsAutomatic extractionEnd systemPOST requestRelation extractionNormalization moduleVector machineBioCreative VDemonstration system
2015
Domain adaptation for semantic role labeling of clinical text
Zhang Y, Tang B, Jiang M, Wang J, Xu H. Domain adaptation for semantic role labeling of clinical text. Journal Of The American Medical Informatics Association 2015, 22: 967-979. PMID: 26063745, PMCID: PMC4986662, DOI: 10.1093/jamia/ocu048.Peer-Reviewed Original ResearchUsing Ontology Fingerprints to disambiguate gene name entities in the biomedical literature
Chen G, Zhao J, Cohen T, Tao C, Sun J, Xu H, Bernstam E, Lawson A, Zeng J, Johnson A, Holla V, Bailey A, Lara-Guerra H, Litzenburger B, Meric-Bernstam F, Zheng W. Using Ontology Fingerprints to disambiguate gene name entities in the biomedical literature. Database 2015, 2015: bav034. PMID: 25858285, PMCID: PMC4390608, DOI: 10.1093/database/bav034.Peer-Reviewed Original Research
2014
Identifying plausible adverse drug reactions using knowledge extracted from the literature
Shang N, Xu H, Rindflesch T, Cohen T. Identifying plausible adverse drug reactions using knowledge extracted from the literature. Journal Of Biomedical Informatics 2014, 52: 293-310. PMID: 25046831, PMCID: PMC4261011, DOI: 10.1016/j.jbi.2014.07.011.Peer-Reviewed Original ResearchConceptsPredication-based Semantic IndexingReflective Random IndexingLBD methodsNatural language processing toolsBiomedical literatureDrug-adverse event associationsLanguage processing toolsSemantic indexingElectronic health recordsRandom IndexingHuman reviewVast repositoryDiscovery methodsVolume of knowledgeProcessing toolsEvaluation setHealth recordsData sourcesEvent associationsIndexingDrug-effect relationshipsRepositoryLarge volumesADR associationsReasoning pathways
2007
A study of abbreviations in clinical notes.
Xu H, Stetson P, Friedman C. A study of abbreviations in clinical notes. AMIA Annual Symposium Proceedings 2007, 2007: 821-5. PMID: 18693951, PMCID: PMC2655910.Peer-Reviewed Original ResearchConceptsUnified Medical Language SystemNatural language processing systemsLanguage processing systemNarrative clinical notesDetection methodClinical notesDifferent knowledge sourcesSense inventoryDomain expertsNLP systemsCorrect sensesDecision supportText corporaKnowledge sourcesError detectionProcessing systemBiomedical literatureStudy of abbreviationsLanguage systemPatient informationAmbiguity rateBetter detection methodsDatabaseAnnotationAbbreviations