2017
Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports
Cai R, Liu M, Hu Y, Melton B, Matheny M, Xu H, Duan L, Waitman L. Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports. Artificial Intelligence In Medicine 2017, 76: 7-15. PMID: 28363289, PMCID: PMC6438384, DOI: 10.1016/j.artmed.2017.01.004.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsTraditional association rule mining methodsAssociation rule mining methodAssociation rule discoveryAssociation rule miningRule mining methodAdverse Event Reporting SystemAdverse drug-drug interactionsAdverse event reportsAdverse eventsData-driven discoveryHigher-order associationsRule miningRule discoveryDrug safety surveillanceMining methodsBayesian networkDrug combinationsChallenging taskCausal associationDrug Administration Adverse Event Reporting SystemDDI identificationAdverse drug reactionsCombination of drugsEvent Reporting System
2012
Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks
Han B, Chen X, Talebizadeh Z, Xu H. Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks. BMC Systems Biology 2012, 6: s14. PMID: 23281790, PMCID: PMC3524021, DOI: 10.1186/1752-0509-6-s3-s14.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlzheimer DiseaseArtificial IntelligenceAutistic DisorderBayes TheoremComputational BiologyComputer SimulationDatabases, GeneticEpistasis, GeneticGenome-Wide Association StudyHumansMacular DegenerationMarkov ChainsModels, GeneticMonte Carlo MethodPolymorphism, Single NucleotideConceptsEpistatic interaction detectionBayesian network structure learning methodTwo-layer Bayesian networkBayesian network-based methodBayesian networkInteraction detectionMarkov chain Monte Carlo methodsStructure learning methodReal disease dataNetwork-based methodReal GWAS datasetMonte Carlo methodHigh-order epistatic interactionsMachine learningSearch spaceLearning methodsDisease datasetCarlo methodTarget nodeModel complexityStatistical methodsReal dataNew scoring functionComplex human diseasesDataset