Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies
Song S, Jiang W, Hou L, Zhao H. Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies. PLOS Computational Biology 2020, 16: e1007565. PMID: 32045423, PMCID: PMC7039528, DOI: 10.1371/journal.pcbi.1007565.Peer-Reviewed Original ResearchConceptsEffect size distributionClass of methodsReal data applicationOnly summary statisticsTheoretical resultsSummary statisticsExtensive simulation resultsLD informationSimulation resultsData applicationsFirst methodImportant problemOptimal propertiesGenetic risk predictionAccurate predictionPrediction accuracyStandard PRSStatisticsPrediction method