2021
VPS13D bridges the ER to mitochondria and peroxisomes via Miro
Guillén-Samander A, Leonzino M, Hanna MG, Tang N, Shen H, De Camilli P. VPS13D bridges the ER to mitochondria and peroxisomes via Miro. Journal Of Cell Biology 2021, 220: e202010004. PMID: 33891013, PMCID: PMC8077184, DOI: 10.1083/jcb.202010004.Peer-Reviewed Original ResearchConceptsLipid transport proteinsHigher eukaryotesER-mitochondriaSecretory pathwayAccessory factorsMitochondrial dynamicsDisease pathogenesisTransport proteinsParkin substratesLipid transferSplice variantsParkinson's disease pathogenesisVps13Lipid supplyMitochondriaMiroVPS13DERMESYeastMost lipidsTransport domainEukaryotesGem1MetazoansER
2012
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 4419-4424. PMID: 22371560, PMCID: PMC3311323, DOI: 10.1073/pnas.1200164109.Peer-Reviewed Original ResearchConceptsEGFR endocytosisPlasma membraneDynamin-mediated endocytosisEndocytosis of EGFRRole of endocytosisLow-affinity EGFRsEGF receptor activationCell surface receptorsMAPK responseMAPK stimulationEGFR degradationAkt stimulationCell signalingDynaminEGFR activationEGFR autophosphorylationAkt activationEndocytosisCell surfaceSurface receptorsMouse fibroblastsAkt responseReceptor activationHigh EGF concentrationsActivation