2024
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2021
Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer
Slovak RJ, Park HJ, Kamp WM, Ludwig JM, Kang I, Kim HS. Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Scientific Reports 2021, 11: 6956. PMID: 33772035, PMCID: PMC7997991, DOI: 10.1038/s41598-021-85810-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCD4-Positive T-LymphocytesCell Line, TumorCell ProliferationColorectal NeoplasmsCTLA-4 AntigenFemaleHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred BALB CMicrosatellite RepeatsProgrammed Cell Death 1 ReceptorSpleenT-Lymphocytes, CytotoxicConceptsDual checkpoint inhibitionPD-1 inhibitionColorectal cancerCheckpoint inhibitionPD-1Checkpoint inhibitorsT cellsImmune responseRobust anti-tumor immune responseAnti-PD-1 groupAnti-PD-1 antibodyAnti-tumor immune responseMicrosatellite stable colorectal cancerDual PD-1Majority of patientsDeficient mismatch repairStable colorectal cancerCTLA-4 inhibitionTumor growth rateHigh microsatellite instabilityPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsTumoral infiltrationDual therapy
2020
IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis
Shin MS, Kim D, Yim K, Park HJ, You S, Dong X, Koumpouras F, Shaw AC, Fan R, Krishnaswamy S, Kang I. IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis. Cellular Immunology 2020, 355: 104155. PMID: 32619811, PMCID: PMC7415611, DOI: 10.1016/j.cellimm.2020.104155.Peer-Reviewed Original ResearchConceptsSingle-cell RNA-seqHuman effector memory CD8Effector memory CD8T cellsIL-7RαMemory CD8Gene regulationTranscription factorsRNA-seqPossible biological significanceDownstream eventsEM CD8Expression patternsExpressional relationshipDifferential expressionCytokine receptorsComprehensive landscapeHigh-dimensional cytometryBiological significanceIL-7 receptor alphaKey moleculesIL-7 receptor alpha chainReceptor alpha chainBiological implicationsHeterogeneous cell subsets
2019
Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profilesEstrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Kim D, Park H, Park H, Lee J, Ko C, Gye M, Choi J. Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity. Experimental & Molecular Medicine 2019, 51: 1-9. PMID: 30988419, PMCID: PMC6465332, DOI: 10.1038/s12276-019-0237-z.Peer-Reviewed Original ResearchConceptsSheep red blood cellsKO miceT cellsTfh cellsTfh responsesAutoantibody productionFollicular helper T cell responsesHigh-affinity antigen-specific antibodiesCell responsesFollicular helper T cellsHelper T cell responsesERα KO miceTfh cell responsesMesenteric lymph nodesT cell responsesHelper T cellsGerminal center responseERα knockout miceWild-type miceAntigen-specific antibodiesYears of ageEstrogen receptor alphaEstrogen receptor αIsotype class switchingTreg cellsDissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry
Shin MS, Yim K, Moon K, Park HJ, Mohanty S, Kim JW, Montgomery RR, Shaw AC, Krishnaswamy S, Kang I. Dissecting alterations in human CD8+ T cells with aging by high-dimensional single cell mass cytometry. Clinical Immunology 2019, 200: 24-30. PMID: 30659916, PMCID: PMC6443094, DOI: 10.1016/j.clim.2019.01.005.Peer-Reviewed Original Research
2017
Sex-specific regulation of immune responses by PPARs
Park H, Choi J. Sex-specific regulation of immune responses by PPARs. Experimental & Molecular Medicine 2017, 49: e364-e364. PMID: 28775365, PMCID: PMC5579504, DOI: 10.1038/emm.2017.102.Peer-Reviewed Original ResearchConceptsImmune responseT cellsEffector T cell responsesPeroxisome proliferator-activated receptor ligandsSex-specific immune responsesExperimental autoimmune encephalomyelitisEffector T cellsT cell responsesRole of PPART cell activationHost diseaseAutoimmune encephalomyelitisAutoimmune diseasesSex hormonesForeign antigensSex-specific differencesKnockout miceMetabolic diseasesImmune systemPPARReceptor ligandsInhibitory functionDiseaseSex-specific regulationSex differences
2016
Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation. International Journal Of Molecular Sciences 2016, 17: 1347. PMID: 27548145, PMCID: PMC5000743, DOI: 10.3390/ijms17081347.Peer-Reviewed Original ResearchConceptsEffector T cell differentiationT cellsT cell differentiationAdaptive immunityFemale T cellsMale T cellsPeroxisome proliferator-activated receptor gammaIL-17 productionDifferentiation of Th1PPARγ agonist pioglitazoneProliferator-activated receptor gammaNaïve T cellsSplenic T cellsMouse splenic T cellsImportant immune regulatorPioglitazone treatmentTfh responsesTh17 cellsAgonist pioglitazoneTreg functionAutoimmune diseasesEstrogen exposureImmune regulatorsCell differentiationTh1Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen. Scientific Reports 2016, 6: 28495. PMID: 27335315, PMCID: PMC4917844, DOI: 10.1038/srep28495.Peer-Reviewed Original ResearchConceptsFollicular helper T cell responsesHelper T cell responsesT cell responsesCell responsesTfh cellsT cellsGC responseMale T cellsPeroxisome proliferator-activated receptor gammaTfh cell responsesEffector T cellsPPARγ agonist pioglitazoneProliferator-activated receptor gammaT cell regulationWild-type miceRole of PPARγGerminal center B cellsT cell activationGender-specific differencesTfh responsesAgonist pioglitazoneAutoimmune diseasesMenstrual cycleFemale miceMale mice
2015
Piceatannol inhibits effector T cell functions by suppressing TcR signaling
Kim D, Lee Y, Park H, Lee J, Kim H, Hwang J, Choi J. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. International Immunopharmacology 2015, 25: 285-292. PMID: 25676533, DOI: 10.1016/j.intimp.2015.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleInterleukin-2 Receptor alpha SubunitLectins, C-TypeMice, Inbred C57BLMitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsReceptors, Antigen, T-CellSpleenStilbenesConceptsEffector T cell functionT cell functionT cellsPiceatannol treatmentT cell activation markers CD25Naïve CD4 T cellsRole of piceatannolCD4 T cellsActivation markers CD25Cell functionAdaptive immune responsesSplenic T cellsMetabolite of resveratrolMurine splenic T cellsInhibition of TCRActivated T cellsAnti-tumorigenesis activityT cell activationIL-17Th17 cellsCytokines IFNγC57BL/6 miceCytokine productionIL-2Immune response
2010
TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)
Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, Song S. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochemical And Biophysical Research Communications 2010, 396: 721-725. PMID: 20450885, DOI: 10.1016/j.bbrc.2010.04.169.Peer-Reviewed Original ResearchConceptsInterleukin-1 receptor-associated kinase 1TNF-alpha productionKorean mistletoe lectinTNF-alphaTLR4 moleculesMouse macrophagesReceptor-associated kinase 1Mucosal immune cellsTNF-alpha secretionMistletoe lectinMouse peritoneal macrophagesImmune cellsMacrophage activationTLR4Immunomodulatory activityPeritoneal macrophagesMacrophagesCancer cellsUnderlying mechanismKinase 1ActivationDownstream eventsCellsCytokinesAdjuvant