2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Nature Communications 2018, 9: 503. PMID: 29403003, PMCID: PMC5799380, DOI: 10.1038/s41467-017-02731-6.Peer-Reviewed Original ResearchConceptsT cellsLung metastasesTh1 cellsCHI3L1 expressionFunction of CHI3L1Type 2 inflammationAnti-tumor immunityMelanoma lung metastasisActivated T cellsElicit Th1CTL responsesEnhanced Th1Th2 cellsTherapeutic targetClinical implicationsCytotoxic responseTh1MetastasisTCR stimulationCHI3L1Peptide-siRNA complexLungCellsNegative regulatorImmunity genes
2015
Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633)
Kim D, Park H, Lee J, Kang M, Lee C, Elias J, Choi J. Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633). The Journal Of Immunology 2015, 194: 201.9-201.9. DOI: 10.4049/jimmunol.194.supp.201.9.Peer-Reviewed Original ResearchT cell immunityBRP-39Th1 cellsT cellsTCR stimuliUp-regulate T-betExpression of PTPN2Naive CD4 T cellsIncreased production of IL-2Production of IL-2CD4 T cellsNaive T cellsT cell activationEnzyme sitesChitinase activityParasite life cycleAnti-parasite immune responsesSignaling pathwayRegulatory roleChitinaseTh2 cellsInnate immunityT-betTh1 differentiationIFN-g