2016
BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis
Lim S, Kim W, Kim Y, Lee S, Koo J, Lee J, Kim H, Park H, Kim D, Lee H, Yoon H, Kim J, Shin J, Kim L, Doh J, Kim H, Bothwell A, Lee S, Suh M, Choi J. BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis. The Journal Of Immunology 2016, 196: 139.7-139.7. DOI: 10.4049/jimmunol.196.supp.139.7.Peer-Reviewed Original ResearchCentral nervous systemBlood-brain barrierExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsAbstract Multiple sclerosisCNS inflammatory diseasesInfiltrated T cellsEffector T cellsHelper 17 cellsSevere autoimmune diseaseT helper 1Activated T cellsMOG35-55Autoimmune encephalomyelitisTh17 responsesHelper 1Autoimmune diseasesCytokine productionSevere inflammationAntigen-4Model mice
2015
dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
Lim S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Yoon H, Kim DH, Park HJ, Kim HM, Lee HG, Yun Kim J, Lee JU, Hun Shin J, Kyun Kim L, Doh J, Kim H, Lee SK, Bothwell AL, Suh M, Choi JM. dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nature Communications 2015, 6: 8244. PMID: 26372309, PMCID: PMC4579786, DOI: 10.1038/ncomms9244.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsAutoimmune encephalomyelitisCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsCNS inflammatory diseasesTherapeutic mouse modelsEffector T cellsHelper 17 cellsT helper 1Blood-brain barrierCentral nervous systemHuman T cellsHelper 1Antigen-4Inflammatory diseasesMouse modelNervous systemCurrent drugsResident cellsBrain tissueEffective agentCell-permeable peptide