2020
Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes
Shen LL, Ahluwalia A, Sun M, Young BK, Nardini H, Del Priore LV. Long-term natural history of visual acuity in eyes with choroideremia: a systematic review and meta-analysis of data from 1004 individual eyes. British Journal Of Ophthalmology 2020, 105: 271-278. PMID: 32471821, PMCID: PMC7704705, DOI: 10.1136/bjophthalmol-2020-316028.Peer-Reviewed Original ResearchConceptsBest-corrected visual acuityLong-term natural historyHorizontal translation factorPrimary endpointVisual acuityNatural historyCommon primary endpointBCVA declineYounger patientsUntreated eyesFuture trialsTreatment trialsAge 39Transition ageSystematic reviewFunction of ageIndividual eyesChoroideremiaAgeEndpointSole endpointEyesPatientsAcuityDisease biomarkersProgression of Unifocal versus Multifocal Geographic Atrophy in Age-Related Macular Degeneration A Systematic Review and Meta-analysis
Shen LL, Sun M, Grossetta Nardini HK, Del Priore LV. Progression of Unifocal versus Multifocal Geographic Atrophy in Age-Related Macular Degeneration A Systematic Review and Meta-analysis. Ophthalmology Retina 2020, 4: 899-910. PMID: 32423772, PMCID: PMC7483721, DOI: 10.1016/j.oret.2020.03.020.Peer-Reviewed Original ResearchConceptsMultifocal geographic atrophyGeographic atrophyMacular Degeneration A Systematic ReviewNonexudative age-related macular degenerationAge-related macular degenerationHorizontal translation factorPrognosis Studies toolSignificant prognostic factorsA Systematic ReviewColor fundus photographyGA growth rateMultifocal groupPrognostic factorsFundus autofluorescenceGA patientsFundus photographyEgger's testMacular degenerationStudy qualityFunnel plotSystematic reviewMeta-AnalysisPublication biasGA lesionsLesion perimeterLong-term Natural History of Atrophy in Eyes with Choroideremia—A Systematic Review and Meta-analysis of Individual-Level Data
Shen LL, Ahluwalia A, Sun M, Young BK, Grossetta Nardini HK, Del Priore LV. Long-term Natural History of Atrophy in Eyes with Choroideremia—A Systematic Review and Meta-analysis of Individual-Level Data. Ophthalmology Retina 2020, 4: 840-852. PMID: 32362554, PMCID: PMC7415675, DOI: 10.1016/j.oret.2020.03.003.Peer-Reviewed Original ResearchConceptsResidual retinal pigment epitheliumLong-term natural historyHorizontal translation factorFundus autofluorescenceRPE areaNatural historyUntreated eyesSystematic reviewPrognosis Studies toolRisk of biasRetinal pigment epitheliumLog-transformed areaAnatomic endpointsPatient ageRPE changesTreatment trialsDisease progressionAnatomic measuresPigment epitheliumMeta-AnalysisLiterature databasesIndividual eyesCross-sectional dataChoroideremiaAtrophyUpdating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
Wallach JD, Wang K, Zhang AD, Cheng D, Grossetta Nardini HK, Lin H, Bracken MB, Desai M, Krumholz HM, Ross JS. Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses. The BMJ 2020, 368: l7078. PMID: 32024657, PMCID: PMC7190063, DOI: 10.1136/bmj.l7078.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataCardiovascular related deathsCardiovascular riskMyocardial infarctionRelated deathsSummary-level dataHeart failureOdds ratioSystematic reviewIncreased cardiovascular riskMore myocardial infarctionsHeart failure eventsCochrane Central RegistryAcute myocardial infarctionMyocardial infarction eventsPatient-level dataRandom-effects modelWeb of ScienceAnalysis of trialsEligible trialsComposite outcomeAdverse eventsContinuity correctionControlled TrialsRosiglitazone treatment
2019
Natural History of Autosomal Recessive Stargardt Disease in Untreated Eyes A Systematic Review and Meta-analysis of Study- and Individual-Level Data
Shen LL, Sun M, Grossetta Nardini HK, Del Priore LV. Natural History of Autosomal Recessive Stargardt Disease in Untreated Eyes A Systematic Review and Meta-analysis of Study- and Individual-Level Data. Ophthalmology 2019, 126: 1288-1296. PMID: 31227323, DOI: 10.1016/j.ophtha.2019.05.015.Peer-Reviewed Original ResearchConceptsBaseline lesion sizeHorizontal translation factorAutosomal recessive Stargardt diseaseRecessive Stargardt diseaseLog-transformed areaLesion sizeUntreated eyesAtrophic lesionsStargardt diseaseSystematic reviewNatural historyOnset of symptomsNewcastle-Ottawa ScaleRisk of biasReliable outcome measuresIndividual-level dataAtrophy progressionFundus autofluorescenceInclusion criteriaOutcome measuresMeta-AnalysisLesion onsetProgression patternsLiterature databasesLesions
2018
Fellow Eye Status Is a Biomarker for the Progression Rate of Geographic Atrophy A Systematic Review and Meta-analysis
Shen LL, Liu F, Grossetta Nardini H, Del Priore LV. Fellow Eye Status Is a Biomarker for the Progression Rate of Geographic Atrophy A Systematic Review and Meta-analysis. Ophthalmology Retina 2018, 3: 305-315. PMID: 31014681, DOI: 10.1016/j.oret.2018.11.013.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationFellow eye statusFellow eyesChoroidal neovascularizationGeographic atrophyProgression rateEye statusPrimary eyesSystematic reviewAdvanced age-related macular degenerationGA enlargement rateHorizontal translation factorA Systematic ReviewGA progression ratesNewcastle-Ottawa ScalePrior clinical studiesDifferent entry timesGA patientsCochrane LibraryClinical trialsClinical studiesEgger's testMacular degenerationStudy qualityBegg's test
2017
Systematic review of community-engaged research in ophthalmology
Nwanyanwu KH, Nardini H, Shaughness G, Nunez-Smith M, Newman-Casey PA. Systematic review of community-engaged research in ophthalmology. Expert Review Of Ophthalmology 2017, 12: 233-241. PMID: 29333193, PMCID: PMC5759339, DOI: 10.1080/17469899.2017.1311787.Peer-Reviewed Original ResearchCommunity-engaged researchOvid EmbaseCochrane LibraryCommunity-based participatory researchMedical Subject HeadingsOvid MEDLINEEye diseaseNLM PubMedHealth outcomesSystematic reviewHealth disparitiesVision disordersComprehensive searchOphthalmic researchRelevant studiesOphthalmologyAdditional referencesFull textParticipatory researchExpert consultationOutcomesSubject headingsUnique referencesField of medicineCommunity engagement
2016
Utility of MRI for cervical spine clearance after blunt traumatic injury: a meta-analysis
Malhotra A, Wu X, Kalra VB, Nardini HK, Liu R, Abbed KM, Forman HP. Utility of MRI for cervical spine clearance after blunt traumatic injury: a meta-analysis. European Radiology 2016, 27: 1148-1160. PMID: 27334017, DOI: 10.1007/s00330-016-4426-z.Peer-Reviewed Original ResearchConceptsPositive finding rateUnstable injuriesUtility of MRIAlert patientsPooled incidenceCervical spine trauma patientsCervical spine clearanceBlunt traumatic injurySpine trauma patientsMajor medical databasesFurther studiesCS clearanceSpine clearanceTrauma patientsAwake patientsNegative CTTraumatic injuryPatientsUnique citationsSystematic reviewInjuryPositive findingsIncidenceMRIHigh false positive rate