A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories
De Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T, Spencer DD. A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories. Epilepsia 2003, 44: 677-687. PMID: 12752467, DOI: 10.1046/j.1528-1157.2003.32701.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultApoptosisCell CountCulture TechniquesDentate GyrusDynorphinsElectroencephalographyEpilepsy, Temporal LobeEvoked PotentialsFemaleFollow-Up StudiesHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleNeuronsNeuropeptide YReference ValuesRetrospective StudiesSclerosisSomatostatinSubstance PTreatment OutcomeConceptsIntractable temporal lobe epilepsyTemporal lobe epilepsyDentate granule cellsLobe epilepsySurgical outcomesNeuronal lossNeuronal densityGranule cellsDentate gyrusNonsclerotic hippocampiRetrospective analysisHippocampal subfieldsHuman temporal lobe epilepsyBasis of pathophysiologyEvidence of sclerosisSignificant neuronal lossExtensive neuronal lossSharp electrode recordingsPatient subcategoriesSignificant hyperexcitabilityAutopsy controlsHippocampal pathologyNeuropeptide YImmunohistochemical characteristicsSubstance P