2018
2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain
Gruenbaum S, Dhaher R, Behar K, Zaveri H, Erfe M, Eid T. 2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain. Journal Of Clinical And Translational Science 2018, 2: 1-1. PMCID: PMC6808188, DOI: 10.1017/cts.2018.37.Peer-Reviewed Original ResearchIpsilateral hippocampusDentate gyrusAstroglial glutamine synthetaseMicrodialysis guide cannulaBlood-brain barrierImmune system dysfunctionRight dentate gyrusBilateral dentate gyrusL-type amino acid transporterBrief isoflurane anesthesiaArtificial extracellular fluidSignificant increaseGlutamine concentrationImportant therapeutic targetBilateral microdialysis probesAmino acid influxMethionine sulfoximineContralateral hippocampusLiver diseaseBrain ammoniaSynaptic glutamateBrain barrierSystem dysfunctionGuide cannulaIsoflurane anesthesia
2015
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy
Gruenbaum SE, Wang H, Zaveri HP, Tang AB, Lee TS, Eid T, Dhaher R. Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy & Behavior 2015, 51: 96-103. PMID: 26262937, PMCID: PMC4663049, DOI: 10.1016/j.yebeh.2015.07.015.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnhedoniaAnimalsBrainCentral Amygdaloid NucleusComorbidityDepressive DisorderDisease Models, AnimalElectroencephalographyEnzyme InhibitorsEpilepsy, Temporal LobeGlutamate-Ammonia LigaseHippocampusMaleMethionine SulfoximineNeuronsRatsRats, Sprague-DawleySeizuresConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLobe epilepsyCentral nucleusMale Sprague-Dawley ratsPrevalence of depressionSprague-Dawley ratsGlutamine synthetase inhibitor methionine sulfoximineMeasures of anhedoniaRight CeA.Seizure activityAnhedonic behaviorDentate gyrusMedial amygdalaSucrose preferenceRat modelCommon causeAstrocytic enzymeBasolateral amygdalaLateral amygdalaOsmotic pumpPatientsEpilepsyAmygdalaEffects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy
Dhaher R, Wang H, Gruenbaum SE, Tu N, Lee TS, Zaveri HP, Eid T. Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy Research 2015, 115: 45-54. PMID: 26220375, PMCID: PMC4677790, DOI: 10.1016/j.eplepsyres.2015.05.005.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLateral ventricleLobe epilepsyDentate gyrusEntorhinal cortexDeep entorhinal cortexEntorhinal-hippocampal areaWeek recording periodSite-specific infusionPhosphate-buffered salineDays of infusionAdult laboratory ratsRecording periodMethionine sulfoximineSeizure severitySeizure activitySevere seizuresMetabolism of glutamateRat modelSynaptic transmissionAnatomical distributionHippocampal formationAngular bundle
2003
A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories
De Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T, Spencer DD. A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories. Epilepsia 2003, 44: 677-687. PMID: 12752467, DOI: 10.1046/j.1528-1157.2003.32701.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultApoptosisCell CountCulture TechniquesDentate GyrusDynorphinsElectroencephalographyEpilepsy, Temporal LobeEvoked PotentialsFemaleFollow-Up StudiesHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleNeuronsNeuropeptide YReference ValuesRetrospective StudiesSclerosisSomatostatinSubstance PTreatment OutcomeConceptsIntractable temporal lobe epilepsyTemporal lobe epilepsyDentate granule cellsLobe epilepsySurgical outcomesNeuronal lossNeuronal densityGranule cellsDentate gyrusNonsclerotic hippocampiRetrospective analysisHippocampal subfieldsHuman temporal lobe epilepsyBasis of pathophysiologyEvidence of sclerosisSignificant neuronal lossExtensive neuronal lossSharp electrode recordingsPatient subcategoriesSignificant hyperexcitabilityAutopsy controlsHippocampal pathologyNeuropeptide YImmunohistochemical characteristicsSubstance P