2022
A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentGraph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide risk
2021
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2009
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder. Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.Peer-Reviewed Original ResearchConceptsPerigenual anterior cingulate cortexHealthy comparison subjectsBipolar disorderFunctional magnetic resonance imagingDiffusion tensor imagingFunctional connectivityWhite matterFractional anisotropyHC groupPerigenual anterior cingulateAnterior cingulate cortexMagnetic resonance imagingGray matter structuresRegional fractional anisotropyWhite matter connectivityEmotional processingFunctional connectivity measuresSignificant positive associationBD groupComparison subjectsAnterior cingulateCingulate cortexResonance imagingSignificant associationBrain regions