2003
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Wu X, Yu H, Makan N, Spitz M. Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk. Methods In Molecular Medicine 2003, 75: 279-287. PMID: 12407747, DOI: 10.1385/1-59259-324-0:279.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBleomycinChromatidsChromosome AberrationsEnzyme-Linked Immunosorbent AssayHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IILung NeoplasmsLymphocytesMutagenicity TestsMutagensPredictive Value of TestsRisk FactorsConceptsInsulin-like growth factorSignal transduction pathwaysGrowth factorCell cycle progressionCell membrane receptorsTransduction pathwaysBcl proteinsMAP kinaseLung cancer cellsIGF-1 receptorCell deathMembrane receptorsS phaseAntiproliferative moleculesBinding of IGFBax proteinCell proliferationLung cancer riskImportant functionsProteinCancer cellsCyclin D1Retinoic acidTypes of peptidesMitogenic action
2000
Joint Effect of Insulin-Like Growth Factors and Mutagen Sensitivity in Lung Cancer Risk
Wu X, Yu H, Amos C, Hong W, Spitz M. Joint Effect of Insulin-Like Growth Factors and Mutagen Sensitivity in Lung Cancer Risk. Journal Of The National Cancer Institute 2000, 92: 737-743. PMID: 10793110, DOI: 10.1093/jnci/92.9.737.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBleomycinCase-Control StudiesChromosome AberrationsData Interpretation, StatisticalFemaleHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IILung NeoplasmsLymphocytesMaleMutagenicity TestsMutagensRisk FactorsSomatomedinsConceptsIGF-binding protein-3Lung cancer riskLung cancerCancer riskHigher IGFOdds ratioBPDE sensitivityInsulin-like growth factorMutagen sensitivityLevels of IGFPeripheral blood lymphocyte culturesLung cancer patientsSpecific histologic typesBleomycin sensitivityBlood lymphocyte culturesProliferation potentialHistologic typeTumor stageCancer patientsControl subjectsIGF-IIRisk factorsGenetic instabilityHumoral factorsLymphocyte culturesJoint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk
Wu X, Yu H, Amos C, Hong W, Spitz M. Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. Growth Hormone & IGF Research 2000, 10: s26-s27. PMID: 10984281, DOI: 10.1016/s1096-6374(00)90012-1.Peer-Reviewed Original Research