2014
The KRAS-Variant and miRNA Expression in RTOG Endometrial Cancer Clinical Trials 9708 and 9905
Lee LJ, Ratner E, Uduman M, Winter K, Boeke M, Greven KM, King S, Burke TW, Underhill K, Kim H, Boulware RJ, Yu H, Parkash V, Lu L, Gaffney D, Dicker AP, Weidhaas J. The KRAS-Variant and miRNA Expression in RTOG Endometrial Cancer Clinical Trials 9708 and 9905. PLOS ONE 2014, 9: e94167. PMID: 24732316, PMCID: PMC3986055, DOI: 10.1371/journal.pone.0094167.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskType 2 endometrial cancerEndometrial cancerKRAS-variantCancer riskLymphovascular invasionSurvival outcomesTumor biologyType 1 endometrial cancerEndometrial cancer trialsOverall survival rateMiRNA expressionAge-matched controlsCase-control analysisFunctional germline variantsClinical characteristicsPatient ageTumor characteristicsCancer trialsTumor specimensSurvival rateType 1Germline variantsMiRNA expression levelsCancer
2011
Genotypes and phenotypes of IGF-I and IGFBP-3 in breast tumors among Chinese women
Qian B, Zheng H, Yu H, Chen K. Genotypes and phenotypes of IGF-I and IGFBP-3 in breast tumors among Chinese women. Breast Cancer Research And Treatment 2011, 130: 217. PMID: 21562710, DOI: 10.1007/s10549-011-1552-9.Peer-Reviewed Original ResearchConceptsBreast cancer riskIGFBP-3 genotypesIGFBP-3 single nucleotide polymorphismsCancer riskChinese womenIGFBP-3Single nucleotide polymorphismsBreast cancerBreast tumorsTumor samplesLocal breast tissuesBreast cancer patientsIGF-I activityER-negative tumorsUnconditional logistic regressionCase-control studyFresh tumor samplesAge-matched controlsWilcoxon rank sum testRank sum testHigher peptide levelsIGFBP-3 geneIGF-I geneNegative tumorsCancer patients
2010
A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk
Ratner E, Lu L, Boeke M, Barnett R, Nallur S, Chin LJ, Pelletier C, Blitzblau R, Tassi R, Paranjape T, Hui P, Godwin AK, Yu H, Risch H, Rutherford T, Schwartz P, Santin A, Matloff E, Zelterman D, Slack FJ, Weidhaas JB. A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk. Cancer Research 2010, 70: 6509-6515. PMID: 20647319, PMCID: PMC2923587, DOI: 10.1158/0008-5472.can-10-0689.Peer-Reviewed Original ResearchConceptsOvarian cancerKRAS-variantOC patientsCancer riskRisk of OCIndependent case-control analysesCase-control studyOvarian cancer syndromeCase-control analysisFamily membersAdvanced diseaseWomen's cancersRisk factorsBRCA2 mutationsHBOC patientsOC casesIndependent cohortHBOC familiesHereditary breastSolid tumorsCancer syndromesKRAS oncogeneVariant allelesPatientsCancerABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case–Control Study
Risch HA, Yu H, Lu L, Kidd MS. ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case–Control Study. Journal Of The National Cancer Institute 2010, 102: 502-505. PMID: 20181960, PMCID: PMC2902822, DOI: 10.1093/jnci/djq007.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAdultAgedAged, 80 and overAntibodies, BacterialAntigens, BacterialBacterial ProteinsCase-Control StudiesConfounding Factors, EpidemiologicConnecticutEnzyme-Linked Immunosorbent AssayFemaleHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMiddle AgedOdds RatioPancreatic NeoplasmsConceptsNon-O blood typeH pylori seropositivityCase-control studyPancreatic cancerPylori seropositivityABO blood groupEnzyme-linked immunosorbent assayBlood typeBlood groupPopulation-based case-control studyNon-O blood groupControl subjects frequencyH pylori colonizationVirulence protein CagAHelicobacter pylori seropositivityPancreatic cancer riskO blood typeRandom digit dialingCagA seropositivityCase patientsH pyloriControl subjectsRisk factorsPylori colonizationCancer riskA genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nature Genetics 2010, 42: 224-228. PMID: 20101243, PMCID: PMC2853179, DOI: 10.1038/ng.522.Peer-Reviewed Original Research
2009
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox Jr J, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, González CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nature Genetics 2009, 41: 986-990. PMID: 19648918, PMCID: PMC2839871, DOI: 10.1038/ng.429.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAllelesCase-Control StudiesChromosomes, Human, Pair 9Cohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenotypeHaplotypesHumansIntronsLinkage DisequilibriumLogistic ModelsMaleOdds RatioPancreatic NeoplasmsPolymorphism, Single NucleotideProspective StudiesRisk FactorsUnited States
2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohortAdipokine genes and prostate cancer risk
Moore SC, Leitzmann MF, Albanes D, Weinstein SJ, Snyder K, Virtamo J, Ahn J, Mayne ST, Yu H, Peters U, Gunter MJ. Adipokine genes and prostate cancer risk. International Journal Of Cancer 2008, 124: 869-876. PMID: 19035456, PMCID: PMC2879625, DOI: 10.1002/ijc.24043.Peer-Reviewed Original ResearchConceptsProstate cancer riskProstate cancerCancer riskOdds ratioIGF-1Prostate carcinogenesisADIPOQ geneBaseline blood drawCase-control studyAdipocyte-derived cytokineIGFBP-3Serum insulinLEP geneBlood drawFinnish menIntervention groupLarge cohortGG genotypeRelative oddsAdipokine genesAA genotypeCancerVariant allelesA alleleLogistic regressionInsulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History
Harris T, Burk R, Yu H, Minkoff H, Massad L, Watts D, Zhong Y, Gange S, Kaplan R, Anastos K, Levine A, Moxley M, Xue X, Fazzari M, Palefsky J, Strickler H. Insulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 245-248. PMID: 18199731, DOI: 10.1158/1055-9965.epi-07-0686.Peer-Reviewed Original ResearchConceptsOncogenic human papillomavirusHuman papillomavirusNatural historyCervical neoplasiaInsulin-like growth factor (IGF) axisHuman papillomavirus (HPV) natural historyInsulin-like growth factorBaseline serum specimensDNA PCR testingOncogenic HPV infectionIGF-I levelsHigher serum levelsGrowth factor axisTotal IGFHPV infectionIGFBP-3Serum levelsCervical cancerHigher IGFIGF axisViral causeCervical cytologyCommon cancerProspective dataAbundant IGFBP
2007
Insulin Resistance–Related Gene Polymorphisms and Risk of Prostate Cancer
Moore SC, Leitzmann MF, Weinstein SJ, Snyder K, Albanes D, Virtamo J, Graubard BI, Mayne ST, Yu H, Peters U, Gunter MJ. Insulin Resistance–Related Gene Polymorphisms and Risk of Prostate Cancer. Cancer Epidemiology Biomarkers & Prevention 2007, 16: 1315-1317. PMID: 17548707, DOI: 10.1158/1055-9965.epi-07-0191.Peer-Reviewed Original ResearchEnergy balance, insulin resistance biomarkers, and breast cancer risk
Fair A, Dai Q, Shu X, Matthews C, Yu H, Jin F, Gao Y, Zheng W. Energy balance, insulin resistance biomarkers, and breast cancer risk. Cancer Epidemiology 2007, 31: 214-219. PMID: 17646056, PMCID: PMC1994998, DOI: 10.1016/j.cdp.2007.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAsian PeopleBiomarkersBody Mass IndexBreast NeoplasmsCase-Control StudiesChinaC-PeptideEnergy IntakeEnergy MetabolismExerciseFemaleHumansInsulin ResistanceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMiddle AgedMotor ActivityRisk AssessmentRisk FactorsWaist-Hip RatioConceptsInsulin-like growth factorBreast cancer riskExercise/sports activitiesShanghai Breast Cancer StudyBody mass indexInsulin resistance biomarkersC-peptideCancer riskIGFBP-3Breast cancerLevels of IGFEnergy intakeInsulin growth factor binding protein 3Growth factor binding protein 3Chinese womenResistance biomarkersInsulin-like growth factor-1C-peptide levelsBreast cancer preventionPhysical activity statusSports activitiesTotal energy intakeBody fat distributionCase-control studyBreast cancer cases
2004
Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women
Wen W, Gao Y, Shu X, Yu H, Cai Q, Smith J, Zheng W. Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women. International Journal Of Cancer 2004, 113: 307-311. PMID: 15386404, DOI: 10.1002/ijc.20571.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerPremenopausal womenCancer riskPopulation-based case-control studyAge frequency-matched controlsChinese womenIncident breast cancer casesPlasma IGF-I levelsInsulin-like growth factorIGF-I levelsFrequency-matched controlsCase-control studyBreast cancer casesAssociation of IGFDose-response mannerMeta-analysis resultsBreast cancer susceptibilityIGF-I geneSignificant genetic factorInsulin-like growth factor-I gene polymorphismPlasma IGFCancer casesGeneral populationGene polymorphismsReports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk
Sanderson M, Shu X, Yu H, Dai Q, Malin A, Gao Y, Zheng W. Reports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk. Nutrition And Cancer 2004, 50: 8-15. PMID: 15572292, DOI: 10.1207/s15327914nc5001_2.Peer-Reviewed Original ResearchConceptsIGF-I levelsShanghai Breast Cancer StudyIGFBP-3 levelsSoy protein intakeBreast cancer riskCancer riskProtein intakeBreast cancerInsulin-like growth factor-binding protein-3 levelsPopulation-based case-control studyIncident breast cancer casesPremenopausal breast cancer riskPopulation-based cancer registriesBreast cancer cell growthInsulin-like growth factorPremenopausal breast cancerProtein-3 levelsEffects of IGFCase-control studyBreast cancer casesInsulin-like growthCancer cell growthBreast Cancer StudyPostmenopausal womenCancer RegistryGenetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
Ren Z, Cai Q, Shu X, Cai H, Li C, Yu H, Gao Y, Zheng W. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 1290-5. PMID: 15298948, DOI: 10.1158/1055-9965.1290.13.8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionBase SequenceBiomarkers, TumorBreast NeoplasmsCase-Control StudiesChinaConfidence IntervalsFemaleGenetic Predisposition to DiseaseHumansIncidenceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsMiddle AgedMolecular Sequence DataOdds RatioPolymerase Chain ReactionPolymorphism, GeneticPopulation SurveillanceReference ValuesRisk AssessmentConceptsInsulin-like growth factorIGFBP-3 protein levelsBreast cancer riskBreast cancerVariant allelesIGFBP3 polymorphismsIGFBP-3IGFBP3 geneCancer riskElevated riskRisk genotypesActions of IGFsIncident breast cancer patientsChinese womenIGFBP-3 levelsIGF binding proteinBreast cancer patientsGenetic polymorphismsIGFBP-3 proteinProtein levelsCase-control studyDose-response mannerCancer patientsOdds ratioPolymorphism ACorrelation of Blood Sex Steroid Hormones with Body Size, Body Fat Distribution, and Other Known Risk Factors for Breast Cancer in Post-Menopausal Chinese Women
Boyapati S, Shu X, Gao Y, Dai Q, Yu H, Cheng J, Jin F, Zheng W. Correlation of Blood Sex Steroid Hormones with Body Size, Body Fat Distribution, and Other Known Risk Factors for Breast Cancer in Post-Menopausal Chinese Women. Cancer Causes & Control 2004, 15: 305-311. PMID: 15090725, DOI: 10.1023/b:caco.0000024256.48104.50.Peer-Reviewed Original ResearchConceptsEndogenous sex hormonesBreast cancer risk factorsCancer risk factorsSex hormonesHormone levelsRisk factorsBreast cancerReproductive factorsPopulation-based case-control studyEndogenous sex hormone levelsPost-menopausal healthy womenShanghai Breast Cancer StudyKnown Risk FactorsPost-menopausal Chinese womenSex hormone levelsBody fat distributionDietary macronutrient intakeBreast cancer riskCase-control studySex steroid hormonesLevels of testosteroneBreast Cancer StudyWaist circumferenceHealthy womenHip circumferenceEvaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma
Malin A, Dai Q, Yu H, Shu X, Jin F, Gao Y, Zheng W. Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma. Cancer 2004, 100: 694-700. PMID: 14770423, PMCID: PMC1780270, DOI: 10.1002/cncr.20023.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast carcinomaC-peptideIGFBP-3Insulin resistanceIGF-1Odds ratioShanghai Breast Cancer StudyGrowth factorBreast carcinoma riskHigh blood levelsBreast carcinoma casesCase-control pairsDose-response mannerBreast Cancer StudyCurrent studyHighest quartileBlood levelsLowest quartileCarcinoma casesCarcinoma riskHigh riskHigh levelsCarcinomaSignificant twofoldTLK1B is elevated with eIF4E overexpression in breast cancer
Norton K, McClusky D, Sen S, Yu H, Meschonat C, Debenedetti A, Li B. TLK1B is elevated with eIF4E overexpression in breast cancer. Journal Of Surgical Research 2004, 116: 98-103. PMID: 14732354, DOI: 10.1016/j.jss.2003.08.001.Peer-Reviewed Original Research
2003
Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women.
Zheng S, Zheng W, Chang B, Shu X, Cai Q, Yu H, Dai Q, Xu J, Gao Y. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Cancer Research 2003, 63: 7624-9. PMID: 14633679.Peer-Reviewed Original ResearchConceptsBreast cancer riskEndogenous estrogen exposureEstrogen exposureCancer riskSteroid sex hormonesSex hormonesBreast cancerSingle nucleotide polymorphismsLong-term estrogen exposureChinese womenEstrogen receptor beta geneShanghai Breast Cancer StudyBreast Cancer StudyPostmenopausal womenFamily historyEstrogen synthesisCommon sequence variantsElevated riskGG genotypePotential synergistic effectsSequence variantsESR2 geneStrong associationWomenCancerRelation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States)
Li L, Yu H, Schumacher F, Casey G, Witte J. Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States). Cancer Causes & Control 2003, 14: 721-726. PMID: 14674736, DOI: 10.1023/a:1026383824791.Peer-Reviewed Original ResearchConceptsIGFBP-3 molar ratioInsulin-like growth factorIGFBP-3Prostate cancerHigher IGFOdds ratioSibling-matched case-control studySerum insulin-like growth factorInsulin-like growth factor IProtein 3Growth factorIGFBP-3 associationSerum IGF levelsEffects of IGFConfidence intervalsImportant risk factorCase-control studyConditional logistic regressionGrowth factor IProstatic epithelial cellsAdvanced diseaseSerum IGFIGF levelsAggressive diseaseRisk factorsUrinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics.
Dai Q, Franke A, Yu H, Shu X, Jin F, Hebert J, Custer L, Gao Y, Zheng W. Urinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 497-502. PMID: 12814993.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnthropometryBiomarkers, TumorBody Mass IndexBody WeightBreast NeoplasmsCase-Control StudiesChinaDehydroepiandrosterone SulfateEatingEstrogensFemaleFibroadenomaHumansIsoflavonesMenopauseMiddle AgedPhytoestrogensPlant PreparationsRisk FactorsSex Hormone-Binding GlobulinStatistics as TopicTestosteroneWomen's HealthConceptsBody mass indexBreast cancer riskUrinary phytoestrogen excretionSteroid sex hormonesSex hormonesCancer riskSteroid hormonesUrinary isoflavonoidsBlood levelsInverse associationBreast cancerExcretion rateEndogenous steroid sex hormonesHigher body mass indexMammalian lignansConditional logistic regression modelsPotential confounding factorsHigh blood concentrationsCase-control pairsPotential protective associationLogistic regression modelsPostmenopausal womenMorning bloodMass indexHip ratio