2012
PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer
Su D, Xu H, Feng J, Gao Y, Gu L, Ying L, Katsaros D, Yu H, Xu S, Qi M. PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer. Journal Of Translational Medicine 2012, 10: 31. PMID: 22369209, PMCID: PMC3305474, DOI: 10.1186/1479-5876-10-31.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overApoptosisApoptosis Regulatory ProteinsBlotting, WesternCalcium-Binding ProteinsCarcinoma, Ovarian EpithelialCell CycleCell Line, TumorCell ProliferationDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGene SilencingGenetic VectorsHumansKaplan-Meier EstimateLentivirusMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisNeoplasms, Glandular and EpithelialOvarian NeoplasmsRNA, MessengerRNA, Small InterferingStatistics, NonparametricTransfectionConceptsEpithelial ovarian cancerProgression-free survivalOvarian cancer progressionOvarian cancer cellsOvarian cancerFree survivalOverall survivalIndependent predictorsKaplan-Meier survival analysisEpithelial ovarian cancer tissuesMetastatic ovarian cancer cellsCancer progressionPDCD6 expressionResidual tumor sizeClinical pathological factorsEpithelial ovarian cancer correlatesCancer cellsOvarian cancer correlatesOvarian cancer tissuesHistologic typeClinical progressionTumor sizeDisease stageTumor gradeCancer correlates
2005
A Prospective Trial on Initiation Factor 4E (eIF4E) Overexpression and Cancer Recurrence in Node-Positive Breast Cancer
McClusky D, Chu Q, Yu H, DeBenedetti A, Johnson L, Meschonat C, Turnage R, McDonald J, Abreo F, Li B. A Prospective Trial on Initiation Factor 4E (eIF4E) Overexpression and Cancer Recurrence in Node-Positive Breast Cancer. Annals Of Surgery 2005, 123: 278-286. PMID: 16192819, PMCID: PMC1402342, DOI: 10.1097/01.sla.0000184224.55949.90.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBlotting, WesternBreast NeoplasmsElectrophoresis, Polyacrylamide GelEukaryotic Initiation Factor-4EFemaleFollow-Up StudiesHumansIncidenceLymph NodesLymphatic MetastasisMastectomy, Extended RadicalMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingProspective StudiesRisk FactorsSurvival RateConceptsNode-positive breast cancerBreast cancerCancer recurrenceHighest tertileEIF4E overexpressionProspective trialNodal statusHigher cancer recurrence rateCancer-related death rateCox proportional hazards modelNode-positive diseaseKaplan-Meier methodCancer recurrence rateLog-rank testCancer-related deathProportional hazards modelRelative risk increaseHigh eIF4E overexpressionRelative risk calculationsMedian followDisease recurrenceIndependent predictorsIntermediate tertileNoncancer patientsProspective study
2004
TLK1B is elevated with eIF4E overexpression in breast cancer
Norton K, McClusky D, Sen S, Yu H, Meschonat C, Debenedetti A, Li B. TLK1B is elevated with eIF4E overexpression in breast cancer. Journal Of Surgical Research 2004, 116: 98-103. PMID: 14732354, DOI: 10.1016/j.jss.2003.08.001.Peer-Reviewed Original Research
2002
Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome
Li B, Gruner J, Abreo F, Johnson L, Yu H, Nawas S, McDonald J, DeBenedetti A. Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome. Annals Of Surgery 2002, 235: 732-739. PMID: 11981220, PMCID: PMC1422500, DOI: 10.1097/00000658-200205000-00016.Peer-Reviewed Original ResearchConceptsCancer-related deathCancer recurrenceRelative riskBreast cancerIndependent predictorsReceptor statusProtein elevationHigh eIF4EMenopausal statusTumor sizeTumor gradeHigher cancer recurrence rateImportant independent prognostic markerKaplan-Meier survival curvesCox proportional hazards modelStage 1Progesterone receptor statusBreast cancer outcomesSmall retrospective studiesStage of diseaseEstrogen receptor statusCancer recurrence rateIndependent prognostic markerLog-rank testBreast cancer recurrence
1996
Prostate specific antigen — a new constituent of breast cyst fluid
Diamandis E, Yu H, López-Otín C. Prostate specific antigen — a new constituent of breast cyst fluid. Breast Cancer Research And Treatment 1996, 38: 259-264. PMID: 8739078, DOI: 10.1007/bf01806144.Peer-Reviewed Original ResearchConceptsProstate-specific antigenBreast cyst fluidCyst fluidSpecific antigenFree prostate-specific antigenBreast cystic diseasePSA presenceWestern blot analysisCystic diseaseBreast cancerNormal breastCutoff levelΑ1-antichymotrypsinMore studiesBlot analysisHigh-performance liquid chromatographyAntigenFrequent componentPerformance liquid chromatographySerine proteasesLiquid chromatographyCancerBreastDiseaseProstaglandin D2 synthase: a component of human amniotic fluid and its association with fetal abnormalities.
Melegos D, Yu H, Diamandis E. Prostaglandin D2 synthase: a component of human amniotic fluid and its association with fetal abnormalities. Clinical Chemistry 1996, 42: 1042-1050. PMID: 8674187, DOI: 10.1093/clinchem/42.7.1042.Peer-Reviewed Original ResearchConceptsProstate-specific antigenAmniotic fluidHuman amniotic fluidGestational week 12Western blot analysisAbnormal pregnanciesPGD2 synthaseStrong immunoreactive bandWeek 12Monoclonal anti-PSA antibodiesRenal abnormalitiesProstaglandin D2 synthaseTrisomic fetusesPGD2 productionFetal abnormalitiesAnti-PSA antibodiesImmunoreactive bandsBlot analysisSemiquantitative analysisFetusesAbnormalitiesPolyclonal antibodiesImmunoreactive speciesAntibodiesAmino acid sequence analysis
1995
Prostate-specific antigen in milk of lactating women.
Yu H, Diamandis E. Prostate-specific antigen in milk of lactating women. Clinical Chemistry 1995, 41: 54-58. PMID: 7529146, DOI: 10.1093/clinchem/41.1.54.Peer-Reviewed Original ResearchConceptsProstate-specific antigenBreast milkPSA concentrationTotal prostate-specific antigenCancerous prostatic tissueMicrograms/LConditions of stimulationWestern blot analysisWeeks postdeliveryPresence of PSANormal breastProstatic tissueAmniotic fluidMother's ageBreast tumorsFemale breastSteroid hormonesPSA-alphaSensitive prostate specific antigenGrowth factorSpecific markersPostdeliveryBlot analysisBreastAntigen
1994
Induction of prostate specific antigen production by steroids and tamoxifen in breast cancer cell lines
Yu H, Diamandis E, Zarghami N, Grass L. Induction of prostate specific antigen production by steroids and tamoxifen in breast cancer cell lines. Breast Cancer Research And Treatment 1994, 32: 291-300. PMID: 7532467, DOI: 10.1007/bf00666006.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate-specific antigen (PSA) productionSpecific antigen productionBreast cancer cell linesCell linesCell line TCancer cell linesPSA productionNew therapiesSpecific antigenBreast tumorsT-47DAntigen productionSuch stimulationMCF-7AndrogensPrevious reportsInductionGlucocorticosteroidsMineralocorticosteroidsData supportProgestinsPrognosisTamoxifenAntiestrogens