2010
Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk
Qian B, Zhang H, Zhang L, Zhou X, Yu H, Chen K. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer 2010, 73: 138-146. PMID: 21195504, DOI: 10.1016/j.lungcan.2010.11.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungDNA RepairDNA Repair EnzymesDNA-Binding ProteinsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansLung NeoplasmsMaleMiddle AgedPolymorphism, GeneticRisk FactorsSmokingXeroderma Pigmentosum Group A ProteinXeroderma Pigmentosum Group D ProteinYoung AdultConceptsNon-small cell lung cancerLung cancer riskSquamous cell carcinomaLung cancerCancer riskCell carcinomaSingle nucleotide polymorphismsHigh riskGenetic polymorphismsNon-small cell lung cancer riskRisk of NSCLCCell lung cancer riskHigher lung cancer riskCell lung cancerVariant AA genotypeDominant risk factorNumerous epidemiological studiesLogistic regression modelsDNA repair pathway genesYoung smokersNSCLC casesSubgroup analysisRisk factorsHealthy controlsStratified analysis
2007
IGF-I in epithelial ovarian cancer and its role in disease progression
Brokaw J, Katsaros D, Wiley A, Lu L, Su D, Sochirca O, de la Longrais IA, Mayne S, Risch H, Yu H. IGF-I in epithelial ovarian cancer and its role in disease progression. Growth Factors 2007, 25: 346-354. PMID: 18236213, DOI: 10.1080/08977190701838402.Peer-Reviewed Original ResearchConceptsIGF-I transcriptsDisease progressionOvarian cancerTumor progressionEpithelial ovarian cancer patientsIGF-I mRNA expressionInsulin-like growth factorParacrine/autocrine regulationIGF-I activityEpithelial ovarian cancerIGF-I actionOvarian cancer patientsFresh tumor samplesIGF-I expressionIGF-I mRNAOvarian cancer progressionEnzyme-linked immunosorbentParacrine/autocrineTotal IGFFree IGFClinicopathologic featuresCA polymorphismCancer patientsReal-time PCRElevated risk
2005
Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival
Beeghly A, Katsaros D, Chen H, Fracchioli S, Zhang Y, Massobrio M, Risch H, Jones B, Yu H. Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival. Gynecologic Oncology 2005, 100: 330-337. PMID: 16199080, DOI: 10.1016/j.ygyno.2005.08.035.Peer-Reviewed Original ResearchConceptsOvarian cancer treatmentDisease progressionGSTP1 genotypesGST polymorphismsPrimary epithelial ovarian cancerCox proportional hazards regressionFunctional polymorphismsGSTP1 Ile/IleCancer treatmentGSTP1 Ile/ValGlutathione S-transferase polymorphismsGSTM1 null patientsPost-operative chemotherapySubgroup of patientsProportional hazards regressionEpithelial ovarian cancerOvarian cancer survivalEffect of chemotherapyOvarian cancer prognosisOvarian cancer progressionVal/ValIle/IleIle/ValOverall survivalTumor characteristics
2004
Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women
Wen W, Gao Y, Shu X, Yu H, Cai Q, Smith J, Zheng W. Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women. International Journal Of Cancer 2004, 113: 307-311. PMID: 15386404, DOI: 10.1002/ijc.20571.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerPremenopausal womenCancer riskPopulation-based case-control studyAge frequency-matched controlsChinese womenIncident breast cancer casesPlasma IGF-I levelsInsulin-like growth factorIGF-I levelsFrequency-matched controlsCase-control studyBreast cancer casesAssociation of IGFDose-response mannerMeta-analysis resultsBreast cancer susceptibilityIGF-I geneSignificant genetic factorInsulin-like growth factor-I gene polymorphismPlasma IGFCancer casesGeneral populationGene polymorphismsGenetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
Ren Z, Cai Q, Shu X, Cai H, Li C, Yu H, Gao Y, Zheng W. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 1290-5. PMID: 15298948, DOI: 10.1158/1055-9965.1290.13.8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionBase SequenceBiomarkers, TumorBreast NeoplasmsCase-Control StudiesChinaConfidence IntervalsFemaleGenetic Predisposition to DiseaseHumansIncidenceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsMiddle AgedMolecular Sequence DataOdds RatioPolymerase Chain ReactionPolymorphism, GeneticPopulation SurveillanceReference ValuesRisk AssessmentConceptsInsulin-like growth factorIGFBP-3 protein levelsBreast cancer riskBreast cancerVariant allelesIGFBP3 polymorphismsIGFBP-3IGFBP3 geneCancer riskElevated riskRisk genotypesActions of IGFsIncident breast cancer patientsChinese womenIGFBP-3 levelsIGF binding proteinBreast cancer patientsGenetic polymorphismsIGFBP-3 proteinProtein levelsCase-control studyDose-response mannerCancer patientsOdds ratioPolymorphism A
2003
Genotype–phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene
Kato I, Eastham J, Li B, Smith M, Yu H. Genotype–phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. European Journal Of Epidemiology 2003, 18: 203-209. PMID: 12800944, DOI: 10.1023/a:1023379100539.Peer-Reviewed Original ResearchMeSH KeywordsAllelesDinucleotide RepeatsGenotypeHumansInsulin-Like Growth Factor IPhenotypePolymorphism, GeneticConceptsPlasma IGF-I levelsIGF-I levelsInsulin-like growthPlasma IGFHospital-based case-control studyCase-control studyGenotype-phenotype analysisCA repeat lengthInverse associationOverall functional significanceProstate cancerStudy subjectsHealthy individualsChance findingWhite womenIGFRacial subgroupsDirect sequencingPositive associationCancerBlack menNumber of CaFunctional significanceAssociationPolymorphic CA
2001
Polymorphic CA repeats in the IGF-I gene and breast cancer
Yu H, Li B, Smith M, Shi R, Berkel H, Kato I. Polymorphic CA repeats in the IGF-I gene and breast cancer. Breast Cancer Research And Treatment 2001, 70: 117-122. PMID: 11768601, DOI: 10.1023/a:1012947027213.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsDinucleotide RepeatsFemaleGenotypeHumansInsulin-Like Growth Factor IMiddle AgedPolymorphism, GeneticConceptsBreast cancer patientsBreast cancerIGF-I geneCancer patientsCA repeatsUnconditional logistic regression analysisInsulin-like growth factorRole of IGFHigher odds ratioLogistic regression analysisHigher plasma IGFIGF-I genotypeBreast cancer cellsIGF-I polymorphismMenopausal statusPeripheral bloodPlasma IGFOdds ratioMedian numberNumber of CaCancerLarger studyAlcohol usePotent mitogenIGFSequence Analysis of the Human Kallikrein Gene Locus Identifies a Unique Polymorphic Minisatellite Element
Yousef G, Bharaj B, Yu H, Poulopoulos J, Diamandis E. Sequence Analysis of the Human Kallikrein Gene Locus Identifies a Unique Polymorphic Minisatellite Element. Biochemical And Biophysical Research Communications 2001, 285: 1321-1329. PMID: 11478802, DOI: 10.1006/bbrc.2001.5321.Peer-Reviewed Original ResearchConceptsHuman kallikrein gene locusKallikrein gene locusRepeat elementsGene locusLinkage analysisDNA fingerprintingDifferent repeat elementsEnhancers of genesGenomic areasRepetitive sequencesKallikrein locusUntranslated regionChromosome 19q13.4Sequence analysisChromosome 19q13Different allelesMinisatellitesLociDNA strandsSerine proteasesKallikrein geneGenes