The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency
Juul A, Møller S, Mosfeldt-Laursen E, Rasmussen M, Scheike T, Pedersen S, Kastrup K, Yu H, Mistry J, Rasmussen S, Müller J, Henriksen J, Skakkebæk N. The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 4408-4415. PMID: 9851786, DOI: 10.1210/jcem.83.12.5311.Peer-Reviewed Original ResearchConceptsAcid-labile subunitIGFBP-3GH deficiencyALS levelsHepatosplanchnic releaseNormal age-related rangesChildhood-onset GH deficiencyInsulin-like growth factorAge-related rangeSignificant arteriovenous gradientNormal GH responseGH secretory statusConcentrations of IGFLiver vein catheterizationGrowth hormone deficiencyCirculating ConcentrationsGH responseGHD patientsVein catheterizationSecretory statusArteriovenous gradientHormone deficiencyHealthy subjectsDiagnostic utilityIGF