2018
Food withdrawal alters the gut microbiota and metabolome in mice
Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Qu C, Ge K, Huang F, Hernandez B, Yu H, Panee J, Chen T, Jia W, Jia W. Food withdrawal alters the gut microbiota and metabolome in mice. The FASEB Journal 2018, 32: 4878-4888. PMID: 29620942, PMCID: PMC9292403, DOI: 10.1096/fj.201700614r.Peer-Reviewed Original ResearchConceptsHigh-fat dietFood withdrawalGut microbiotaObese miceWithdrawal altersAbundance of microbesHost metabolic changesFree fatty acid metabolismBeneficial effectsNormal chow groupAbundance of metabolitesNormal lean miceFatty acid metabolismPathogenic ProteobacteriaMolecular mechanismsBranched-chain amino acidsHost serum metabolomeChain amino acidsCecal microbiomeAmino acidsHFD groupHFD miceDietary interventionLean miceNormal mice
2016
Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer
Yu H, Irwin M. Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer. Energy Balance And Cancer 2016, 11: 251-264. DOI: 10.1007/978-3-319-41610-6_11.Peer-Reviewed Original ResearchDNA methylationTumor suppressor genePhysical activityEpigenetic regulationSuppressor geneCancer riskGenome-wide methylationBetter patient survivalBreast cancer patientsPro-inflammatory cytokinesBreast cancer riskSex steroid hormonesLower cancer riskMitogenic growth factorsEntire genomeMolecular mechanismsInsulin resistancePatient survivalCancer patientsMethylationMore profound impactsCancer preventionBreast cancerDisease outcomeHealthy individuals