2024
Detection of hepatocellular carcinoma methylation markers in salivary DNA
Mezzacappa C, Wang Z, Lu L, Risch H, Taddei T, Yu H. Detection of hepatocellular carcinoma methylation markers in salivary DNA. Bioscience Reports 2024, 44: bsr20232063. PMID: 38457142, PMCID: PMC10958141, DOI: 10.1042/bsr20232063.Peer-Reviewed Original ResearchHepatocellular carcinoma screeningCase patientsHepatocellular carcinomaControl subjectsDiagnosis of hepatocellular carcinomaAssociated with hepatocellular carcinomaScreening testSalivary DNASaliva-based testCpG sitesStudy of risk factorsSalivary DNA methylationDNA methylationViral hepatitisCirculating DNAAlterations to DNA methylationRisk factorsMethylation markersPatientsRegulation of cell cycle progressionBlood samplesCell cycle progressionAffected individualsAlternative to blood samplingMultiple comparisonsMechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis.
Xiang X, Bhowmick K, Shetty K, Ohshiro K, Yang X, Wong L, Yu H, Latham P, Satapathy S, Brennan C, Dima R, Chambwe N, Sharifova G, Cacaj F, John S, Crawford J, Huang H, Dasarathy S, Krainer A, He A, Amdur R, Mishra L. Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis. Genes & Cancer 2024, 15: 1-14. PMID: 38323119, PMCID: PMC10843195, DOI: 10.18632/genesandcancer.234.Peer-Reviewed Original ResearchHepatocellular carcinomaPyruvate kinase M2TGF-bPresence of hepatocellular carcinomaEarly detection of HCCRisk of hepatocellular cancerDetection of hepatocellular carcinomaAdvanced incurable stageRisk-stratifying biomarkersTGF-B pathwayAssociated with hepatocellular carcinomaProteomic markersEarly detectionBiologically relevant markersIncurable stageBlood-based biomarkersHepatocellular cancerRisk stratificationStratify riskNon-HCCClinical variablesBlood levelsLiver diseaseAnimal modelsBiological role
2022
Pathogenesis to management of hepatocellular carcinoma
Da B, Suchman K, Lau L, Rabiee A, He A, Shetty K, Yu H, Wong L, Amdur R, Crawford J, Fox S, Grimaldi G, Shah P, Weinstein J, Bernstein D, Satapathy S, Chambwe N, Xiang X, Mishra L. Pathogenesis to management of hepatocellular carcinoma. Genes & Cancer 2022, 13: 72-87. PMID: 36533190, PMCID: PMC9746873, DOI: 10.18632/genesandcancer.226.Peer-Reviewed Original ResearchHepatocellular carcinomaCommon primary liver cancerEarly-stage hepatocellular carcinomaLiver-directed therapiesPathogenesis of HCCPrimary liver cancerMetastatic hepatocellular carcinomaViable animal modelAdvanced diseaseLiver resectionSystemic therapyPoor prognosisRisk factorsHCC managementHistological classificationLiver cancerNew therapiesAnimal modelsTherapyTissue samplingRelevant biomarkersAlcohol useMolecular targetsCarcinomaPathogenesisAbstract 3378: Targeted serum proteomics identifies a signature for use in multivariable logistic regression modeling to predict HCC
Rao S, Amdur R, Xiyan X, Shetty K, Yu H, Wong L, Jogunoori W, Amin K, Latham P, Mishra L. Abstract 3378: Targeted serum proteomics identifies a signature for use in multivariable logistic regression modeling to predict HCC. Cancer Research 2022, 82: 3378-3378. DOI: 10.1158/1538-7445.am2022-3378.Peer-Reviewed Original ResearchPositive predictive valueMultivariate logistic regressionTargeted serum proteomicsArea under the curveHepatocellular carcinomaReceiver operating characteristicTGF-bAmerican Association for Cancer Research annual meetingsClinical variablesDetect early HCCLogistic regressionEarly stage HCCHigh-throughput proteomic assayPrediction of hepatocellular carcinomaStages of hepatocellular carcinomaTGF-B pathwayFollow-up study of patientsStage hepatocellular carcinomaNon-HCC groupDetect hepatocellular carcinomaHepatocellular carcinoma groupEarly HCCHepatocellular carcinoma patientsSerum proteomeStudy of patientsAbstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis
Bhowmick K, Amdur R, Xiang X, Yu H, Wong L, Rao S, He A, Amin K, Zaheer D, Narayan R, Satapathy S, Guha C, Latham P, Shetty K, Gough N, Mishra L. Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis. Cancer Research 2022, 82: 3379-3379. DOI: 10.1158/1538-7445.am2022-3379.Peer-Reviewed Original ResearchHepatocellular carcinomaLiver biopsyCirrhotic tissueStaining intensityAmerican Association for Cancer Research annual meetingsLogistic regression modelsDetection of hepatocellular carcinomaDiagnostic of hepatocellular carcinomaEarly detection of hepatocellular carcinomaMulti-cohort studyEvaluating biopsy samplesAnalysis of biopsy tissueAssociated with hepatocellular carcinomaTransforming growth factor-bDevelopment of hepatocellular carcinomaIndependent patient cohortHigh-risk groupGrowth factor BQuantitative IHCPatient cohortBiopsy tissueBiopsy samplesClinical trialsCirrhosisLoss of function