Associations of Insulin-Like Growth Factor (IGF)—I and IGF-Binding Protein—3 with HIV Disease Progression in Women
Strickler H, Fazzari M, Kovacs A, Isasi C, Napolitano L, Minkoff H, Gange S, Young M, Sharp G, Kaplan R, Cohen M, Gunter M, Harris T, Yu H, Schoenbaum E, Landay A, Anastos K. Associations of Insulin-Like Growth Factor (IGF)—I and IGF-Binding Protein—3 with HIV Disease Progression in Women. The Journal Of Infectious Diseases 2008, 197: 319-327. PMID: 18177247, PMCID: PMC3127259, DOI: 10.1086/524848.Peer-Reviewed Original ResearchConceptsHIV disease progressionT-cell count declineCell count declineDisease progressionIGFBP-3Count declineIGF axisHuman immunodeficiency virus (HIV) disease progressionInsulin-like growth factor (IGF) axisHigher IGFBP-3 levelsIGF-Binding Protein-3Low IGF-I levelsInsulin-like growth factorIGFBP-3 levelsUse of HAARTBaseline serum samplesIGF-I levelsIGF-binding proteinsGrowth factor axisHIV pathogenesisLymphocyte numbersSerum levelsThymic growthImmunodeficiency syndromeMultivariable model