2019
Common genetic variants have associations with human cortical brain regions and risk of schizophrenia
Bi X, Feng L, Wang S, Lin Z, Li T, Zhao B, Zhu H, Zhang H. Common genetic variants have associations with human cortical brain regions and risk of schizophrenia. Genetic Epidemiology 2019, 43: 548-558. PMID: 30941828, PMCID: PMC6559856, DOI: 10.1002/gepi.22203.Peer-Reviewed Original ResearchConceptsCortical regionsCortical brain regionsRisk of schizophreniaPrefrontal cortical regionsSymptom durationProdromal symptomsMental disordersSignificant associationBrain regionsCommon genetic variantsPhiladelphia Neurodevelopmental CohortPediatric imagingSchizophreniaNeurodevelopmental CohortCommon variantsHuman brainGenetic variantsHeritable mental disorderMagnetic resonanceAssociationWide association studyAssociation studiesGenetic effectsCohortSymptoms
2017
Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes
Bi X, Yang L, Li T, Wang B, Zhu H, Zhang H. Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes. Human Brain Mapping 2017, 38: 4088-4097. PMID: 28544218, PMCID: PMC5568842, DOI: 10.1002/hbm.23650.Peer-Reviewed Original Research
2011
Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI
Skup M, Zhu H, Wang Y, Giovanello KS, Lin JA, Shen D, Shi F, Gao W, Lin W, Fan Y, Zhang H, Initiative T. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI. NeuroImage 2011, 56: 890-906. PMID: 21356315, PMCID: PMC3085726, DOI: 10.1016/j.neuroimage.2011.02.060.Peer-Reviewed Original ResearchConceptsGrey matter atrophy patternsAlzheimer's Disease Neuroimaging InitiativeProbable Alzheimer's diseaseAlzheimer's diseaseAmnestic mild cognitive impairmentAtrophy patternsDisease Neuroimaging InitiativeLongitudinal magnetic resonance imaging (MRI) dataPredetermined brain regionsBilateral caudate nucleusAMCI groupBilateral middle temporal gyrusVoxel-wise analysisMild cognitive impairmentGray matter regionsMiddle temporal gyrusBilateral thalamusBrain atrophyStructural MRI dataHealthy controlsGrey matter dataMagnetic resonance imaging dataAD groupBilateral precuneusCaudate nucleus
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2002
A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children
Peterson BS, Vohr B, Kane MJ, Whalen DH, Schneider KC, Katz KH, Zhang H, Duncan CC, Makuch R, Gore JC, Ment LR. A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children. Pediatrics 2002, 110: 1153-1162. PMID: 12456913, DOI: 10.1542/peds.110.6.1153.Peer-Reviewed Original ResearchConceptsLanguage comprehension taskFunctional magnetic resonance imagingBrain activityLanguage comprehensionComprehension taskPreterm childrenIQ scoresFunctional magnetic resonance imaging studyLower verbal IQ scoresProcessing tasksSemantic processing taskAbnormal neural processingVerbal IQ scoresPoor language comprehensionCommunity control childrenMagnetic resonance imaging studyCognitive correlatesResonance imaging studySemantic processingNeural processingScanning taskFMRI scansLanguage processingControl childrenBrain structures
2000
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Peterson BS, Leckman JF, Tucker D, Scahill L, Staib L, Zhang H, King R, Cohen DJ, Gore JC, Lombroso P. Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders. JAMA Psychiatry 2000, 57: 364-372. PMID: 10768698, DOI: 10.1001/archpsyc.57.4.364.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesAttention-deficit/hyperactivity disorderAntistreptococcal antibody titersObsessive-compulsive disorderAntibody titersGanglia volumesStreptococcal infectionAntistreptococcal antibodiesPreliminary serological evidencePrior streptococcal infectionRecurrent streptococcal infectionsHyperactivity disorderPresence of ADHDBasal ganglia nucleiHigh antibody titersGlobus pallidus nucleusDSM-IV diagnosisStreptococcal exposurePallidus nucleusAntistreptolysin OOCD comorbiditySerological evidenceSusceptible personsTic disordersDiagnostic comorbidity
1999
An fMRI study of stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems
Peterson B, Skudlarski P, Gatenby J, Zhang H, Anderson A, Gore J. An fMRI study of stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biological Psychiatry 1999, 45: 1237-1258. PMID: 10349031, DOI: 10.1016/s0006-3223(99)00056-6.Peer-Reviewed Original ResearchConceptsAttentional subsystemsResponse selectionMotor planningAnterior cingulateNeural systemsFunctional magnetic resonance imagingImproved task performanceFactor analysisAnterior cingulate cortexAttentional resourcesAttentional systemInterference taskReceptive languageSignificant regional activationsTask performanceFMRI studyMultiple neural pathwaysMesial frontal cortexInformation processing moduleProcessing modelSensory tuningCingulate cortexFunctional connectivityRegional activationPathway strength
1998
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.Peer-Reviewed Original ResearchConceptsTic suppressionTourette syndromeTic symptomsBasal gangliaPathogenesis of ticsVoluntary tic suppressionMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySubcortical neural circuitsFunctional magnetic resonance imagingMagnetic resonance imagingConnected cortical regionsRegional signal changesImpaired modulationSignal changesFunctional debilityNeuronal activityResonance imagingAdult subjectsImaging studiesCortical regionsNeuropsychiatric disordersNeural circuitsSyndrome