2020
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins
Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Cedars MI, Hansen KR, Robinson R, Baker V, Usadi R, Dodson WC, Estes SJ, Kunselman A, Stetter C, Barnhart KT, Coward RM, Trussell JC, Krawetz SA, Santoro N, Huang H, Zhang H, Eisenberg E, Network R. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertility And Sterility 2020, 113: 1005-1013. PMID: 32386612, PMCID: PMC7376442, DOI: 10.1016/j.fertnstert.2019.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsChild BehaviorChild DevelopmentChild, PreschoolClomipheneCognitionFemaleFertilityFertility AgentsFollow-Up StudiesGesturesGonadotropinsHumansInfantInfertility, FemaleLetrozoleLive BirthMaleOvulation InductionPolycystic Ovary SyndromePregnancyProspective StudiesRandomized Controlled Trials as TopicRegistriesTreatment OutcomeUnited StatesWeight GainConceptsGN groupMultiple pregnancy rateProspective cohort studyPolycystic ovary syndromeChildren of womenInfertility trialsUnexplained infertilityCohort studyII studyMultiple gestationsOvary syndromeHealth centersInfertility treatmentPregnancy rateInfertility therapyMAIN OUTCOMELTZ groupLetrozoleMacArthur-Bates Communicative Development InventoriesAcademic health centersGonadotropinAbnormal scoresClomipheneCC groupDevelopmental QuestionnaireAndrogenicity and fertility treatment in women with unexplained infertility
Wang ET, Diamond MP, Alvero R, Casson P, Christman GM, Coutifaris C, Hansen KR, Sun F, Legro RS, Robinson RD, Usadi RS, Pisarska MD, Santoro NF, Zhang H, Network I. Androgenicity and fertility treatment in women with unexplained infertility. Fertility And Sterility 2020, 113: 636-641. PMID: 32192596, PMCID: PMC7088440, DOI: 10.1016/j.fertnstert.2019.10.034.Peer-Reviewed Original ResearchConceptsLive birth rateBody mass indexUnexplained infertilityClinical pregnancyMass indexPregnancy lossClinical markersLive birthsAndrogenic activityFree androgen index valuesHigher body mass indexMultivariable logistic regression modelMultiple Intrauterine GestationsNormal uterine cavityHigh waist circumferenceOvarian stimulation treatmentPatent fallopian tubesBirth rateLogistic regression modelsAndrogen markersSerum TTOvarian stimulationRegular mensesInfertility populationIntrauterine gestation
2019
Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index
Rios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG. Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz012. PMID: 31586179, PMCID: PMC7024739, DOI: 10.1210/clinem/dgz012.Peer-Reviewed Original ResearchConceptsHomeostasis model assessment-insulin resistancePolycystic ovary syndromeAnti-Mullerian hormoneBody mass indexC-reactive proteinUnexplained infertilityWaist circumferenceOVA groupLipoprotein cholesterolMass indexRelationship of AMHModel assessment-insulin resistanceHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolSite-adjusted modelsAssessment-insulin resistanceAntral follicle countCardio-metabolic healthReproductive-aged womenMultivariable linear regression modelsReproductive-age womenClinical populationsLow-density lipoproteinCardiometabolic agingCardiometabolic indices
2016
Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary Syndrome
Mumford SL, Legro RS, Diamond MP, Coutifaris C, Steiner AZ, Schlaff WD, Alvero R, Christman GM, Casson PR, Huang H, Santoro N, Eisenberg E, Zhang H, Cedars MI. Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 3288-3296. PMID: 27228369, PMCID: PMC5010565, DOI: 10.1210/jc.2016-1340.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAnti-Müllerian hormoneSerum anti-Müllerian hormoneAMH levelsOvulation inductionOvary syndromeHigh serum anti-Müllerian hormoneMean AMHSensitivity of folliclesHigher AMH levelsAntral follicle countBody mass indexRandomized clinical trialsOvulation induction medicationsWomen ages 18II trialFollicle countMass indexInduction medicationsInsulin levelsClinical trialsOvulatory responseHealth centersAromatase activityFSH stimulation
2013
Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS)
Wolff EF, He Y, Black DM, Brinton EA, Budoff MJ, Cedars MI, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Pal L, Santoro N, Zhang H, Harman SM, Taylor HS. Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS). Fertility And Sterility 2013, 99: 1385-1391. PMID: 23312232, PMCID: PMC3615128, DOI: 10.1016/j.fertnstert.2012.11.053.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarotid Artery DiseasesCarotid Intima-Media ThicknessCohort StudiesCoronary Artery DiseaseDisease ProgressionDyspareuniaEstrogen Replacement TherapyEstrogensFemaleFollow-Up StudiesHot FlashesHumansLongitudinal StudiesMenopauseMiddle AgedMood DisordersPredictive Value of TestsSelf ReportConceptsKronos Early Estrogen Prevention StudyCarotid intima-media thicknessSelf-reported menopausal symptomsIntima-media thicknessMenopausal symptomsMenopausal womenSubclinical atherosclerosisVaginal drynessPrevention StudyEarly menopausal womenElevated CAC scorePredictors of CACCoronary artery calcificationMeasures of atherosclerosisSerum E2 levelsSymptoms of insomniaSelf-reported symptomsCross-sectional analysisLogistic regression modelsMenopause onsetArtery calcificationCAC scoreNight sweatsPersistent symptomsClimacteric symptoms
2006
A Randomized Controlled Trial of a Coping Group Intervention for Adults With HIV Who Are AIDS Bereaved: Longitudinal Effects on Grief
Sikkema KJ, Hansen NB, Ghebremichael M, Kochman A, Tarakeshwar N, Meade CS, Zhang H. A Randomized Controlled Trial of a Coping Group Intervention for Adults With HIV Who Are AIDS Bereaved: Longitudinal Effects on Grief. Health Psychology 2006, 25: 563-570. PMID: 17014273, DOI: 10.1037/0278-6133.25.5.563.Peer-Reviewed Original ResearchConceptsGroup interventionPsychiatric distressCognitive-behavioral group interventionLongitudinal effectsIndividual therapy conditionComplicated grief responsesGlobal psychiatric distressAIDS bereavementReaction IndexTherapy conditionsDistressed peopleDiverse sampleGrief severityIndividual therapyDistressGrief responsesHIV/AIDSLongitudinal dataLong-term effectivenessParticipantsGriefControlled TrialsSeverity scoreInterventionStudy periodAdulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age
2003
Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study
Merikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J. Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study. JAMA Psychiatry 2003, 60: 993-1000. PMID: 14557144, DOI: 10.1001/archpsyc.60.9.993.Peer-Reviewed Original ResearchConceptsComorbid anxietyDiagnostic thresholdZurich cohort studyLong-term followCommunity-based cohortMajor mental disordersProspective community studyCommunity-based sampleCohort studyProspective studyComorbid statesAffective disordersMental disordersDiagnostic InterviewMid adulthoodCanton of ZurichCommunity studyAnxiety statesSubthreshold levelsAssessment pointsDepressionDisordersLongitudinal trajectoriesTreatment researchAnxietyRecurrence of bipolar disorders and major depression
Angst J, Gamma A, Sellaro R, Lavori PW, Zhang H. Recurrence of bipolar disorders and major depression. European Archives Of Psychiatry And Clinical Neuroscience 2003, 253: 236-240. PMID: 14504992, DOI: 10.1007/s00406-003-0437-2.Peer-Reviewed Original ResearchConceptsRecurrence riskBipolar disorderDepressive disorderMajor depressionLifelong prophylactic treatmentRisk of recurrenceState of remissionMajor depressive disorderHigh recurrence riskLong-term trialsProphylactic treatmentDepressive patientsNew episodesBipolar IIRecurrenceSevere typeBP-IIDisordersSignificant gender differencesDepressionRiskGender differencesConstant riskHospitalisationRemissionDevelopment of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders
2002
A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children
Peterson BS, Vohr B, Kane MJ, Whalen DH, Schneider KC, Katz KH, Zhang H, Duncan CC, Makuch R, Gore JC, Ment LR. A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children. Pediatrics 2002, 110: 1153-1162. PMID: 12456913, DOI: 10.1542/peds.110.6.1153.Peer-Reviewed Original ResearchConceptsLanguage comprehension taskFunctional magnetic resonance imagingBrain activityLanguage comprehensionComprehension taskPreterm childrenIQ scoresFunctional magnetic resonance imaging studyLower verbal IQ scoresProcessing tasksSemantic processing taskAbnormal neural processingVerbal IQ scoresPoor language comprehensionCommunity control childrenMagnetic resonance imaging studyCognitive correlatesResonance imaging studySemantic processingNeural processingScanning taskFMRI scansLanguage processingControl childrenBrain structuresToward validation of atypical depression in the community: results of the Zurich cohort study
Angst J, Gamma A, Sellaro R, Zhang H, Merikangas K. Toward validation of atypical depression in the community: results of the Zurich cohort study. Journal Of Affective Disorders 2002, 72: 125-138. PMID: 12200203, DOI: 10.1016/s0165-0327(02)00169-6.Peer-Reviewed Original ResearchConceptsZurich cohort studyAtypical depressionCohort studyAtypical subtypeAtypical major depressive episodeCommunity-based longitudinal cohort studyDSM-IV atypical depressionAtypical depressive subtypesSignificant female preponderanceSex differencesAtypical depressive symptomsPopulation-based cohortMajor depressive episodeLongitudinal cohort studyHigh population prevalenceMood reactivitySymptom Checklist-90Marked sex differenceFemale preponderanceTreatment patternsAtypical syndromesClinical correlatesDepressive episodeDepressive subtypesClinical severity
1998
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. Pediatrics 1998, 102: 14-19. PMID: 9651407, DOI: 10.1542/peds.102.1.14.Peer-Reviewed Original ResearchConceptsYears of ageTic severityTS patientsTourette syndromeSeverity of ticsInitial clinical evaluationDecades of lifeConsistent time courseOnset of pubertyPatient's coursePrognostic valueTic onsetYale Child Study CenterClinical evaluationBirth-year cohortsPrevalence studyPatientsSeverityStudy centersChild Study CenterIdentification of factorsSevere levelsAgeProgressive patternSyndrome