2018
Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction
Li J, Wu Q, Wu XK, Zhou ZM, Fu P, Chen XH, Yan Y, Wang X, Yang ZW, Li WL, Stener-Victorin E, Legro RS, Ng EH, Zhang H, Mol BWJ, Wang CC, Group F. Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction. Human Reproduction 2018, 33: 617-625. PMID: 29471520, DOI: 10.1093/humrep/dey027.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeNon-exposed womenSHS exposure statusSHS exposureMetabolic syndromeBiochemical hyperandrogenismObstetric outcomesOvary syndromeOvulation inductionSex hormonesExposure statusHigher serum total testosteroneSecond-hand smoke exposureSTUDY FUNDING/COMPETINGConception rateLower sex hormoneFree androgen indexSerum total testosteroneUterine blood flowLive birth rateNon-exposed groupSecond-hand smokePARTICIPANTS/MATERIALSROLE OF CHANCEAndrogen index
2017
Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome
Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro RS, Zhang H, Chen ZJ. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 3822-3829. PMID: 28938429, DOI: 10.1210/jc.2017-01294.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testPolycystic ovary syndromePregnancy outcomesI-IFGOvary syndromeGlucose toleranceHigh riskIntrinsic insulin resistanceAdverse pregnancy outcomesTotal testosterone levelsDuration of infertilityImpaired glucose tolerancePregnancy loss rateBody mass indexFrozen embryo transferGlucose tolerance testMain outcome measuresGestational diabetesObstetric complicationsSingleton newbornsSingleton pregnanciesGestational ageMass indexTwin pregnanciesInsulin levels
2015
Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome
Kuang H, Jin S, Hansen KR, Diamond MP, Coutifaris C, Casson P, Christman G, Alvero R, Huang H, Bates GW, Usadi R, Lucidi S, Baker V, Santoro N, Eisenberg E, Legro RS, Zhang H, Network F, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Easton C, Hernandez A, Leija M, Pierce D, Bryzski R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Schlaff W, Comfort A, Crow M, Hohmann A, Mallette S, Ringbloom M, Tang J, Mason S, DiMaria N, Rhea M, Turner K, Haisenleder D, Trussell J, DelBasso D, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Zhang M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome. Human Reproduction 2015, 30: 2222-2233. PMID: 26202922, PMCID: PMC4542721, DOI: 10.1093/humrep/dev182.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromePregnancy outcomesInfertile womenClomiphene citrateOvary syndromeChi-square testLogistic regression modelsLive birthsBaseline sex hormone-binding globulinPolycystic Ovary Syndrome ISecondary analysisEunice Kennedy Shriver National InstituteSex hormone-binding globulinSevere PCOS phenotypeFree androgen indexRole of smokingKey baseline characteristicsHormone-binding globulinSignificant risk factorsPARTICIPANTS/MATERIALSSignificant predictorsROLE OF CHANCEPredictors of ovulationGrant supportNIH grant support
2012
Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome
Diamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 902-908. PMID: 22525900, PMCID: PMC4007263, DOI: 10.1097/aog.0b013e31824da35c.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birth rateAnovulatory cyclesEndometrial sheddingClomiphene citrateOvary syndromeLive birthsEunice Kennedy Shriver National InstituteBirth rateCommon clinical practiceOccurrence of ovulationRate of conceptionAnovulatory womenOvarian stimulationOvulation inductionSpontaneous mensesProgestin withdrawalChild healthClinical practiceNetwork trialSecondary analysisOvulation rateMetforminAdverse effectsWomen