2019
Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth
Parry S, Leite R, Esplin MS, Bukowski R, Zhang H, Varner M, Andrews WW, Saade GR, Ilekis J, Reddy UM, Huang H, Sadovsky Y, Blair IA, Biggio J, Research E. Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth. American Journal Of Obstetrics And Gynecology 2019, 222: 493.e1-493.e13. PMID: 31758918, PMCID: PMC7196033, DOI: 10.1016/j.ajog.2019.11.1252.Peer-Reviewed Original ResearchConceptsPreterm birth casesSpontaneous preterm birthCervicovaginal fluid samplesEnzyme-linked immunosorbentTerm delivery controlsPreterm birthStudy visitBirth casesFluid samplesPotential biomarkersSpontaneous preterm birth ratePrior spontaneous preterm birthEarly spontaneous preterm birthCervical length screeningThird study visitVaginal mucosal cellsPreterm birth rateHigh-risk cohortCase-control studyReliable screening testAvailable biological fluidIndependent study groupsNeonatal morbidityObstetrical historyAsymptomatic womenAssociations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index
Rios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG. Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz012. PMID: 31586179, PMCID: PMC7024739, DOI: 10.1210/clinem/dgz012.Peer-Reviewed Original ResearchConceptsHomeostasis model assessment-insulin resistancePolycystic ovary syndromeAnti-Mullerian hormoneBody mass indexC-reactive proteinUnexplained infertilityWaist circumferenceOVA groupLipoprotein cholesterolMass indexRelationship of AMHModel assessment-insulin resistanceHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolSite-adjusted modelsAssessment-insulin resistanceAntral follicle countCardio-metabolic healthReproductive-aged womenMultivariable linear regression modelsReproductive-age womenClinical populationsLow-density lipoproteinCardiometabolic agingCardiometabolic indices
2018
Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory
Cherskov A, Pohl A, Allison C, Zhang H, Payne RA, Baron-Cohen S. Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory. Translational Psychiatry 2018, 8: 136. PMID: 30065244, PMCID: PMC6068102, DOI: 10.1038/s41398-018-0186-7.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical Practice Research DatalinkOvary syndromeOdds ratioPrevalence of PCOSRisk of PCOSMaternal metabolic conditionsMaternal psychiatric diagnosisChildren of womenCase-control studyPrenatal testosteroneRisk of autismElectronic health recordsObstetric complicationsSex steroidsPsychiatric diagnosisGreater riskMetabolic conditionsElevated levelsHealth recordsWomenSyndromeChildrenRiskTestosteroneGestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study
Kent J, Dodson WC, Kunselman A, Pauli J, Stone A, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Hansen KR, Robinson R, Baker V, Usadi R, Santoro N, Zhang H, Eisenberg E, Legro RS, Network R. Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4315-4323. PMID: 30085187, PMCID: PMC6194806, DOI: 10.1210/jc.2017-02764.Peer-Reviewed Original ResearchConceptsPreconception body mass indexGestational weight gainPolycystic ovary syndromeBody mass indexOvulatory controlsPregnancy complicationsOvary syndromeObese groupWeight gainSecond trimesterExcessive gestational weight gainPre-existing obesityProspective cohort studyNormal-weight womenContribution of diagnosisPreconception baselinePreconception weightGestational diabetesPerinatal outcomesCohort studyPerinatal complicationsSingleton pregnanciesMass indexNormal weightFirst trimester
2015
Soluble levels of CD27 and CD30 are associated with risk of non‐Hodgkin lymphoma in three Chinese prospective cohorts
Bassig BA, Shu XO, Koh WP, Gao YT, Purdue MP, Butler LM, Adams-Haduch J, Xiang YB, Kemp TJ, Wang R, Pinto LA, Zheng T, Ji BT, Hosgood HD, Hu W, Yang G, Zhang H, Chow WH, Kim C, Seow WJ, Zheng W, Yuan JM, Lan Q, Rothman N. Soluble levels of CD27 and CD30 are associated with risk of non‐Hodgkin lymphoma in three Chinese prospective cohorts. International Journal Of Cancer 2015, 137: 2688-2695. PMID: 26095604, PMCID: PMC4898881, DOI: 10.1002/ijc.29637.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaB cell activationProspective studyNHL riskWestern populationsChinese prospective cohortIntermediate endpoint biomarkersCase-control studySoluble CD30Prospective cohortSoluble CD27Fourth quartileBlood drawLowest quartileEndpoint biomarkersNHL casesImportant underlying mechanismChinese menSimilar associationSoluble levelsSCD27SCD30CD30CD27Underlying mechanismCluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotypeThe phenotype of spontaneous preterm birth: application of a clinical phenotyping tool
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleGestational AgeHumansPhenotypePregnancyPremature BirthProspective StudiesRisk FactorsUnited StatesConceptsSpontaneous preterm birthEarly spontaneous preterm birthInfection/inflammationDecidual hemorrhageGestational ageCervical insufficiencyPreterm birthWeeks' gestationPlacental dysfunctionWhite womenMaternal stressSingleton spontaneous preterm birthDelivery gestational ageFinal common pathwayAfrican American womenMaternal comorbiditiesPremature ruptureProspective studyPlanned analysisUterine distentionClinical dataMultiple possible causesGestationHemorrhageComprehensive classification systemA Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sitesMaternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates
Shankaran S, Lin A, Maller-Kesselman J, Zhang H, O'Shea TM, Bada HS, Kaiser JR, Lifton RP, Bauer CR, Ment LR, Study G. Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates. The Journal Of Pediatrics 2014, 164: 1005-1011.e3. PMID: 24589078, PMCID: PMC4095864, DOI: 10.1016/j.jpeds.2014.01.036.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBlack PeopleCase-Control StudiesCerebral HemorrhageFemaleHealthcare DisparitiesHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLogistic ModelsMaleMultivariate AnalysisPregnancyPrenatal CareRisk FactorsSocioeconomic FactorsSwedenUltrasonographyUnited StatesWhite PeopleConceptsIntraventricular hemorrhageWhite infantsGrade 2Multiple gestationsPrenatal visitWhite raceNeonatal intensive care unitAntenatal steroid exposureGestational age infantsBirth weight 500Birth weight rangeIntensive care unitAfrican ancestryMultivariate logistic regressionHigher maternal educationHigh-frequency ventilationHealth care disparitiesAntenatal steroidsApgar scoreCesarean deliveryPreterm neonatesCare unitGestational ageSteroid exposureAge infants
2013
Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence
Zuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X. Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence. American Journal On Addictions 2013, 23: 411-414. PMID: 24961364, PMCID: PMC4111256, DOI: 10.1111/j.1521-0391.2013.12115.x.Peer-Reviewed Original ResearchRare SERINC2 variants are specific for alcohol dependence in individuals of European descent
Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.Peer-Reviewed Original ResearchCandidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates
Ådén U, Lin A, Carlo W, Leviton A, Murray JC, Hallman M, Lifton RP, Zhang H, Ment LR, Group G. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates. The Journal Of Pediatrics 2013, 163: 1503-1506.e1. PMID: 23896193, PMCID: PMC3812267, DOI: 10.1016/j.jpeds.2013.06.025.Peer-Reviewed Original ResearchNKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesExpression quantitative loci (eQTL) analysisGene regionMetabolic pathwaysQuantitative loci analysisSNP-expression associationsCis-acting regulatory effectsDiscovery sampleSNP-disease associationsNumerous genesReplication sampleLocus analysisAssociation studiesAssociation analysisRisk SNPsTranscript expressionSNPsRegulatory effectsGenesPathwayEuropean descentExpression
2012
Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence
Zuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBeta KaryopherinsBlack or African AmericanCase-Control StudiesChromosomes, Human, Pair 5FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ATobacco Use DisorderWhite PeopleConceptsGenome-wide significance levelSingle nucleotide polymorphismsReplication cohortDiscovery cohortAlcohol dependenceExpression quantitative loci (eQTL) analysisPeripheral blood mononuclear cell samplesNeuropsychiatric disordersWide significant association signalsMononuclear cell samplesGenome-wide association studiesQuantitative loci analysisGene-disease association analysisCis-eQTL analysisTop single nucleotide polymorphismsCis-acting regulatory effectsSignificant association signalsBrain tissue samplesAmerican controlsEuropean American controlsRisk single nucleotide polymorphismsAfrican-American controlsSevere subtypeGenomic regionsAfrican American cases
2011
The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin Women
Chen X, Cho K, Singer BH, Zhang H. The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin Women. PLOS ONE 2011, 6: e16002. PMID: 21298047, PMCID: PMC3029286, DOI: 10.1371/journal.pone.0016002.Peer-Reviewed Original Research
2007
Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools
Zhu Y, Hoffman A, Wu X, Zhang H, Zhang Y, Leaderer D, Zheng T. Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2007, 639: 80-88. PMID: 18191955, PMCID: PMC2292456, DOI: 10.1016/j.mrfmmm.2007.11.005.Peer-Reviewed Original Research
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process
2003
Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment
SUKHODOLSKY DG, SCAHILL L, ZHANG H, PETERSON BS, KING RA, LOMBROSO PJ, KATSOVICH L, FINDLEY D, LECKMAN JF. Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 98-105. PMID: 12500082, DOI: 10.1097/00004583-200301000-00016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComorbid attention-deficit/hyperactivity disorderDisruptive behaviorFamily functioningParent ratingsTeacher ratingsDiagnosis of ADHDVineland Adaptive Behavior ScalesDisruptive behavior problemsHierarchical regression analysisAdaptive Behavior ScalesBest-estimate DSM-IV diagnosesUnaffected control childrenTourette syndromeConduct problemsDelinquency scoresHyperactivity disorderADHD comorbidityDelinquent behaviorBehavior problemsDSM-IV diagnosisDependent measuresDiagnostic statusBehavior ScaleFunctional impairment
1999
Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children
SCAHILL L, SCHWAB-STONE M, MERIKANGAS K, LECKMAN J, ZHANG H, KASL S. Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 976-984. PMID: 10434489, DOI: 10.1097/00004583-199908000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD groupCommunity sampleFamily dysfunctionSubthreshold attention-deficit hyperactivity disorderGlobal Assessment ScaleDisruptive behavior disordersChildren's Global Assessment ScaleStructured diagnostic interviewPsychiatric comorbiditySchool-aged childrenADHD statusHyperactivity disorderPsychosocial adversityExcessive alcohol useDimensional approachDiagnostic InterviewLow-income familiesAlcohol useBehavior disorderClinical correlatesSubthreshold groupChildrenAssessment ScalePsychiatric treatment