2019
Common genetic variants have associations with human cortical brain regions and risk of schizophrenia
Bi X, Feng L, Wang S, Lin Z, Li T, Zhao B, Zhu H, Zhang H. Common genetic variants have associations with human cortical brain regions and risk of schizophrenia. Genetic Epidemiology 2019, 43: 548-558. PMID: 30941828, PMCID: PMC6559856, DOI: 10.1002/gepi.22203.Peer-Reviewed Original ResearchConceptsCortical regionsCortical brain regionsRisk of schizophreniaPrefrontal cortical regionsSymptom durationProdromal symptomsMental disordersSignificant associationBrain regionsCommon genetic variantsPhiladelphia Neurodevelopmental CohortPediatric imagingSchizophreniaNeurodevelopmental CohortCommon variantsHuman brainGenetic variantsHeritable mental disorderMagnetic resonanceAssociationWide association studyAssociation studiesGenetic effectsCohortSymptoms
2018
Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory
Cherskov A, Pohl A, Allison C, Zhang H, Payne RA, Baron-Cohen S. Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory. Translational Psychiatry 2018, 8: 136. PMID: 30065244, PMCID: PMC6068102, DOI: 10.1038/s41398-018-0186-7.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical Practice Research DatalinkOvary syndromeOdds ratioPrevalence of PCOSRisk of PCOSMaternal metabolic conditionsMaternal psychiatric diagnosisChildren of womenCase-control studyPrenatal testosteroneRisk of autismElectronic health recordsObstetric complicationsSex steroidsPsychiatric diagnosisGreater riskMetabolic conditionsElevated levelsHealth recordsWomenSyndromeChildrenRiskTestosterone
2015
Predictors of participant retention in infertility treatment trials
Kuang H, Jin S, Thomas T, Engmann L, Hansen KR, Coutifaris C, Casson P, Christman G, Alvero R, Santoro N, Eisenberg E, Diamond MP, Legro RS, Zhang H, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Easton C, Hernandez A, Leija M, Pierce D, Bryzski R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Schlaff W, Comfort A, Crow M, Hohmann A, Mallette S, Ringbloom M, Tang J, Mason S, DiMaria N, Rhea M, Turner K, Haisenleder D, Trussell J, DelBasso D, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Zhang M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Predictors of participant retention in infertility treatment trials. Fertility And Sterility 2015, 104: 1236-1243.e2. PMID: 26354094, PMCID: PMC4630082, DOI: 10.1016/j.fertnstert.2015.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultChi-Square DistributionDrug Therapy, CombinationFemaleFertilityFertility Agents, FemaleHumansInfertility, FemaleLogistic ModelsMaleMultivariate AnalysisOdds RatioPatient DropoutsPatient SelectionPolycystic Ovary SyndromePregnancyRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeYoung AdultConceptsPolycystic ovary syndromeBody mass indexClomiphene citrateClinical trialsHistory of smokingInsurance coverageCombination of metforminMultivariable logistic modelAcademic medical centerRetention of subjectsConduct of RCTsBetter insurance coverageUnexplained infertilityOvary syndromeNormal weightMass indexOriginal RCTTreatment trialsMedical CenterMAIN OUTCOMEWhite raceIntervention studiesRCTsSecondary analysisParticipant retentionCluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotype
2014
Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates
Shankaran S, Lin A, Maller-Kesselman J, Zhang H, O'Shea TM, Bada HS, Kaiser JR, Lifton RP, Bauer CR, Ment LR, Study G. Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates. The Journal Of Pediatrics 2014, 164: 1005-1011.e3. PMID: 24589078, PMCID: PMC4095864, DOI: 10.1016/j.jpeds.2014.01.036.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBlack PeopleCase-Control StudiesCerebral HemorrhageFemaleHealthcare DisparitiesHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLogistic ModelsMaleMultivariate AnalysisPregnancyPrenatal CareRisk FactorsSocioeconomic FactorsSwedenUltrasonographyUnited StatesWhite PeopleConceptsIntraventricular hemorrhageWhite infantsGrade 2Multiple gestationsPrenatal visitWhite raceNeonatal intensive care unitAntenatal steroid exposureGestational age infantsBirth weight 500Birth weight rangeIntensive care unitAfrican ancestryMultivariate logistic regressionHigher maternal educationHigh-frequency ventilationHealth care disparitiesAntenatal steroidsApgar scoreCesarean deliveryPreterm neonatesCare unitGestational ageSteroid exposureAge infants
2012
Simulating Realistic Genomic Data With Rare Variants
Xu Y, Wu Y, Song C, Zhang H. Simulating Realistic Genomic Data With Rare Variants. Genetic Epidemiology 2012, 37: 163-172. PMID: 23161487, PMCID: PMC3543480, DOI: 10.1002/gepi.21696.Peer-Reviewed Original ResearchPredictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility
Huang H, Hansen KR, Factor-Litvak P, Carson SA, Guzick DS, Santoro N, Diamond MP, Eisenberg E, Zhang H, Network I. Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility. Fertility And Sterility 2012, 97: 959-967.e5. PMID: 22270557, PMCID: PMC3319287, DOI: 10.1016/j.fertnstert.2012.01.090.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAlcohol DrinkingAlcoholic BeveragesChi-Square DistributionCoffeeFemaleHumansInfertilityInfertility, MaleInsemination, ArtificialLife StyleLive BirthLogistic ModelsMaleMiddle AgedMultivariate AnalysisOvulation InductionPregnancyPregnancy RateProspective StudiesRisk AssessmentRisk FactorsRisk Reduction BehaviorSuperovulationSurveys and QuestionnairesTeaTreatment OutcomeUnited StatesYoung AdultConceptsLive birth rateMale factor infertilityLive birthsPregnancy outcomesHigher pregnancyBirth ratePredictors of pregnancyAlcoholic beveragesFemale partnersOccurrence of pregnancyAcademic medical centerLifestyle factorsIntrauterine inseminationRisk factorsLifestyle questionnaireOccupational exposureMedical CenterLifestyle changesMAIN OUTCOMETreatment groupsPregnancySecondary analysisPast usersCurrent usersBirth
2010
The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis
Bizzarro MJ, Jiang Y, Hussain N, Gruen JR, Bhandari V, Zhang H. The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis. The Journal Of Pediatrics 2010, 158: 234-238.e1. PMID: 20850766, PMCID: PMC3008342, DOI: 10.1016/j.jpeds.2010.07.060.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetBirth WeightBlood-Borne PathogensCohort StudiesConfidence IntervalsCross InfectionEnvironmental ExposureFemaleGenetic Predisposition to DiseaseHospital MortalityHumansInfant, NewbornIntensive Care Units, NeonatalLogistic ModelsMalePrognosisRetrospective StudiesSepsisSurvival RateTime FactorsTwinsTwins, DizygoticTwins, MonozygoticConceptsLate-onset sepsisNewborn intensive care unitIntensive care unitCare unitBirth weightIntensive care unit populationNeonatal late-onset sepsisRetrospective cohort analysisTotal parenteral nutritionRespiratory distress syndromeGenetic factorsLogistic regression analysisMixed-effects logistic regressionNongenetic factorsMixed-effects logistic regression analysisSignificant genetic susceptibilityDistress syndromeParenteral nutritionGestational ageCohort analysisSepsisUnit populationConcordance rateGenetic susceptibilityLogistic regression
2009
The Genetic Susceptibility to Respiratory Distress Syndrome
Levit O, Jiang Y, Bizzarro MJ, Hussain N, Buhimschi CS, Gruen JR, Zhang H, Bhandari V. The Genetic Susceptibility to Respiratory Distress Syndrome. Pediatric Research 2009, 66: 693-697. PMID: 19687775, PMCID: PMC2796284, DOI: 10.1203/pdr.0b013e3181bbce86.Peer-Reviewed Original Research
2006
Substance-abusing mothers and disruptions in child custody: An attachment perspective
Suchman NE, McMahon TJ, Zhang H, Mayes LC, Luthar S. Substance-abusing mothers and disruptions in child custody: An attachment perspective. Journal Of Substance Use And Addiction Treatment 2006, 30: 197-204. PMID: 16616163, PMCID: PMC1850760, DOI: 10.1016/j.jsat.2005.11.008.Peer-Reviewed Original ResearchConceptsAttachment perspectiveInternal psychological processesMothers' perceptionsParental Bonding InstrumentSubstance-abusing mothersPsychological maladjustmentPsychological processesMultilevel modeling approachAttachment frameworkAddiction Severity IndexSubstance abuseChild placementDemographic questionnaireChild custodyPerceptionComposite scoreMethadone maintenance programMaladjustmentParentingMothersAbuseParentsPerspectiveSeverity IndexChildrenRecursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery
Sedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAtrial fibrillationLow-risk groupAggressive prophylaxisRelative riskPredictors of AFArtery bypass graft surgeryCoronary artery bypass surgeryRisk of AFYale-New Haven HospitalOnly ejection fractionPreoperative atrial fibrillationBypass graft surgeryArtery bypass surgeryCoronary artery diseasePreoperative risk stratificationHigh-risk groupHeart disease severityPossible adverse eventsOlder age subgroupsArrhythmia prophylaxisGraft surgeryProphylactic therapyAdverse eventsBypass surgery
2001
Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey
Robbins JM, Vaccarino V, Zhang H, Kasl SV. Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. American Journal Of Public Health 2001, 91: 76-83. PMID: 11189829, PMCID: PMC1446485, DOI: 10.2105/ajph.91.1.76.Peer-Reviewed Original ResearchConceptsPoverty income ratioType 2 diabetes prevalenceNon-Hispanic white womenNutrition Examination SurveyThird National HealthDiabetes prevalenceRisk factorsAfrican American womenWhite womenExamination SurveyNational HealthSocioeconomic statusPrevalence of diabetesType 2 diabetesAmerican womenAfrican American menOccupational statusDiabetesSignificant associationPrevalenceWhite menCross-sectional dataWomenAmerican menMen
1999
Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children
SCAHILL L, SCHWAB-STONE M, MERIKANGAS K, LECKMAN J, ZHANG H, KASL S. Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 976-984. PMID: 10434489, DOI: 10.1097/00004583-199908000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD groupCommunity sampleFamily dysfunctionSubthreshold attention-deficit hyperactivity disorderGlobal Assessment ScaleDisruptive behavior disordersChildren's Global Assessment ScaleStructured diagnostic interviewPsychiatric comorbiditySchool-aged childrenADHD statusHyperactivity disorderPsychosocial adversityExcessive alcohol useDimensional approachDiagnostic InterviewLow-income familiesAlcohol useBehavior disorderClinical correlatesSubthreshold groupChildrenAssessment ScalePsychiatric treatment
1996
Tree-based, Two-stage Risk Factor Analysis for Spontaneous Abortion
Zhang H, Bracken M. Tree-based, Two-stage Risk Factor Analysis for Spontaneous Abortion. American Journal Of Epidemiology 1996, 144: 989-996. PMID: 8916510, DOI: 10.1093/oxfordjournals.aje.a008869.Peer-Reviewed Original ResearchConceptsSpontaneous abortionPutative risk factorsRisk factorsPotential confoundersFirst monthYears of smokingNegative pregnancy outcomesNumber of pregnanciesRisk factor analysisNew risk factorsPotential confounding factorsPregnancy outcomesGynecologic problemsMaternal ageMore cupsMother's heightPregnancyConfounding factorsPassive exposureCocaine useLogistic regressionMantel-HaenszelAbortionConfoundersBirth control