2003
Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study
Merikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J. Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study. JAMA Psychiatry 2003, 60: 993-1000. PMID: 14557144, DOI: 10.1001/archpsyc.60.9.993.Peer-Reviewed Original ResearchConceptsComorbid anxietyDiagnostic thresholdZurich cohort studyLong-term followCommunity-based cohortMajor mental disordersProspective community studyCommunity-based sampleCohort studyProspective studyComorbid statesAffective disordersMental disordersDiagnostic InterviewMid adulthoodCanton of ZurichCommunity studyAnxiety statesSubthreshold levelsAssessment pointsDepressionDisordersLongitudinal trajectoriesTreatment researchAnxietyRecurrence of bipolar disorders and major depression
Angst J, Gamma A, Sellaro R, Lavori PW, Zhang H. Recurrence of bipolar disorders and major depression. European Archives Of Psychiatry And Clinical Neuroscience 2003, 253: 236-240. PMID: 14504992, DOI: 10.1007/s00406-003-0437-2.Peer-Reviewed Original ResearchConceptsRecurrence riskBipolar disorderDepressive disorderMajor depressionLifelong prophylactic treatmentRisk of recurrenceState of remissionMajor depressive disorderHigh recurrence riskLong-term trialsProphylactic treatmentDepressive patientsNew episodesBipolar IIRecurrenceSevere typeBP-IIDisordersSignificant gender differencesDepressionRiskGender differencesConstant riskHospitalisationRemissionBasal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGangliaDisruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment
SUKHODOLSKY DG, SCAHILL L, ZHANG H, PETERSON BS, KING RA, LOMBROSO PJ, KATSOVICH L, FINDLEY D, LECKMAN JF. Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 98-105. PMID: 12500082, DOI: 10.1097/00004583-200301000-00016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComorbid attention-deficit/hyperactivity disorderDisruptive behaviorFamily functioningParent ratingsTeacher ratingsDiagnosis of ADHDVineland Adaptive Behavior ScalesDisruptive behavior problemsHierarchical regression analysisAdaptive Behavior ScalesBest-estimate DSM-IV diagnosesUnaffected control childrenTourette syndromeConduct problemsDelinquency scoresHyperactivity disorderADHD comorbidityDelinquent behaviorBehavior problemsDSM-IV diagnosisDependent measuresDiagnostic statusBehavior ScaleFunctional impairment
2002
The spectrum of social phobia in the zurich cohort study of young adults
Merikangas KR, Avenevoli S, Acharyya S, Zhang H, Angst J. The spectrum of social phobia in the zurich cohort study of young adults. Biological Psychiatry 2002, 51: 81-91. PMID: 11801233, DOI: 10.1016/s0006-3223(01)01309-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetCatchment Area, HealthCognitive Behavioral TherapyCohort StudiesComorbidityCuesFemaleHumansInterpersonal RelationsMalePersonalityPhobic DisordersPrevalencePsychiatric Status Rating ScalesSeverity of Illness IndexSocial PerceptionSubstance-Related DisordersSwitzerlandTemperamentConceptsDiagnostic thresholdProspective-longitudinal community studySocial phobiaYoung adultsZurich cohort studyHigher lifetime ratesLongitudinal community studyPercent of participantsSocial phobia symptomsCohort studyMedication useStudy entryWork impairmentClinical indicatorsRisk factorsUndiagnosed casesFamily historyEqual gender ratioAge 35Phobia symptomsGeneral populationLifetime ratesLongitudinal courseTreatment ratesCommunity study
2000
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Peterson BS, Leckman JF, Tucker D, Scahill L, Staib L, Zhang H, King R, Cohen DJ, Gore JC, Lombroso P. Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders. JAMA Psychiatry 2000, 57: 364-372. PMID: 10768698, DOI: 10.1001/archpsyc.57.4.364.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesAttention-deficit/hyperactivity disorderAntistreptococcal antibody titersObsessive-compulsive disorderAntibody titersGanglia volumesStreptococcal infectionAntistreptococcal antibodiesPreliminary serological evidencePrior streptococcal infectionRecurrent streptococcal infectionsHyperactivity disorderPresence of ADHDBasal ganglia nucleiHigh antibody titersGlobus pallidus nucleusDSM-IV diagnosisStreptococcal exposurePallidus nucleusAntistreptolysin OOCD comorbiditySerological evidenceSusceptible personsTic disordersDiagnostic comorbidity
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsion