2019
Common genetic variants have associations with human cortical brain regions and risk of schizophrenia
Bi X, Feng L, Wang S, Lin Z, Li T, Zhao B, Zhu H, Zhang H. Common genetic variants have associations with human cortical brain regions and risk of schizophrenia. Genetic Epidemiology 2019, 43: 548-558. PMID: 30941828, PMCID: PMC6559856, DOI: 10.1002/gepi.22203.Peer-Reviewed Original ResearchConceptsCortical regionsCortical brain regionsRisk of schizophreniaPrefrontal cortical regionsSymptom durationProdromal symptomsMental disordersSignificant associationBrain regionsCommon genetic variantsPhiladelphia Neurodevelopmental CohortPediatric imagingSchizophreniaNeurodevelopmental CohortCommon variantsHuman brainGenetic variantsHeritable mental disorderMagnetic resonanceAssociationWide association studyAssociation studiesGenetic effectsCohortSymptoms
2018
Major depression, antidepressant use, and male and female fertility
Evans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, Casson PR, Christman GM, Hansen KR, Zhang H, Santoro N, Steiner AZ, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Ager J, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Lecks K, Martino L, Marunich R, Comfort A, Crow M, Hohmann A, Mallette S, Smith Y, Randolph J, Fisseha S, Ohl D, Ringbloom M, Tang J, Bates W, Mason S, Craig L, Zornes C, Rodriguez M, Hunt T, DiMaria N, Usadi R, Lucidi S, Rhea M, Baker V, Turner K, Brennan M, DelBasso D, Huang H, Jin Y, Li Y, Kuang H, Makuch R, Patrizio P, Sakai L, Scahill L, Song C, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Trussell J, Laylor B, Martinez L, Solnica A, Wojtczuk A, Seungdamrong A, Rosen M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Major depression, antidepressant use, and male and female fertility. Fertility And Sterility 2018, 109: 879-887. PMID: 29778387, PMCID: PMC5973807, DOI: 10.1016/j.fertnstert.2018.01.029.Peer-Reviewed Original ResearchConceptsMaternal major depressionMaternal antidepressant useAntidepressant useLikelihood of pregnancyMale partnersMajor depressionNon-IVF fertility treatmentsFirst trimester pregnancy lossTypes of antidepressantsPHQ-9 scoresFirst trimester miscarriagePatient Health QuestionnairePoor fertility outcomesRisk of miscarriagePoisson regression modelsPPCOS IICohort studyPregnancy outcomesMedication usePrimary outcomeRandomized trialsPregnancy lossHealth QuestionnaireRelative riskTreatment outcomesWhole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort
Wen C, Mehta CM, Tan H, Zhang H. Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort. Genetic Epidemiology 2018, 42: 265-275. PMID: 29411414, PMCID: PMC5851842, DOI: 10.1002/gepi.22111.Peer-Reviewed Original ResearchConceptsGenetic markersGenome-wide association study datasetWhole-genome association studiesComplex genetic basisGenome association studiesBrain-wide imaging phenotypesMultivariate phenotypesGenetic basisAssociation studiesGenetic studiesNeuropsychological disordersClinical diagnostic criteriaCovariance testBiological basisPhenotypeDiagnostic criteriaNeuroimaging biomarkersBrain functionBrain structuresPediatric imagingGWASImaging phenotypesDiffusion tensor
2017
Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes
Bi X, Yang L, Li T, Wang B, Zhu H, Zhang H. Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes. Human Brain Mapping 2017, 38: 4088-4097. PMID: 28544218, PMCID: PMC5568842, DOI: 10.1002/hbm.23650.Peer-Reviewed Original Research
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sites
2013
Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism
Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X. Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics 2013, 132: 735-743. PMID: 23468174, PMCID: PMC3683370, DOI: 10.1007/s00439-013-1277-4.Peer-Reviewed Original ResearchSelf-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS)
Wolff EF, He Y, Black DM, Brinton EA, Budoff MJ, Cedars MI, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Pal L, Santoro N, Zhang H, Harman SM, Taylor HS. Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS). Fertility And Sterility 2013, 99: 1385-1391. PMID: 23312232, PMCID: PMC3615128, DOI: 10.1016/j.fertnstert.2012.11.053.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarotid Artery DiseasesCarotid Intima-Media ThicknessCohort StudiesCoronary Artery DiseaseDisease ProgressionDyspareuniaEstrogen Replacement TherapyEstrogensFemaleFollow-Up StudiesHot FlashesHumansLongitudinal StudiesMenopauseMiddle AgedMood DisordersPredictive Value of TestsSelf ReportConceptsKronos Early Estrogen Prevention StudyCarotid intima-media thicknessSelf-reported menopausal symptomsIntima-media thicknessMenopausal symptomsMenopausal womenSubclinical atherosclerosisVaginal drynessPrevention StudyEarly menopausal womenElevated CAC scorePredictors of CACCoronary artery calcificationMeasures of atherosclerosisSerum E2 levelsSymptoms of insomniaSelf-reported symptomsCross-sectional analysisLogistic regression modelsMenopause onsetArtery calcificationCAC scoreNight sweatsPersistent symptomsClimacteric symptoms
2012
Prenatal Exposure to Nicotine and Impaired Reading Performance
Cho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal Exposure to Nicotine and Impaired Reading Performance. The Journal Of Pediatrics 2012, 162: 713-718.e2. PMID: 23122624, PMCID: PMC3577994, DOI: 10.1016/j.jpeds.2012.09.041.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPrenatal nicotine exposureSkill outcomesAge childrenLongitudinal studyPotential mediatorsNicotine exposureSkills of childrenPhonological deficitPrenatal exposureRisk of underperformanceReading performanceSingle wordsAvon Longitudinal StudyLongitudinal samplePoor performanceLarge associationsNegative associationChildrenAreas of speedParentsSpellingFluencyNicotineComprehensionRare ADH Variant Constellations are Specific for Alcohol Dependence
Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.Peer-Reviewed Original Research
2011
Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder
Jiang Y, Zhang H. Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder. Genetic Epidemiology 2011, 35: 125-132. PMID: 21254220, PMCID: PMC3077545, DOI: 10.1002/gepi.20558.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsGenetic variantsWellcome Trust Case Control ConsortiumRPGRIP1L geneGenetic studiesAssociation analysisHaplotype blocksChromosome 16Nucleotide polymorphismsComplex diseasesGenesComplex disorderStrong signalUnreported regionsVariantsImportant roleStrong evidencePolymorphismBipolar disorderRegion
2010
The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis
Bizzarro MJ, Jiang Y, Hussain N, Gruen JR, Bhandari V, Zhang H. The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis. The Journal Of Pediatrics 2010, 158: 234-238.e1. PMID: 20850766, PMCID: PMC3008342, DOI: 10.1016/j.jpeds.2010.07.060.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetBirth WeightBlood-Borne PathogensCohort StudiesConfidence IntervalsCross InfectionEnvironmental ExposureFemaleGenetic Predisposition to DiseaseHospital MortalityHumansInfant, NewbornIntensive Care Units, NeonatalLogistic ModelsMalePrognosisRetrospective StudiesSepsisSurvival RateTime FactorsTwinsTwins, DizygoticTwins, MonozygoticConceptsLate-onset sepsisNewborn intensive care unitIntensive care unitCare unitBirth weightIntensive care unit populationNeonatal late-onset sepsisRetrospective cohort analysisTotal parenteral nutritionRespiratory distress syndromeGenetic factorsLogistic regression analysisMixed-effects logistic regressionNongenetic factorsMixed-effects logistic regression analysisSignificant genetic susceptibilityDistress syndromeParenteral nutritionGestational ageCohort analysisSepsisUnit populationConcordance rateGenetic susceptibilityLogistic regression
2006
Substance-abusing mothers and disruptions in child custody: An attachment perspective
Suchman NE, McMahon TJ, Zhang H, Mayes LC, Luthar S. Substance-abusing mothers and disruptions in child custody: An attachment perspective. Journal Of Substance Use And Addiction Treatment 2006, 30: 197-204. PMID: 16616163, PMCID: PMC1850760, DOI: 10.1016/j.jsat.2005.11.008.Peer-Reviewed Original ResearchConceptsAttachment perspectiveInternal psychological processesMothers' perceptionsParental Bonding InstrumentSubstance-abusing mothersPsychological maladjustmentPsychological processesMultilevel modeling approachAttachment frameworkAddiction Severity IndexSubstance abuseChild placementDemographic questionnaireChild custodyPerceptionComposite scoreMethadone maintenance programMaladjustmentParentingMothersAbuseParentsPerspectiveSeverity IndexChildren
2003
Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study
Merikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J. Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study. JAMA Psychiatry 2003, 60: 993-1000. PMID: 14557144, DOI: 10.1001/archpsyc.60.9.993.Peer-Reviewed Original ResearchConceptsComorbid anxietyDiagnostic thresholdZurich cohort studyLong-term followCommunity-based cohortMajor mental disordersProspective community studyCommunity-based sampleCohort studyProspective studyComorbid statesAffective disordersMental disordersDiagnostic InterviewMid adulthoodCanton of ZurichCommunity studyAnxiety statesSubthreshold levelsAssessment pointsDepressionDisordersLongitudinal trajectoriesTreatment researchAnxiety
2002
Toward validation of atypical depression in the community: results of the Zurich cohort study
Angst J, Gamma A, Sellaro R, Zhang H, Merikangas K. Toward validation of atypical depression in the community: results of the Zurich cohort study. Journal Of Affective Disorders 2002, 72: 125-138. PMID: 12200203, DOI: 10.1016/s0165-0327(02)00169-6.Peer-Reviewed Original ResearchConceptsZurich cohort studyAtypical depressionCohort studyAtypical subtypeAtypical major depressive episodeCommunity-based longitudinal cohort studyDSM-IV atypical depressionAtypical depressive subtypesSignificant female preponderanceSex differencesAtypical depressive symptomsPopulation-based cohortMajor depressive episodeLongitudinal cohort studyHigh population prevalenceMood reactivitySymptom Checklist-90Marked sex differenceFemale preponderanceTreatment patternsAtypical syndromesClinical correlatesDepressive episodeDepressive subtypesClinical severityThe spectrum of social phobia in the zurich cohort study of young adults
Merikangas KR, Avenevoli S, Acharyya S, Zhang H, Angst J. The spectrum of social phobia in the zurich cohort study of young adults. Biological Psychiatry 2002, 51: 81-91. PMID: 11801233, DOI: 10.1016/s0006-3223(01)01309-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetCatchment Area, HealthCognitive Behavioral TherapyCohort StudiesComorbidityCuesFemaleHumansInterpersonal RelationsMalePersonalityPhobic DisordersPrevalencePsychiatric Status Rating ScalesSeverity of Illness IndexSocial PerceptionSubstance-Related DisordersSwitzerlandTemperamentConceptsDiagnostic thresholdProspective-longitudinal community studySocial phobiaYoung adultsZurich cohort studyHigher lifetime ratesLongitudinal community studyPercent of participantsSocial phobia symptomsCohort studyMedication useStudy entryWork impairmentClinical indicatorsRisk factorsUndiagnosed casesFamily historyEqual gender ratioAge 35Phobia symptomsGeneral populationLifetime ratesLongitudinal courseTreatment ratesCommunity study
1998
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. Pediatrics 1998, 102: 14-19. PMID: 9651407, DOI: 10.1542/peds.102.1.14.Peer-Reviewed Original ResearchConceptsYears of ageTic severityTS patientsTourette syndromeSeverity of ticsInitial clinical evaluationDecades of lifeConsistent time courseOnset of pubertyPatient's coursePrognostic valueTic onsetYale Child Study CenterClinical evaluationBirth-year cohortsPrevalence studyPatientsSeverityStudy centersChild Study CenterIdentification of factorsSevere levelsAgeProgressive patternSyndrome