2009
Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder
Lin H, Williams KA, Katsovich L, Findley DB, Grantz H, Lombroso PJ, King RA, Bessen DE, Johnson D, Kaplan EL, Landeros-Weisenberger A, Zhang H, Leckman JF. Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder. Biological Psychiatry 2009, 67: 684-691. PMID: 19833320, PMCID: PMC2843763, DOI: 10.1016/j.biopsych.2009.08.020.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsAttention Deficit Disorder with HyperactivityChildDepressive DisorderFemaleForecastingHumansLife Change EventsMaleObsessive-Compulsive DisorderPredictive Value of TestsProspective StudiesPsychologyRespiratory Tract InfectionsSeverity of Illness IndexStreptococcal InfectionsTicsTourette SyndromeConceptsDepressive symptom severityObsessive-compulsive disorderGABHS infectionPsychosocial stressTourette syndromeSymptom severityControl subjectsStreptococcal upper respiratory tract infectionUpper respiratory tract infectionBeta-hemolytic streptococcal infectionCurrent psychosocial stressRespiratory tract infectionsHealthy control subjectsProspective longitudinal studyEarly-onset obsessive-compulsive disorderMinority of childrenOC symptom severityTract infectionsStreptococcal infectionGABHS infectionsObsessive-compulsive symptom severityClinical ratingsNew infectionsClinical ratersControl status
2006
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder
Lin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.Peer-Reviewed Original ResearchConceptsDepressive symptom severityFuture depressive symptomsHealthy control subjectsObsessive-compulsive disorderDepressive symptomsPsychosocial stressTourette syndromeSymptom severityControl subjectsLong-term contextual threatSeverity of ticsProspective longitudinal studyChronological ageIndependent predictorsOC symptomsTic severityOC symptom severityPsychosocial adversitySymptomsFuture symptom severityClinician ratingsSeverityParental reportsSignificant predictorsLongitudinal studyAdulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisordersAssessing Sex Differences on Treatment Effectiveness from the Drug Abuse Treatment Outcome Study (DATOS)
Acharyya S, Zhang H. Assessing Sex Differences on Treatment Effectiveness from the Drug Abuse Treatment Outcome Study (DATOS). The American Journal Of Drug And Alcohol Abuse 2003, 29: 415-444. PMID: 12765214, DOI: 10.1081/ada-120020524.Peer-Reviewed Original ResearchConceptsDrug Abuse Treatment Outcome StudyTreatment modalitiesTreatment effectivenessDrug treatment programsEffects of drugsTreatment outcome studiesClinical differencesTreatment successOutcome studiesTreatment programSeverity IndexDemographic characteristicsWomenDemographic covariatesSex differencesSexMenCumulative logit modelModalitiesGender-based variation
2002
Toward validation of atypical depression in the community: results of the Zurich cohort study
Angst J, Gamma A, Sellaro R, Zhang H, Merikangas K. Toward validation of atypical depression in the community: results of the Zurich cohort study. Journal Of Affective Disorders 2002, 72: 125-138. PMID: 12200203, DOI: 10.1016/s0165-0327(02)00169-6.Peer-Reviewed Original ResearchConceptsZurich cohort studyAtypical depressionCohort studyAtypical subtypeAtypical major depressive episodeCommunity-based longitudinal cohort studyDSM-IV atypical depressionAtypical depressive subtypesSignificant female preponderanceSex differencesAtypical depressive symptomsPopulation-based cohortMajor depressive episodeLongitudinal cohort studyHigh population prevalenceMood reactivitySymptom Checklist-90Marked sex differenceFemale preponderanceTreatment patternsAtypical syndromesClinical correlatesDepressive episodeDepressive subtypesClinical severityThe spectrum of social phobia in the zurich cohort study of young adults
Merikangas KR, Avenevoli S, Acharyya S, Zhang H, Angst J. The spectrum of social phobia in the zurich cohort study of young adults. Biological Psychiatry 2002, 51: 81-91. PMID: 11801233, DOI: 10.1016/s0006-3223(01)01309-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetCatchment Area, HealthCognitive Behavioral TherapyCohort StudiesComorbidityCuesFemaleHumansInterpersonal RelationsMalePersonalityPhobic DisordersPrevalencePsychiatric Status Rating ScalesSeverity of Illness IndexSocial PerceptionSubstance-Related DisordersSwitzerlandTemperamentConceptsDiagnostic thresholdProspective-longitudinal community studySocial phobiaYoung adultsZurich cohort studyHigher lifetime ratesLongitudinal community studyPercent of participantsSocial phobia symptomsCohort studyMedication useStudy entryWork impairmentClinical indicatorsRisk factorsUndiagnosed casesFamily historyEqual gender ratioAge 35Phobia symptomsGeneral populationLifetime ratesLongitudinal courseTreatment ratesCommunity study
2001
Thermal Sensitivity in Tourette Syndrome: Preliminary Report
Scahill L, Lombroso P, Mack G, Van Wattum P, Zhang H, Vitale A, Leckman J. Thermal Sensitivity in Tourette Syndrome: Preliminary Report. Perceptual And Motor Skills 2001, 92: 419-432. PMID: 11361302, DOI: 10.2466/pms.2001.92.2.419.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Temperature RegulationFemaleHumansMalePrevalenceSeverity of Illness IndexTicsTime FactorsTourette SyndromeConceptsTourette syndromeSubgroup of patientsAge of onsetAdult male subjectsCurrent ageTic symptomsDopaminergic pathwaysSex distributionCurrent severityMale subjectsMean differenceSyndromeControl periodPreliminary reportSweat rateAgeSymptomsSubjectsOverall courseDegrees COnsetPatientsIllnessSeverityCourse
2000
Model for the Analysis of Binary Time Series of Respiratory Symptoms
Zhang H, Triche E, Leaderer B. Model for the Analysis of Binary Time Series of Respiratory Symptoms. American Journal Of Epidemiology 2000, 151: 1206-1215. PMID: 10905533, DOI: 10.1093/oxfordjournals.aje.a010171.Peer-Reviewed Original ResearchConceptsDuration of symptomsRespiratory symptomsNew episodesStuffy nosePrior historyHistory of allergyDaily respiratory symptomsInfant Health StudyMeteorologic changesHealth StudySymptomsEpidemiologic researchDay careMarital statusIncidenceEnvironmental epidemiologic researchEpisodesMothersDurationSulfate levelsHusband's levelDemographic variablesNoseHigh levelsAllergy
1999
Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children
SCAHILL L, SCHWAB-STONE M, MERIKANGAS K, LECKMAN J, ZHANG H, KASL S. Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 976-984. PMID: 10434489, DOI: 10.1097/00004583-199908000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD groupCommunity sampleFamily dysfunctionSubthreshold attention-deficit hyperactivity disorderGlobal Assessment ScaleDisruptive behavior disordersChildren's Global Assessment ScaleStructured diagnostic interviewPsychiatric comorbiditySchool-aged childrenADHD statusHyperactivity disorderPsychosocial adversityExcessive alcohol useDimensional approachDiagnostic InterviewLow-income familiesAlcohol useBehavior disorderClinical correlatesSubthreshold groupChildrenAssessment ScalePsychiatric treatment
1998
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.Peer-Reviewed Original ResearchConceptsTic suppressionTourette syndromeTic symptomsBasal gangliaPathogenesis of ticsVoluntary tic suppressionMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySubcortical neural circuitsFunctional magnetic resonance imagingMagnetic resonance imagingConnected cortical regionsRegional signal changesImpaired modulationSignal changesFunctional debilityNeuronal activityResonance imagingAdult subjectsImaging studiesCortical regionsNeuropsychiatric disordersNeural circuitsSyndrome
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsion