2023
ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES
Hosseinzadeh P, Schone E, Peck J, Craig L, Zhang H, Legro R, Diamond M, Santoro N, Hansen K. ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES. Fertility And Sterility 2023, 120: e170-e171. DOI: 10.1016/j.fertnstert.2023.08.507.Peer-Reviewed Original ResearchModerate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomenAnti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause
Santoro N, Flyckt R, Davis A, Finkelstein J, Crawford S, Sun F, Derby C, Morrison A, Sluss P, Zhang H. Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause. Obstetrics And Gynecology 2023, 141: 331-340. PMID: 36649324, PMCID: PMC9858351, DOI: 10.1097/aog.0000000000005049.Peer-Reviewed Original ResearchConceptsFinal menstrual periodAnti-Müllerian hormone levelsAMH levelsNatural menopauseHormone levelsUndetectable AMH levelsCommunity-based studyOvarian conservationOvarian reserveAMH measurementOvarian failureMenstrual periodSurgery dateHysterectomyLinear mixed modelingMenopauseSurvival analysisPatientsImmediate reductionMixed modelingWomenOvariesSimilar patternRapid declineBSO
2022
Live Birth With or Without Preimplantation Genetic Testing for Aneuploidy
Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro R, Chen Z. Live Birth With or Without Preimplantation Genetic Testing for Aneuploidy. Obstetrical & Gynecological Survey 2022, 77: 159-161. DOI: 10.1097/01.ogx.0000822436.67205.20.Peer-Reviewed Original ResearchPreimplantation genetic testingLive birth rateIn vitro fertilizationPGT-AGenetic testingWomen of advanced maternal ageIncreased live birth rateAdvanced maternal ageBirth experienceHigh quality embryosBirth rateMaternal ageQuality embryosLive birthsMorphology scorePreimplantationAneuploidyGenetic statusWomenPrognosisScoresBirthEffect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial
Barnhart K, Hansen K, Stephenson M, Usadi R, Steiner A, Cedars M, Jungheim E, Hoeger K, Krawetz S, Mills B, Alston M, Coutifaris C, Senapati S, Sonalkar S, Diamond M, Wild R, Rosen M, Sammel M, Santoro N, Eisenberg E, Huang H, Zhang H. Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial. Obstetrical & Gynecological Survey 2022, 77: 24-26. DOI: 10.1097/01.ogx.0000805156.32421.70.Peer-Reviewed Original Research
2020
Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction
Vitek W, Sun F, Hoeger KM, Santoro N, Diamond MP, Zhang H, Legro RS, Network E, Coutifaris C, Christman G, Robinson R, Brzyski R, Schlaff W, Casson P, Trussell J, Eisenberg E, Lamar C, DePaolo L. Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction. Fertility And Sterility 2020, 114: 1032-1039. PMID: 33036790, PMCID: PMC7953832, DOI: 10.1016/j.fertnstert.2020.06.002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeShort-term weight changeUnexplained infertilityLive birth rateOvulation inductionOvary syndromeWeight changeWeight gainCycles of clomipheneBody mass indexMean weight changeBirth rateRandomized trialsMass indexRegular intercourseIntrauterine inseminationTreatment allocationLive birthsMAIN OUTCOMESecondary analysisWomenWeight assessmentBirthSyndromeInfertility
2019
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis
Wang R, Li W, Bordewijk E, Legro R, Zhang H, Wu X, Gao J, Morin-Papunen L, Homburg R, König T, Moll E, Kar S, Huang W, Johnson N, Amer S, Vegetti W, Palomba S, Falbo A, Özmen Ü, Nazik H, Williams C, Federica G, Lord J, Sahin Y, Bhattacharya S, Norman R, van Wely M, Mol B, Network+ R, Collaboration T. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update 2019, 25: 717-732. PMID: 31647106, DOI: 10.1093/humupd/dmz029.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical pregnancy rateClomiphene citrateLive birth rateOvulation inductionTime-to-pregnancyAnovulatory infertilityFrequent cause of anovulatory infertilityPregnancy rateCause of anovulatory infertilityBirth rateMetformin to CCOvulation induction agentsIncreased clinical pregnancyLive birthsPrimary randomised controlled trialsClinical pregnancyRandomised controlled trialsInfertilityIndividual participant dataIPD meta-analysesWomenPositive interactionsLetrozoleAccurate assessment of outcomes
2018
Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility
Vitek W, Sun F, Hoeger K, Santoro N, Diamond M, Zhang H, Legro R. Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility. Fertility And Sterility 2018, 110: e68. DOI: 10.1016/j.fertnstert.2018.07.207.Peer-Reviewed Original ResearchPolycystic ovary syndrome and autism: A test of the prenatal sex steroid theory
Cherskov A, Pohl A, Allison C, Zhang H, Payne RA, Baron-Cohen S. Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory. Translational Psychiatry 2018, 8: 136. PMID: 30065244, PMCID: PMC6068102, DOI: 10.1038/s41398-018-0186-7.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical Practice Research DatalinkOvary syndromeOdds ratioPrevalence of PCOSRisk of PCOSMaternal metabolic conditionsMaternal psychiatric diagnosisChildren of womenCase-control studyPrenatal testosteroneRisk of autismElectronic health recordsObstetric complicationsSex steroidsPsychiatric diagnosisGreater riskMetabolic conditionsElevated levelsHealth recordsWomenSyndromeChildrenRiskTestosteroneTransfer of Fresh Versus Frozen Embryos in Ovulatory Women
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro R, Chen Z. Transfer of Fresh Versus Frozen Embryos in Ovulatory Women. Obstetrical & Gynecological Survey 2018, 73: 213-214. DOI: 10.1097/ogx.0000000000000546.Peer-Reviewed Original ResearchEffect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome
Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro R, Zhang H, Chen Z. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2018, 73: 158-159. DOI: 10.1097/01.ogx.0000532005.07471.0c.Peer-Reviewed Original Research
2016
Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial
Pal L, Zhang H, Williams J, Santoro NF, Diamond MP, Schlaff WD, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers E, Legro RS, Network F. Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 3027-3035. PMID: 27186859, PMCID: PMC4971341, DOI: 10.1210/jc.2015-4352.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birthsVitD statusOvary syndromeSerum 25OHDIndependent predictorsSecondary analysisOvulation induction outcomesSerum 25OHD levelsVitamin D statusHealth diagnostic criteriaD statusNonpregnant populationRetrospective cohortControlled TrialsVitamin DPregnancy lossReproductive outcomesDiagnostic criteriaTrial dataProgressive improvementWomenInduction outcomeNational InstituteSyndrome
2015
Recruitment strategies in two reproductive medicine network infertility trials
Usadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R, Network F. Recruitment strategies in two reproductive medicine network infertility trials. Contemporary Clinical Trials 2015, 45: 196-200. PMID: 26386293, PMCID: PMC4766588, DOI: 10.1016/j.cct.2015.09.010.Peer-Reviewed Original ResearchConceptsPPCOS IIMultiple Intrauterine GestationsPolycystic ovary syndromeRecruitment strategiesSuccessful recruitment strategiesInfertility trialsOvarian stimulationIntrauterine gestationOvary syndromeWhite patientsBlack patientsDifferent recruitment strategiesPhysician referralClinical trialsInfertile couplesTrial completionClinical sitesTrialsRecruitment methodsPatientsSimilar ratesPhysiciansWomenParticipantsSuccessful strategyAntithyroid antibodies, but not thyroid stimulating hormone, are associated with decreased pregnancy rates in infertile women
Seungdamrong A, Steiner A, Gracia C, Diamond M, Legro R, Jin S, Eisenberg E, Zhang H, Santoro N. Antithyroid antibodies, but not thyroid stimulating hormone, are associated with decreased pregnancy rates in infertile women. Fertility And Sterility 2015, 104: e36-e37. DOI: 10.1016/j.fertnstert.2015.07.111.Peer-Reviewed Original ResearchCluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotypeOccupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study
Bassig BA, Friesen MC, Vermeulen R, Shu XO, Purdue MP, Stewart PA, Xiang YB, Chow WH, Zheng T, Ji BT, Yang G, Linet MS, Hu W, Zhang H, Zheng W, Gao YT, Rothman N, Lan Q. Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study. Environmental Health Perspectives 2015, 123: 971-977. PMID: 25748391, PMCID: PMC4590744, DOI: 10.1289/ehp.1408307.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaShanghai Women's Health StudyWomen's Health StudyBenzene exposureHealth StudyNHL riskOccupational exposurePopulation-based prospective cohortCox proportional hazards modelInconsistent epidemiologic evidenceCancer Working GroupProportional hazards modelOccupational benzene exposureCumulative exposure levelsExposure tertilesUnexposed womenProspective cohortEpidemiologic evidenceHigh riskOccupational historyHazards modelExposure levelsWomenHigh associationExposure metrics
2014
0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai
Bassig B, Friesen M, Vermeulen R, Shu X, Purdue M, Stewart P, Lu W, Xiang Y, Chow W, Zheng T, Ji B, Yang G, Linet M, Hu W, Zhang H, Zheng W, Gao Y, Rothman N, Lan Q. 0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai. Occupational And Environmental Medicine 2014, 71: a40. DOI: 10.1136/oemed-2014-102362.125.Peer-Reviewed Original ResearchPopulation-based cohort studyNon-Hodgkin lymphomaCohort studyBenzene exposureOccupational exposureNHL riskPopulation-based prospective cohortChinese womenCox proportional hazards modelProportional hazards modelOccupational benzene exposureCumulative exposure levelsIARC Working GroupExposure tertilesUnexposed womenProspective cohortElevated riskOccupational historyHazards modelLymphomaLimited evidenceWomenElevated associationExposure levelsExposure metrics
2013
Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial
Kuang H, Li Y, Wu X, Hou L, Wu T, Liu J, Ng EH, Stener-Victorin E, Legro RS, Zhang H. Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial. Evidence-based Complementary And Alternative Medicine 2013, 2013: 527303. PMID: 24023577, PMCID: PMC3762180, DOI: 10.1155/2013/527303.Peer-Reviewed Original ResearchPolycystic ovary syndromeControl acupuncturePCOS womenTrue acupunctureOvary syndromeLive birthsEfficacy of acupunctureLive birth rateFirst-line medicineSafety monitoring boardClomiphene citrateOngoing multicenterAdjuvant treatmentOvulation inductionControlled TrialsTreatment armsAlternative therapiesMonitoring boardAcupunctureFertility treatmentCentral mechanismsStudy designTrialsBirth rateWomen
2012
Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome
Roth LW, Huang H, Legro RS, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Schlaff WD. Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 1151-1156. PMID: 22617579, PMCID: PMC3360417, DOI: 10.1097/aog.0b013e31825618fb.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFerriman-Gallwey scoreClomiphene citrateOvary syndromePolycystic Ovary Syndrome IDouble-blind trialDuration of treatmentAbsence of ovulationHirsutism scoreOvulation inductionHirsute womenHirsutismSecondary analysisMetforminWomenGroup assignmentSignificant decreaseSignificant differencesTreatmentSyndromeInfertilityGreater improvementScoresPregnancyGroupEndometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome
Diamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 902-908. PMID: 22525900, PMCID: PMC4007263, DOI: 10.1097/aog.0b013e31824da35c.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birth rateAnovulatory cyclesEndometrial sheddingClomiphene citrateOvary syndromeLive birthsEunice Kennedy Shriver National InstituteBirth rateCommon clinical practiceOccurrence of ovulationRate of conceptionAnovulatory womenOvarian stimulationOvulation inductionSpontaneous mensesProgestin withdrawalChild healthClinical practiceNetwork trialSecondary analysisOvulation rateMetforminAdverse effectsWomen