Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
Xu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, Britton J, Neugut A, Santella R, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28: 1504-1509. PMID: 17372271, DOI: 10.1093/carcin/bgm061.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismRate-limiting enzymeThymidylate synthaseRate-limiting genesOne-carbon pathwayDNA methylationEpigenetic processesSame pathwayGenesMethylenetetrahydrofolate reductaseDNA synthesisEnzymePathwayCritical rolePolymorphismSame populationCancer etiologyPopulation-based Long Island Breast Cancer Study ProjectMetabolismFunctional polymorphismsRepeat alleleMethylationReductaseAllelesSynthase