2019
Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial
Wei D, Liu J, Sun Y, Shi Y, Zhang B, Liu J, Tan J, Liang X, Cao Y, Wang Z, Qin Y, Zhao H, Zhou Y, Ren H, Hao G, Ling X, Zhao J, Zhang Y, Qi X, Zhang L, Deng X, Chen X, Zhu Y, Wang X, Tian L, Lv Q, Ma X, Zhang H, Legro R, Chen Z. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. The Lancet 2019, 393: 1310-1318. PMID: 30827784, DOI: 10.1016/s0140-6736(18)32843-5.Peer-Reviewed Original ResearchConceptsFrozen single blastocyst transferFresh single blastocyst transferSingle blastocyst transferElective single embryo transferRisk of pre-eclampsiaFrozen blastocyst transferBlastocyst transferLivebirth rateSevere ovarian hyperstimulation syndromePre-eclampsiaOvulatory womenPregnancy rateEmbryo transferOvarian hyperstimulation syndromeAcademic fertility centreFrozen-thawed single blastocyst transferHigher risk of pre-eclampsiaIn vitro fertilisationIncreased risk of pre-eclampsiaFrozen embryo transferExtended embryo cultureSingle embryo transferFertility centreHyperstimulation syndromeLower pregnancy rate
2018
Transfer of Fresh versus Frozen Embryos in Ovulatory Women
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro R, Chen Z. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. New England Journal Of Medicine 2018, 378: 126-136. PMID: 29320646, DOI: 10.1056/nejmoa1705334.Peer-Reviewed Original ResearchConceptsFresh embryo transferFrozen embryo transferLive birth rateOvarian hyperstimulation syndromeHyperstimulation syndromeElective frozen embryo transferOvulatory womenFrozen-embryo groupFresh embryo groupIn vitro fertilization cyclesHigher live birth ratesPolycystic ovary syndromeRate of implantsCleavage-stage embryosOverall pregnancy lossAnovulatory womenNeonatal complicationsClinical pregnancyOngoing pregnancyFrozen embryosEmbryo cryopreservationBetween-group differencesEmbryo transferLive birthsFertilization cycles
2016
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome
Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2016, 375: 523-533. PMID: 27509101, DOI: 10.1056/nejmoa1513873.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvarian hyperstimulation syndromeFresh embryo transferFrozen embryo transferFrozen-embryo transferOvary syndromeHyperstimulation syndromeLive birthsInfertile womenRate ratioFrozen embryosSignificant between-group differencesFresh embryo groupFirst IVF cycleLive birth rateFirst embryo transferBetween-group differencesNeonatal complicationsIVF cyclesPregnancy complicationsMulticenter trialPrimary outcomeNeonatal deathPregnancy lossHigh risk
2015
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond M, Legro R, Coutifaris C, Alvero R, Robinson R, Casson P, Christman G, Ager J, Huang H, Hansen K, Baker V, Usadi R, Seungdamrong A, Bates G, Rosen R, Haisenleder D, Krawetz S, Barnhart K, Trussell J, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. Obstetrical & Gynecological Survey 2015, 70: 757-758. DOI: 10.1097/ogx.0000000000000275.Peer-Reviewed Original ResearchOvarian stimulationUnexplained infertilityMultiple gestationsLetrozole groupCongenital anomaliesPregnancy rateLive birthsNormal uterine cavityStandard therapy groupUse of clomipheneOvarian hyperstimulation syndromeFirst-line therapyLive birth ratePatent fallopian tubesPolycystic ovary syndromeMultiple gestation ratesCause of infertilityPlacebo control groupNormal sperm countYears of ageImproved pregnancy ratesFetal heart activityHyperstimulation syndromeMonofollicular developmentNeonatal complications
2011
Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
Diamond MP, Mitwally M, Casper R, Ager J, Legro RS, Brzyski R, Casson P, Eisenberg E, Zhang H, Network F. Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Contemporary Clinical Trials 2011, 32: 902-908. PMID: 21787883, PMCID: PMC3708642, DOI: 10.1016/j.cct.2011.07.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAromatase InhibitorsClomipheneDose-Response Relationship, DrugDouble-Blind MethodFemaleFertility Agents, FemaleGonadotropinsHumansInfant, NewbornInfertilityLetrozoleMaleNitrilesOvulation InductionPregnancyPregnancy OutcomePregnancy, MultipleProspective StudiesTreatment OutcomeTriazolesYoung AdultConceptsMultiple Intrauterine GestationsMultiple gestation pregnanciesOvulation inductionUnexplained infertilityGestation pregnanciesIntrauterine gestationMultiple gestationsComparable pregnancy ratesMono-follicular developmentOvarian stimulation (AMIGOS) trialOvarian hyperstimulation syndromePregnancy success ratePublic health benefitsExpense of careHyperstimulation syndromeClomiphene citrateNeonatal morbidityPreterm laborFertility medicationsPreterm infantsIntrauterine inseminationStimulation trialsAromatase inhibitorsPregnancy rateGestation