2019
Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility.
Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. Journal Of Urology 2019, 202: 379-384. PMID: 30835629, PMCID: PMC6686175, DOI: 10.1097/ju.0000000000000205.Peer-Reviewed Original ResearchConceptsQuality of lifeLow total testosteroneTotal testosteroneErectile dysfunctionUnexplained infertilityFertiQoL scoresTestosterone levelsSemen parametersLow total testosterone levelsMultivariable logistic regression analysisMale partnersBaseline semen analysisWorse erectile dysfunctionTotal testosterone levelsAbnormal semen qualityPrimary study outcomePHQ-9 scoresBody mass indexMen of couplesLogistic regression analysisInfertility durationMen 59IIEF scorePatient ageSD ageAssociation between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population
Trussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Heisenleder D, Smith J, Steiner A, Wild R, Casson P, Coutifaris C, Alvero RR, Robinson RB, Christman G, Patrizio P, Zhang H, Lindgren MC, Network R. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility And Sterility 2019, 111: 1129-1134. PMID: 30982604, PMCID: PMC6557574, DOI: 10.1016/j.fertnstert.2019.01.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersDown-RegulationFemaleFertilityHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMaleMulticenter Studies as TopicPregnancyPregnancy RateRandomized Controlled Trials as TopicRisk FactorsSperm CountSperm MotilitySpermatogenesisTestosteroneTreatment OutcomeConceptsUnexplained infertilityLow TTMale partnersLive birthsSemen parametersSecondary analysisMultiple Intrauterine GestationsLive birth rateBody mass indexMulticenter clinical trialAbnormal sperm morphologyOvarian stimulationIntrauterine gestationPregnancy outcomesMass indexInfertility clinicClinical trialsMAIN OUTCOMETotal motile spermSemen analysisAbnormal spermatogenesisInfertilityLogistic regressionSperm concentrationSemen volume
2018
Major depression, antidepressant use, and male and female fertility
Evans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, Casson PR, Christman GM, Hansen KR, Zhang H, Santoro N, Steiner AZ, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Ager J, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Lecks K, Martino L, Marunich R, Comfort A, Crow M, Hohmann A, Mallette S, Smith Y, Randolph J, Fisseha S, Ohl D, Ringbloom M, Tang J, Bates W, Mason S, Craig L, Zornes C, Rodriguez M, Hunt T, DiMaria N, Usadi R, Lucidi S, Rhea M, Baker V, Turner K, Brennan M, DelBasso D, Huang H, Jin Y, Li Y, Kuang H, Makuch R, Patrizio P, Sakai L, Scahill L, Song C, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Trussell J, Laylor B, Martinez L, Solnica A, Wojtczuk A, Seungdamrong A, Rosen M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Major depression, antidepressant use, and male and female fertility. Fertility And Sterility 2018, 109: 879-887. PMID: 29778387, PMCID: PMC5973807, DOI: 10.1016/j.fertnstert.2018.01.029.Peer-Reviewed Original ResearchConceptsMaternal major depressionMaternal antidepressant useAntidepressant useLikelihood of pregnancyMale partnersMajor depressionNon-IVF fertility treatmentsFirst trimester pregnancy lossTypes of antidepressantsPHQ-9 scoresFirst trimester miscarriagePatient Health QuestionnairePoor fertility outcomesRisk of miscarriagePoisson regression modelsPPCOS IICohort studyPregnancy outcomesMedication usePrimary outcomeRandomized trialsPregnancy lossHealth QuestionnaireRelative riskTreatment outcomesMP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITY
Coward R, Stetter C, Kunselman A, Trussell J, Lindgren M, Diamond M, Hansen K, Krawetz S, Legro R, Patrizio P, Smith J, Steiner A, Wild R, Eisenberg E, Zhang H, Santoro N. MP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITY. Journal Of Urology 2018, 199: e249. DOI: 10.1016/j.juro.2018.02.663.Peer-Reviewed Original Research
2016
Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndrome
Santoro N, Eisenberg E, Trussell JC, Craig LB, Gracia C, Huang H, Alvero R, Casson P, Christman G, Coutifaris C, Diamond M, Jin S, Legro RS, Robinson RD, Schlaff WD, Zhang H. Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndrome. Human Reproduction 2016, 31: 2268-2279. PMID: 27402910, PMCID: PMC5027926, DOI: 10.1093/humrep/dew175.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFertility-related qualityFertiQoL scoresUnexplained infertilityPregnancy outcomesLower QoLOvary syndromeMale partnersInfertility diagnosisQOL surveyFerring PharmaceuticalsWorldwide cohortPolycystic Ovary Syndrome IIWilcoxon rank-sum testingFirst patient enrollmentMultiple Intrauterine GestationsTime of enrollmentPARTICIPANTS/MATERIALSRank-sum testingNational InstitutePopulation-based sampleROLE OF CHANCEKey participant characteristicsLow socioeconomic statusHirsutism score
2014
Letrozole or Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro RS, Zhang H. Letrozole or Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 1462-1464. PMID: 25295506, DOI: 10.1056/nejmc1409550.Peer-Reviewed Original ResearchLetrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro R, Brzyski R, Diamond M, Coutifaris C, Schlaff W, Casson P, Christman G, Huang H, Yan Q, Alvero R, Haisenleder D, Barnhart K, Bates G, Usadi R, Lucidi S, Baker V, Trussell J, Krawetz S, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2014, 69: 599-601. DOI: 10.1097/01.ogx.0000456355.64379.77.Peer-Reviewed Original ResearchPolycystic ovary syndromeAdverse effect profileMultiple pregnancy rateEffect profileFertility agentsAromatase inhibitorsLive birthsHigher multiple pregnancy rateLower multiple pregnancy rateSelective estrogen receptor modulatorsMale partnersNormal uterine cavityPatent fallopian tubesPrimary study outcomeCumulative live birthReproductive-age womenGood safety profileEstrogen receptor modulatorsClomiphene groupLetrozole groupClomiphene citrateRotterdam criteriaHot flushesOvary syndromeInfertile women
2011
Recruitment challenges of a multicenter randomized controlled varicocelectomy trial
Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H, Network R. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertility And Sterility 2011, 96: 1299-1305. PMID: 22130101, PMCID: PMC3243664, DOI: 10.1016/j.fertnstert.2011.10.025.Peer-Reviewed Original ResearchConceptsReproductive Medicine NetworkPlacebo armInfertility evaluationIntrauterine inseminationMedicine NetworkSuboptimal recruitmentClinical trial enrollmentMale infertility studiesAscertain reasonsIUI cyclesInfertile womenTrial enrollmentSurgical interventionPatient educationMAIN OUTCOMEStudy recruitmentInfertile menMale infertilityStudy participantsInfertility studiesMale partnersRecruitment challengesTrialsInadequate recruitmentFertility interventions