2015
Genes and environment in neonatal intraventricular hemorrhage
Ment LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, Lin A, Cotten CM, Murray J, Page G, Hallman M, Lifton RP, Zhang H, Network O. Genes and environment in neonatal intraventricular hemorrhage. Seminars In Perinatology 2015, 39: 592-603. PMID: 26516117, PMCID: PMC4668116, DOI: 10.1053/j.semperi.2015.09.006.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhagePreterm neonatesLow birth weight preterm neonatesSevere intraventricular hemorrhageWeight preterm neonatesNeonatal intraventricular hemorrhageCerebral blood flowBlood flowVascular pathwaysCandidate gene studiesGenetic factorsComplex disorderHemorrhageNeonatesAngiogenesisGene studiesGenome-wide association studies
2014
Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates
Shankaran S, Lin A, Maller-Kesselman J, Zhang H, O'Shea TM, Bada HS, Kaiser JR, Lifton RP, Bauer CR, Ment LR, Study G. Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates. The Journal Of Pediatrics 2014, 164: 1005-1011.e3. PMID: 24589078, PMCID: PMC4095864, DOI: 10.1016/j.jpeds.2014.01.036.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanBlack PeopleCase-Control StudiesCerebral HemorrhageFemaleHealthcare DisparitiesHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLogistic ModelsMaleMultivariate AnalysisPregnancyPrenatal CareRisk FactorsSocioeconomic FactorsSwedenUltrasonographyUnited StatesWhite PeopleConceptsIntraventricular hemorrhageWhite infantsGrade 2Multiple gestationsPrenatal visitWhite raceNeonatal intensive care unitAntenatal steroid exposureGestational age infantsBirth weight 500Birth weight rangeIntensive care unitAfrican ancestryMultivariate logistic regressionHigher maternal educationHigh-frequency ventilationHealth care disparitiesAntenatal steroidsApgar scoreCesarean deliveryPreterm neonatesCare unitGestational ageSteroid exposureAge infants
2013
Gene–environment interactions in severe intraventricular hemorrhage of preterm neonates
Ment LR, Ådén U, Lin A, Kwon SH, Choi M, Hallman M, Lifton RP, Zhang H, Bauer CR. Gene–environment interactions in severe intraventricular hemorrhage of preterm neonates. Pediatric Research 2013, 75: 241-250. PMID: 24192699, PMCID: PMC3946468, DOI: 10.1038/pr.2013.195.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApgar ScoreBlood CoagulationCerebral VentriclesCerebrovascular CirculationCollagen Type IVFactor VGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGestational AgeHumansHypoxia, BrainInfantInfant, PrematureInflammation MediatorsIntracranial HemorrhagesMethylenetetrahydrofolate Reductase (NADPH2)PhenotypePremature BirthPrognosisRisk FactorsConceptsIntraventricular hemorrhageCerebral injuryPreterm neonatesFactor V Leiden geneRisk of IVHEnvironmental triggersSevere intraventricular hemorrhageCerebral blood flowMethylenetetrahydrofolate reductase (MTHFR) variantsUnknown environmental triggersPresence of mutationsPeriventricular infarctionApgar scorePerinatal hypoxiaPreclinical dataFetal environmentGerminal matrixCerebral vasculatureBlood flowT polymorphismGene-environment interactionsMTHFR 677CHemorrhageNeonatesVascular pathwaysCandidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates
Ådén U, Lin A, Carlo W, Leviton A, Murray JC, Hallman M, Lifton RP, Zhang H, Ment LR, Group G. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates. The Journal Of Pediatrics 2013, 163: 1503-1506.e1. PMID: 23896193, PMCID: PMC3812267, DOI: 10.1016/j.jpeds.2013.06.025.Peer-Reviewed Original Research