2023
ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES
Hosseinzadeh P, Schone E, Peck J, Craig L, Zhang H, Legro R, Diamond M, Santoro N, Hansen K. ASSOCIATION OF FOLLICULAR PHASE LENGTH (FPL) AND EARLY PREGNANCY LOSS (EPL) IN WOMEN WITH UNEXPLAINED INFERTILITY UNDERGOING OVARIAN STIMULATION WITH INTRAUTERINE INSEMINATION (OS-IUI) CYCLES. Fertility And Sterility 2023, 120: e170-e171. DOI: 10.1016/j.fertnstert.2023.08.507.Peer-Reviewed Original Research
2020
Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction
Vitek W, Sun F, Hoeger KM, Santoro N, Diamond MP, Zhang H, Legro RS, Network E, Coutifaris C, Christman G, Robinson R, Brzyski R, Schlaff W, Casson P, Trussell J, Eisenberg E, Lamar C, DePaolo L. Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction. Fertility And Sterility 2020, 114: 1032-1039. PMID: 33036790, PMCID: PMC7953832, DOI: 10.1016/j.fertnstert.2020.06.002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeShort-term weight changeUnexplained infertilityLive birth rateOvulation inductionOvary syndromeWeight changeWeight gainCycles of clomipheneBody mass indexMean weight changeBirth rateRandomized trialsMass indexRegular intercourseIntrauterine inseminationTreatment allocationLive birthsMAIN OUTCOMESecondary analysisWomenWeight assessmentBirthSyndromeInfertility
2019
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis
Wang R, Li W, Bordewijk E, Legro R, Zhang H, Wu X, Gao J, Morin-Papunen L, Homburg R, König T, Moll E, Kar S, Huang W, Johnson N, Amer S, Vegetti W, Palomba S, Falbo A, Özmen Ü, Nazik H, Williams C, Federica G, Lord J, Sahin Y, Bhattacharya S, Norman R, van Wely M, Mol B, Network+ R, Collaboration T. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update 2019, 25: 717-732. PMID: 31647106, DOI: 10.1093/humupd/dmz029.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical pregnancy rateClomiphene citrateLive birth rateOvulation inductionTime-to-pregnancyAnovulatory infertilityFrequent cause of anovulatory infertilityPregnancy rateCause of anovulatory infertilityBirth rateMetformin to CCOvulation induction agentsIncreased clinical pregnancyLive birthsPrimary randomised controlled trialsClinical pregnancyRandomised controlled trialsInfertilityIndividual participant dataIPD meta-analysesWomenPositive interactionsLetrozoleAccurate assessment of outcomesAssociation between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population
Trussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Heisenleder D, Smith J, Steiner A, Wild R, Casson P, Coutifaris C, Alvero RR, Robinson RB, Christman G, Patrizio P, Zhang H, Lindgren MC, Network R. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility And Sterility 2019, 111: 1129-1134. PMID: 30982604, PMCID: PMC6557574, DOI: 10.1016/j.fertnstert.2019.01.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersDown-RegulationFemaleFertilityHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMaleMulticenter Studies as TopicPregnancyPregnancy RateRandomized Controlled Trials as TopicRisk FactorsSperm CountSperm MotilitySpermatogenesisTestosteroneTreatment OutcomeConceptsUnexplained infertilityLow TTMale partnersLive birthsSemen parametersSecondary analysisMultiple Intrauterine GestationsLive birth rateBody mass indexMulticenter clinical trialAbnormal sperm morphologyOvarian stimulationIntrauterine gestationPregnancy outcomesMass indexInfertility clinicClinical trialsMAIN OUTCOMETotal motile spermSemen analysisAbnormal spermatogenesisInfertilityLogistic regressionSperm concentrationSemen volume
2018
Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility
Vitek W, Sun F, Hoeger K, Santoro N, Diamond M, Zhang H, Legro R. Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility. Fertility And Sterility 2018, 110: e68. DOI: 10.1016/j.fertnstert.2018.07.207.Peer-Reviewed Original ResearchLetter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”
Diamond MP, Huang H, Gracia C, Santoro N, Zhang H. Letter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 3110-3111. PMID: 29889234, PMCID: PMC6692707, DOI: 10.1210/jc.2018-00704.Peer-Reviewed Original ResearchMP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITY
Coward R, Stetter C, Kunselman A, Trussell J, Lindgren M, Diamond M, Hansen K, Krawetz S, Legro R, Patrizio P, Smith J, Steiner A, Wild R, Eisenberg E, Zhang H, Santoro N. MP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITY. Journal Of Urology 2018, 199: e249. DOI: 10.1016/j.juro.2018.02.663.Peer-Reviewed Original ResearchTransfer of Fresh Versus Frozen Embryos in Ovulatory Women
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro R, Chen Z. Transfer of Fresh Versus Frozen Embryos in Ovulatory Women. Obstetrical & Gynecological Survey 2018, 73: 213-214. DOI: 10.1097/ogx.0000000000000546.Peer-Reviewed Original Research
2016
Acupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trial
Wu X, Stener-Victorin E, Liu J, Wu T, Ng E, Legro R, Zhang H. Acupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trial. Fertility And Sterility 2016, 106: e375. DOI: 10.1016/j.fertnstert.2016.08.002.Peer-Reviewed Original Research
2015
Male obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
Polotsky A, Allshouse A, Krawetz S, Santoro N, Eisenberg E, Zhang H, Diamond M. Male obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Fertility And Sterility 2015, 104: e78. DOI: 10.1016/j.fertnstert.2015.07.238.Peer-Reviewed Original Research
2014
Letrozole or Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro RS, Zhang H. Letrozole or Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 1462-1464. PMID: 25295506, DOI: 10.1056/nejmc1409550.Peer-Reviewed Original Research
2012
Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome
Roth LW, Huang H, Legro RS, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Schlaff WD. Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 1151-1156. PMID: 22617579, PMCID: PMC3360417, DOI: 10.1097/aog.0b013e31825618fb.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFerriman-Gallwey scoreClomiphene citrateOvary syndromePolycystic Ovary Syndrome IDouble-blind trialDuration of treatmentAbsence of ovulationHirsutism scoreOvulation inductionHirsute womenHirsutismSecondary analysisMetforminWomenGroup assignmentSignificant decreaseSignificant differencesTreatmentSyndromeInfertilityGreater improvementScoresPregnancyGroup
2011
Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies
Schlaff WD, Zhang H, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Barnhart KT, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Santoro N, Eisenberg E, Huang H, Legro RS, Network R. Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies. Fertility And Sterility 2011, 96: 15-18. PMID: 21645894, PMCID: PMC3151556, DOI: 10.1016/j.fertnstert.2011.05.069.Peer-Reviewed Original ResearchConceptsPolycystic Ovary Syndrome IReproductive Medicine NetworkMulticenter clinical trialMulticenter trialClinical trialsSubstantial burdenInstitutional reviewClinical investigatorsMedicine NetworkSignificant increaseBurdenTrialsInstitutional review board requirementsObjective dataIRB submissionPregnancyInfertilityHuman research participantsYearsSignificant variability