2024
Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDisease
2020
Super‐variants identification for brain connectivity
Li T, Hu J, Wang S, Zhang H. Super‐variants identification for brain connectivity. Human Brain Mapping 2020, 42: 1304-1312. PMID: 33236465, PMCID: PMC7927294, DOI: 10.1002/hbm.25294.Peer-Reviewed Original ResearchConceptsCombination of allelesSingle nucleotide polymorphismsNovel lociBrain connectivityUK Biobank databaseChromosome 1Multiple lociGenetic effectsGenetic variantsNucleotide polymorphismsAssociation detectionLociGenetic associationGenesNeurodegenerative disordersBiobank databaseBrain issuesGenetic biomarkersBrain functionBrain structuresGenomeRSPO2Discovery phaseAssociationTMEM74