2023
Five Critical Gene-Based Biomarkers With Optimal Performance for Hepatocellular Carcinoma
Liu Y, Zhang H, Xu Y, Liu Y, Al-Adra D, Yeh M, Zhang Z. Five Critical Gene-Based Biomarkers With Optimal Performance for Hepatocellular Carcinoma. Cancer Informatics 2023, 22: 11769351231190477. PMID: 37577174, PMCID: PMC10413891, DOI: 10.1177/11769351231190477.Peer-Reviewed Original ResearchModel gene-gene interactionsCorrecting batch effectsGene-gene interactionsPublished transcriptomic studiesAnalysis of human cancersGene-based biomarkersWhole-transcriptome datasetsGenomic levelTranscriptome dataTranscriptomic studiesBatch effectsEffective therapeutic targetDEGsHuman cancersDisease etiologyMolecular backgroundCaucasian cohortTherapeutic targetIdentified 5Signature patternsIdentification of biomarkersConceptual advancesMiniaturized setting
2014
TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction
Song C, Zhang H. TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction. Genetic Epidemiology 2014, 38: 552-559. PMID: 25041903, PMCID: PMC4154634, DOI: 10.1002/gepi.21843.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSequence kernel association testRare variant dataTree-based analysisRare variantsNext-generation sequencing technologiesVariant dataGeneration sequencing technologyKernel association testGene-gene interactionsSequencing technologiesMultiple genesAssociation studiesDisease modelsRisk genesCTNNA2Genetic variantsSAGE dataComplex disease modelsGenesStudy of AddictionComplex diseasesCommon variantsSpecific variantsRisk of alcoholism
2009
Detecting Genes and Gene–Gene Interactions for Age-Related Macular Degeneration with a Forest-based Approach
Wang M, Zhang M, Chen X, Zhang H. Detecting Genes and Gene–Gene Interactions for Age-Related Macular Degeneration with a Forest-based Approach. Statistics In Biopharmaceutical Research 2009, 1: 424-430. PMID: 20161521, PMCID: PMC2799940, DOI: 10.1198/sbr.2009.0046.Peer-Reviewed Original Research