A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse