2024
Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location
WALTER J, BARNHART K, KOELPER N, SANTORO N, ZHANG H, THOMAS T, HUANG H, HARVIE H, Network E. Cost-effectiveness analysis of expectant vs active management for treatment of persistent pregnancies of unknown location. American Journal Of Obstetrics And Gynecology 2024, 231: 328.e1-328.e11. PMID: 38552817, DOI: 10.1016/j.ajog.2024.03.035.Peer-Reviewed Original ResearchQuality-adjusted life yearsTwo-dose methotrexateUterine evacuationExpectant managementIncremental cost-effectiveness ratioPersistent pregnancyCost-effectiveness ratioSurgical managementCost-effectiveness acceptability curvesPersistent pregnancy of unknown locationLife yearsLower-risk patient populationsSerum human chorionic gonadotropinPregnancies of unknown locationLaparoscopic surgical managementRate of salpingectomyManagement of pregnancyMean quality-adjusted life yearsMulticenter randomized trialRisk patient populationLower mean costsCosts of surgical interventionsHuman chorionic gonadotropinLower quality-adjusted life yearsAcceptability curves
2018
Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial
Barnhart KT, Sammel MD, Stephenson M, Robins J, Hansen KR, Youssef WA, Santoro N, Eisenberg E, Zhang H, Network F. Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial. Contemporary Clinical Trials 2018, 73: 145-151. PMID: 30243810, PMCID: PMC6231403, DOI: 10.1016/j.cct.2018.09.009.Peer-Reviewed Original ResearchConceptsOutcome measuresHuman chorionic gonadotropin concentrationRuptured ectopic pregnancyPositive pregnancy testSecondary outcome measuresExtra-uterine pregnancyInitial management strategyPrimary outcome measureChorionic gonadotropin concentrationsPatient satisfaction outcomesInitial management planAcademic medical centerEvidence-based managementAdditional ultrasonographyPersistent PULEctopic pregnancyExpectant managementAdverse eventsClinical resolutionEmpiric useGonadotropin concentrationsTransvaginal ultrasonographyTreatment complicationsTreatment armsUterine evacuation