2020
Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial
Hansen KR, Peck JD, Coward RM, Wild RA, Trussell JC, Krawetz SA, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H. Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial. Human Reproduction 2020, 35: 1296-1305. PMID: 32432326, PMCID: PMC7316499, DOI: 10.1093/humrep/deaa027.Peer-Reviewed Original ResearchConceptsTotal motile sperm countLive birth rateHigher total motile sperm countUnexplained infertilityMulticentre clinical trialMotile sperm countClinical trialsLive birthsOvarian stimulationHCG injectionBirth ratePatient discomfortSperm countTreatment cyclesSecondary analysisEunice Kennedy Shriver National InstituteSTUDY FUNDING/COMPETINGLive birth successMultiple Intrauterine GestationsDuration of infertilityIUI treatment cyclesLive birth outcomesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of age
2018
Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome
Christianson MS, Legro RS, Jin S, Eisenberg E, Diamond MP, Hansen KR, Vitek W, Styer AK, Casson P, Coutifaris C, Christman GM, Alvero R, Puscheck EE, Christy AY, Sun F, Zhang H, Polotsky AJ, Santoro N. Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome. Journal Of Assisted Reproduction And Genetics 2018, 35: 2173-2180. PMID: 30194618, PMCID: PMC6289919, DOI: 10.1007/s10815-018-1306-2.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeSaline infusion sonohysterographyTubal patencyClinical pregnancyOvary syndromePolycystic Ovary Syndrome IITubal patency assessmentClinical pregnancy rateDuration of infertilityAcceptable imaging modalityIntrauterine pregnancyClomiphene citrateEctopic pregnancyInfertile womenResultsAmong womenMultivariable analysisPatency assessmentTreatment armsTreatment trialsPregnancy rateMethodsSecondary analysisHysterosalpingogramLarge cohortTubes patentPatency
2017
Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome
Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro RS, Zhang H, Chen ZJ. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 3822-3829. PMID: 28938429, DOI: 10.1210/jc.2017-01294.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testPolycystic ovary syndromePregnancy outcomesI-IFGOvary syndromeGlucose toleranceHigh riskIntrinsic insulin resistanceAdverse pregnancy outcomesTotal testosterone levelsDuration of infertilityImpaired glucose tolerancePregnancy loss rateBody mass indexFrozen embryo transferGlucose tolerance testMain outcome measuresGestational diabetesObstetric complicationsSingleton newbornsSingleton pregnanciesGestational ageMass indexTwin pregnanciesInsulin levels
2016
Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine insemination
Hansen KR, He AL, Styer AK, Wild RA, Butts S, Engmann L, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Huang H, Santoro N, Eisenberg E, Zhang H, Network E. Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine insemination. Fertility And Sterility 2016, 105: 1575-1583.e2. PMID: 26949110, PMCID: PMC4893990, DOI: 10.1016/j.fertnstert.2016.02.020.Peer-Reviewed Original ResearchConceptsDuration of infertilityUnexplained infertilityPregnancy outcomesClinical trialsClinical pregnancyBaseline characteristicsLive birthsMultivariable logistic regression analysisMultiple Intrauterine GestationsMultiple pregnancy ratePredictors of pregnancyPrior pregnancy lossLive birth rateMulticenter clinical trialSignificant predictorsLogistic regression analysisClomiphene citrateOvarian stimulationAntimüllerian hormoneIntrauterine gestationSerum levelsWaist circumferencePregnancy lossObstetrical carePregnancy rate