Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence
Zhang H, Liu D, Zhao J, Bi X. Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence. The Annals Of Applied Statistics 2018, 12: 2359-2378. PMID: 30666272, PMCID: PMC6338437, DOI: 10.1214/18-aoas1156.Peer-Reviewed Original ResearchFull likelihoodComplicated likelihood functionsParametric frameworkParametric modeling frameworkHigh computational complexityExtensive simulation studyModel fitting algorithmStatistical inferenceRank-based methodLikelihood functionComputational burdenType I error ratesComputational complexityFitting algorithmSimulation studyNovel multivariate modelModeling frameworkEffect size estimationLatent variablesHybrid modelInferenceSize estimationModelFrameworkTheory