2007
A genomic imprinting test for ordinal traits in pedigree data
Feng R, Zhang H. A genomic imprinting test for ordinal traits in pedigree data. Genetic Epidemiology 2007, 32: 132-142. PMID: 17922481, DOI: 10.1002/gepi.20270.Peer-Reviewed Original ResearchConceptsComplex genetic basisOrdinal traitsIdentical nucleotide sequencesGenomic imprintingNumerous common diseasesNovel lociNucleotide sequenceComplex inheritanceGenetic basisChromosome 3Non-genetic covariatesHuman disordersLinkage analysisHuman diseasesGenetics of AlcoholismChromosome 18Continuous traitsTraitsPedigree dataBinary traitsOrigin effectsImprinting testLociStrong signalImprinting
2003
A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse