2024
Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine
Hu J, Wang S, Zhang H. Variant Selection and Aggregation of Genetic Association Studies in Precision Medicine. ICSA Book Series In Statistics 2024, 423-451. DOI: 10.1007/978-3-031-50690-1_17.Peer-Reviewed Original ResearchAssociation studiesGenetic association studiesPrecision medicineTests of associationHeterogeneous drug responsesDisease risk predictionVariant identificationSignal variantsControl of type I errorDisease riskDrug responseGenomic profilingType I errorRisk predictionGenetic biomarkersVariantsPharmaceutical interventionsMarginal testsAssociation methodAssociationMedicineInterventionIdentificationReplicationDisease
2020
Super‐variants identification for brain connectivity
Li T, Hu J, Wang S, Zhang H. Super‐variants identification for brain connectivity. Human Brain Mapping 2020, 42: 1304-1312. PMID: 33236465, PMCID: PMC7927294, DOI: 10.1002/hbm.25294.Peer-Reviewed Original ResearchConceptsCombination of allelesSingle nucleotide polymorphismsNovel lociBrain connectivityUK Biobank databaseChromosome 1Multiple lociGenetic effectsGenetic variantsNucleotide polymorphismsAssociation detectionLociGenetic associationGenesNeurodegenerative disordersBiobank databaseBrain issuesGenetic biomarkersBrain functionBrain structuresGenomeRSPO2Discovery phaseAssociationTMEM74
2019
Common genetic variants have associations with human cortical brain regions and risk of schizophrenia
Bi X, Feng L, Wang S, Lin Z, Li T, Zhao B, Zhu H, Zhang H. Common genetic variants have associations with human cortical brain regions and risk of schizophrenia. Genetic Epidemiology 2019, 43: 548-558. PMID: 30941828, PMCID: PMC6559856, DOI: 10.1002/gepi.22203.Peer-Reviewed Original ResearchConceptsCortical regionsCortical brain regionsRisk of schizophreniaPrefrontal cortical regionsSymptom durationProdromal symptomsMental disordersSignificant associationBrain regionsCommon genetic variantsPhiladelphia Neurodevelopmental CohortPediatric imagingSchizophreniaNeurodevelopmental CohortCommon variantsHuman brainGenetic variantsHeritable mental disorderMagnetic resonanceAssociationWide association studyAssociation studiesGenetic effectsCohortSymptoms
2008
Joint Modeling of Time Series Measures and Recurrent Events and Analysis of the Effects of Air Quality on Respiratory Symptoms
Zhang H, Ye Y, Diggle P, Shi J. Joint Modeling of Time Series Measures and Recurrent Events and Analysis of the Effects of Air Quality on Respiratory Symptoms. Journal Of The American Statistical Association 2008, 103: 48-60. DOI: 10.1198/016214507000000185.Peer-Reviewed Original ResearchRespiratory symptomsRunny noseInfant symptomsCough incidenceCough symptomsMothers' symptomsInfant Health StudyRespiratory symptom dataRecurrent eventsMixed effects regression modelsRisk factorsHealth StudySignificant associationSymptom dataSymptomsInfantsSensitive childrenMothersSulfate levelsRegression modelsSignificant effectRiskNoseAssociationHigh levels
2004
Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.Peer-Reviewed Original Research