2003
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum
Martinez D, Slifstein M, Broft A, Mawlawi O, Hwang DR, Huang Y, Cooper T, Kegeles L, Zarahn E, Abi-Dargham A, Haber SN, Laruelle M. Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum. Cerebrovascular And Brain Metabolism Reviews 2003, 23: 285-300. PMID: 12621304, DOI: 10.1097/01.wcb.0000048520.34839.1a.Peer-Reviewed Original ResearchConceptsD2 receptor availabilityPositron emission tomographyReceptor availabilityHuman striatumFunctional subdivisionsDopamine releaseAssociative regionsSensorimotor regionsEmission tomographyAmphetamine-induced dopamine releaseIntegration of limbicMesolimbic dopamine transmissionDopamine D2 receptorsVoxel-based analysisPriming bolusSensorimotor subdivisionsAmphetamine administrationMotor functionStriatal functionD2 receptorsIntravenous administrationStriatal subregionsVentral midbrainHealthy volunteersDopamine transmission
2001
Imaging Human Mesolimbic Dopamine Transmission With Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum
Mawlawi O, Martinez D, Slifstein M, Broft A, Chatterjee R, Hwang D, Huang Y, Simpson N, Ngo K, Van Heertum R, Laruelle M. Imaging Human Mesolimbic Dopamine Transmission With Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 1034-1057. PMID: 11524609, DOI: 10.1097/00004647-200109000-00002.Peer-Reviewed Original ResearchConceptsPositron emission tomographyVentral striatumDopamine transmissionReceptor measurementsEmission tomographyMesolimbic dopamine transmissionHigh-resolution magnetic resonanceNonspecific partition coefficientDrugs of abuseDorsal putamenPostmortem studiesVentral putamenDorsal caudateVentral caudateNucleus accumbensConstant infusion methodReceptor availabilityPsychotic statesStriatumReceptorsPutamenCaudateSpecific bindingInfusion methodTomographyVulnerability of positron emission tomography radiotracers to endogenous competition. New insights.
Laruelle M, Huang Y. Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights. Quarterly Journal Of Nuclear Medicine And Molecular Imaging 2001, 45: 124-38. PMID: 11476162.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzamidesBrainDopamineHumansPyrrolidinesRacloprideReceptors, DopamineTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsTransmitter levelsSynaptic dopamine concentrationsPositron emission tomographyDA transmissionD2 receptorsNeurotransmitter systemsPharmacological challengeDevelopment of PETSynaptic transmitter levelsEmission tomographyDopamine concentrationsAcute fluctuationsReceptor traffickingHuman brainRadioligandImaging techniquesVivoEndogenous competitionPETBinding competitionNeurotransmittersBrainReceptorsSynthesis of potent and selective dopamine D4 antagonists as candidate radioligands
Huang Y, Kegeles L, Bae S, Hwang D, Roth B, Savage J, Laruelle M. Synthesis of potent and selective dopamine D4 antagonists as candidate radioligands. Bioorganic & Medicinal Chemistry Letters 2001, 11: 1375-1377. PMID: 11378358, DOI: 10.1016/s0960-894x(01)00241-4.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesDopamine AntagonistsDopamine D2 Receptor AntagonistsPyridinesPyrrolesRadioligand AssayReceptors, Dopamine D2Receptors, Dopamine D4Receptors, SerotoninTomography, Emission-ComputedAnalyses of [18F]altanserin bolus injection PET data. II: Consideration of radiolabeled metabolites in humans
Price J, Lopresti B, Meltzer C, Smith G, Mason N, Huang Y, Holt D, Gunn R, Mathis C. Analyses of [18F]altanserin bolus injection PET data. II: Consideration of radiolabeled metabolites in humans. Synapse 2001, 41: 11-21. PMID: 11354009, DOI: 10.1002/syn.1055.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood-Brain BarrierFemaleFluorine RadioisotopesHumansKetanserinMaleMiddle AgedModels, BiologicalReceptor, Serotonin, 5-HT2AReceptors, SerotoninTomography, Emission-ComputedConceptsBlood-brain barrierPositron emission tomographyPrevious animal studiesAntagonist radiotracersPET dataBolus injectionAnimal studiesReference tissue methodEmission tomographyPET studiesArterial inputTissue measuresConstant radioactivityLogan analysisFurther studiesHigh-performance liquid chromatography analysisRadiometabolitesTissue methodLiquid chromatography analysisMetabolitesInjectionBolusAnalyses of [18F]altanserin bolus injection PET data. I: Consideration of radiolabeled metabolites in baboons
Price J, Lopresti B, Mason N, Holt D, Huang Y, Mathis C. Analyses of [18F]altanserin bolus injection PET data. I: Consideration of radiolabeled metabolites in baboons. Synapse 2001, 41: 1-10. PMID: 11354008, DOI: 10.1002/syn.1054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBrainFluorine RadioisotopesKetanserinModels, BiologicalPapioTissue DistributionTomography, Emission-ComputedConceptsBolus injectionMajor radiometabolitePositron emission tomographySerotonin 2A receptor bindingBlood-brain barrier passageReceptor-rich regionsKetanserin administrationNonspecific radioactivityReceptor blockadeInput function methodEmission tomographyPET studiesPET dataReceptor bindingRadiometabolitesVivo kineticsInjectionBBBTissue componentsHuman brainBaboonsMetabolitesRadioactivityBlockadeAntagonistDifferential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans
Martinez D, Hwang D, Mawlawi O, Slifstein M, Kent J, Simpson N, Parsey R, Hashimoto T, Huang Y, Shinn A, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann J, Laruelle M. Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans. Neuropsychopharmacology 2001, 24: 209-229. PMID: 11166513, DOI: 10.1016/s0893-133x(00)00187-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsBrainHumansKineticsMagnetic Resonance ImagingMaleMood DisordersPindololPiperazinesPyridinesRaphe NucleiReceptors, NeurotransmitterReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsSynaptic TransmissionTomography, Emission-ComputedConceptsDorsal raphe nucleusPositron emission tomographyClinical studiesSelective serotonin reuptake inhibitor (SSRI) therapyPlacebo-controlled clinical studySerotonin reuptake inhibitor therapyEmission tomographyAbility of pindololPindolol augmentationAntidepressant therapyAntidepressant treatmentClinical responseInhibitor therapyRaphe nucleusScan 3Scan 4Therapeutic effectHealthy volunteersScan 2Vivo selectivityPindololAutoreceptorsSSRIsTherapyInconsistent results
2000
Positron emission tomography study of pindolol occupancy of 5-HT1A receptors in humans: preliminary analyses
Martinez D, Mawlawi O, Hwang D, Kent J, Simpson N, Parsey R, Hashimoto T, Slifstein M, Huang Y, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann J, Laruelle M. Positron emission tomography study of pindolol occupancy of 5-HT1A receptors in humans: preliminary analyses. Nuclear Medicine And Biology 2000, 27: 523-527. PMID: 10962261, DOI: 10.1016/s0969-8051(00)00122-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain ChemistryHumansMaleMiddle AgedPindololRaphe NucleiReceptors, SerotoninReceptors, Serotonin, 5-HT1Serotonin AntagonistsTomography, Emission-ComputedConceptsDorsal raphe nucleusClinical studiesPositron emission tomographyPlacebo-controlled clinical studySerotonin reuptake inhibitor therapyCortical regionsAbility of pindololPositron emission tomography studyInitiation of treatmentEmission tomography studiesDRN 5Pindolol augmentationPindolol doseAntidepressant therapyAntidepressant responseInhibitor therapySerotonin transmissionRaphe nucleusScan 3SSRI effectsPostsynaptic receptorsScan 4Clinical trialsOral administrationPreclinical studies
1999
Pet imaging of serotonin 1A receptor binding in depression
Drevets W, Frank E, Price J, Kupfer D, Holt D, Greer P, Huang Y, Gautier C, Mathis C. Pet imaging of serotonin 1A receptor binding in depression. Biological Psychiatry 1999, 46: 1375-1387. PMID: 10578452, DOI: 10.1016/s0006-3223(99)00189-4.Peer-Reviewed Original ResearchConceptsFamilial mood disordersReceptor BPPostmortem studiesMood disordersMesiotemporal cortexMidbrain rapheSerotonin 1A receptor systemBrain regionsPET imagingPrevious postmortem studiesSerotonin 1A receptorMultiple brain regionsHistopathological changesHealthy controlsBP valuesMajor depressionDepressed phasePostcentral gyrusClinical conditionsOccipital cortexBipolar relativesBipolar depressivesReceptor radioligandDepressed subjectsNormal baseline
1998
Test–retest variability of serotonin 5‐HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain
Smith G, Price J, Lopresti B, Huang Y, Simpson N, Holt D, Mason N, Meltzer C, Sweet R, Nichols T, Sashin D, Mathis C. Test–retest variability of serotonin 5‐HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain. Synapse 1998, 30: 380-392. PMID: 9826230, DOI: 10.1002/(sici)1098-2396(199812)30:4<380::aid-syn5>3.0.co;2-u.Peer-Reviewed Original Research