2024
Novel 18F‑Labeled Benzimidazolone-Based Radioligands as Highly Selective Sigma‑2 Receptor Probes for Tumor Imaging
Wang J, Wang T, Mou T, Yang T, Gao X, An X, Hu B, Zhang J, Zhang X, Deuther-Conrad W, Huang Y, Jia H. Novel 18F‑Labeled Benzimidazolone-Based Radioligands as Highly Selective Sigma‑2 Receptor Probes for Tumor Imaging. Journal Of Medicinal Chemistry 2024, 67: 17392-17406. DOI: 10.1021/acs.jmedchem.4c01315.Peer-Reviewed Original ResearchSmall-animal PET/CTS2 receptorsAnimal PET/CTHigh subtype selectivityGlioma modelCo-administrationPET/CTLung cancerGlioma xenograftsBlocking studiesU87MG xenograftsA549 lung cancerCompound 4U87MG glioma xenograftsTumorTumor imagingReceptorsSubtype selectivityXenograftsRadiochemical yieldRadioligandSigma-2Active uptakeMolar activityU87MG
2023
Development of a Highly Specific 18F‑Labeled Radioligand for Imaging of the Sigma‑2 Receptor in Brain Tumors
Wang T, Wang J, Chen L, Zhang X, Mou T, An X, Zhang J, Zhang X, Deuther-Conrad W, Huang Y, Jia H. Development of a Highly Specific 18F‑Labeled Radioligand for Imaging of the Sigma‑2 Receptor in Brain Tumors. Journal Of Medicinal Chemistry 2023, 66: 12840-12857. PMID: 37704582, DOI: 10.1021/acs.jmedchem.3c00735.Peer-Reviewed Original ResearchMicro-PET/CT imagingSigma-2 receptorsTumor uptakeCT imagingClear tumor visualizationGlioma xenograft modelU87MG glioma xenograftsHigh subtype selectivityHigh tumor uptakeHigh specific bindingGlioma xenograftsBrain tumorsXenograft modelTumor visualizationSubtype selectivityReceptorsTumorsRadioligandSpecific bindingGBq/ImagingRadiochemical purityNanomolar affinity