2019
Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.
Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.Peer-Reviewed Original ResearchConceptsTherapeutic targetAberrant wound healing processAppropriate physiologic responseMorbid disease processSurvival of myofibroblastsWound healingFibrotic signaling pathwaysTranscription factor/serum response factor (MRTF/SRF) pathwayFuture therapeutic targetsSmooth muscle actinFuture translational researchCurrent literatureFibrotic signalingTherapeutic optionsFibrotic lesionsTissue injuryWound healing processDisease processPhysiologic responsesSerum response factor pathwayMuscle actinFactor pathwayExcessive responseFibrosisTranslational research
2017
Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene 2017, 36: 6668-6679. PMID: 28783178, PMCID: PMC5709202, DOI: 10.1038/onc.2017.278.Peer-Reviewed Original ResearchConceptsAdipose tissueFibroblast growth factor-2 levelsGrowth factor-2 levelsFGFR-1Cancer prevention strategiesEpithelial cellsExcess adipose tissueTumor formationFactor 2 levelsVisceral adipose tissueNovel ex vivo systemSkin tumor formationObese human donorsNon-tumorigenic epithelial cellsSoft agarEx vivo systemGrowth factor receptorAdjuvant therapyEpithelial cell growthVisceral adiposityLevels of FGF2Obese individualsEpidemiological evidenceFibroblast growth factor receptorCancer risk
2014
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
Desai VD, Hsia HC, Schwarzbauer JE. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLOS ONE 2014, 9: e86865. PMID: 24466271, PMCID: PMC3900664, DOI: 10.1371/journal.pone.0086865.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueBlotting, WesternCell DifferentiationCell MovementCells, CulturedExtracellular Matrix ProteinsFibroblast Growth Factor 2HumansMesenchymal Stem CellsMyofibroblastsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsExtracellular matrixERK/MAP kinaseMyofibroblastic phenotypeStem cellsRegulation of tenascinProtein type IActivation of Smad2Abundant extracellular matrixFocal adhesionsGrowth factorKinase downstreamHuman adipose-derived mesenchymal stem cellsCytoskeletal proteinsMAP kinaseStress fibersECM proteinsCell differentiationADSC differentiationDifferentiation processFibroblast-like cellsMyofibroblast differentiationNovel therapeutic strategiesRegenerative medicine
2006
Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair
Midwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE. Modulation of Cell–Fibronectin Matrix Interactions during Tissue Repair. Journal Of Investigative Dermatology Symposium Proceedings 2006, 11: 73-78. PMID: 17069013, DOI: 10.1038/sj.jidsymp.5650005.Peer-Reviewed Original ResearchConceptsFocal adhesion kinaseExtracellular matrixAlpha 4 beta 1Fibronectin matrixActin stress fibersECM protein tenascinAlpha v beta 3Cell surface receptorsFibrin-fibronectin matrixOrganization of fibronectinAlpha 5 beta 1 integrin receptorBeta 3 integrinActin cytoskeletonBeta 1 integrin receptorsEnvironmental signalsMotile phenotypeTransmembrane proteoglycansAdhesion kinaseRho GTPaseRho signalingWound provisional matrixBeta 1Stress fibersIntegrin functionMultiple intracellular
2004
Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4
Midwood KS, Valenick LV, Hsia HC, Schwarzbauer JE. Coregulation of Fibronectin Signaling and Matrix Contraction by Tenascin-C and Syndecan-4. Molecular Biology Of The Cell 2004, 15: 5670-5677. PMID: 15483051, PMCID: PMC532045, DOI: 10.1091/mbc.e04-08-0759.Peer-Reviewed Original ResearchConceptsSyndecan-4 functionsSyndecan-4Actin stress fiber formationFocal adhesion kinaseMatrix contractionStress fiber formationExtracellular matrix proteinsEfficient tissue repairEffects of tenascinProvisional matrixTissue repairHeparan sulfate proteoglycanAdhesion kinaseCell spreadingSignaling pathwaysMatrix proteinsFibronectin signalingThree-dimensional fibrinExtracellular matrixFiber formationSulfate proteoglycanCell interactionsFibroblast morphologyTenascinFibroblast response